U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    bcl9.L BCL9 transcription coactivator L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 431941, updated on 4-Nov-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    bcl9.L
    Official Full Name
    BCL9 transcription coactivator L homeolog
    Primary source
    Xenbase:XB-GENE-865416
    Locus tag
    XELAEV_18011365mg
    See related
    EnsemblRapid:ENSXLAG00005034485 AllianceGenome:Xenbase:XB-GENE-865416
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    lgs; bcl9; xbcl9; legless
    Summary
    Predicted to enable beta-catenin binding activity and transcription coactivator activity. Predicted to act upstream of or within canonical Wnt signaling pathway and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of beta-catenin-TCF complex. Is expressed in ectoderm; nervous system; pharyngeal arch; and visual system. Orthologous to human BCL9 (BCL9 transcription coactivator). [provided by Alliance of Genome Resources, Nov 2024]
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See bcl9.L in Genome Data Viewer
    Location:
    chromosome: 2L
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (7982773..8148614, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (7776832..7807029, complement)

    Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene gap junction protein alpha 8 L homeolog Neighboring gene gap junction protein alpha 5 L homeolog Neighboring gene transmembrane serine protease 3 L homeolog Neighboring gene trefoil factor 3, gene 1 L homeolog Neighboring gene trefoil factor 3, gene 2 L homeolog

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus. Kennedy MW, et al. Dev Dyn, 2010 Jan. PMID 19877304
    2. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both XBcl9 and XPygo2 are required to induce supernumerary axis and dorsal gene activation in Xenopus embryos.
      Title: A co-dependent requirement of xBcl9 and Pygopus for embryonic body axis development in Xenopus.
    Submit: New GeneRIF Correction

    General gene information

    Go to the top of the page Help

    Homology

    Clone Names

    • MGC83888

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transcription coactivator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within canonical Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of beta-catenin-TCF complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    BCL9 transcription coactivator L homeolog
    Names
    B cell CLL/lymphoma 9 L homeolog
    B-cell lymphoma 9
    B-cell lymphoma 9 protein

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001091421.1 → NP_001084890.1  BCL9 transcription coactivator L homeolog

      See identical proteins and their annotated locations for NP_001084890.1

      Status: PROVISIONAL

      Source sequence(s)
      BC070813
      UniProtKB/TrEMBL
      Q6NRE2
      Conserved Domains (2) summary
      TIGR01628
      Location:476 → 583
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam11502
      Location:344 → 382
      BCL9; B-cell lymphoma 9 protein

    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      7982773..8148614 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041580939.1 → XP_041436873.1  BCL9 transcription coactivator L homeolog isoform X1

      UniProtKB/TrEMBL
      D0EUZ9
      Related
      ENSXLAP00005103334.1, ENSXLAT00005105339.1
      Conserved Domains (4) summary
      TIGR01628
      Location:541 → 648
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      PHA03247
      Location:935 → 1260
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:642 → 1043
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11502
      Location:409 → 447
      BCL9; B-cell lymphoma 9 protein

    2. XM_041580940.1 → XP_041436874.1  BCL9 transcription coactivator L homeolog isoform X2

      UniProtKB/TrEMBL
      A0A8J1M5B2
      Conserved Domains (4) summary
      TIGR01628
      Location:540 → 647
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      PHA03247
      Location:934 → 1259
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:641 → 1042
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11502
      Location:408 → 446
      BCL9; B-cell lymphoma 9 protein

    3. XM_041580941.1 → XP_041436875.1  BCL9 transcription coactivator L homeolog isoform X3

      UniProtKB/TrEMBL
      A0A1L8HC43, A0A974DM46
      Related
      ENSXLAP00005103228.1, ENSXLAT00005105233.1
      Conserved Domains (4) summary
      TIGR01628
      Location:541 → 648
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      pfam05109
      Location:921 → 1075
      Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
      pfam09606
      Location:945 → 1336
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11502
      Location:409 → 447
      BCL9; B-cell lymphoma 9 protein

    4. XM_041580937.1 → XP_041436871.1  BCL9 transcription coactivator L homeolog isoform X1

      UniProtKB/TrEMBL
      D0EUZ9
      Related
      ENSXLAP00005103165.1, ENSXLAT00005105170.1
      Conserved Domains (4) summary
      TIGR01628
      Location:541 → 648
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      PHA03247
      Location:935 → 1260
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:642 → 1043
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11502
      Location:409 → 447
      BCL9; B-cell lymphoma 9 protein

    5. XM_041580938.1 → XP_041436872.1  BCL9 transcription coactivator L homeolog isoform X1

      UniProtKB/TrEMBL
      D0EUZ9
      Related
      ENSXLAP00005103254.1, ENSXLAT00005105259.1
      Conserved Domains (4) summary
      TIGR01628
      Location:541 → 648
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      PHA03247
      Location:935 → 1260
      PHA03247; large tegument protein UL36; Provisional
      pfam09606
      Location:642 → 1043
      Med15; ARC105 or Med15 subunit of Mediator complex non-fungal
      pfam11502
      Location:409 → 447
      BCL9; B-cell lymphoma 9 protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.