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    M2 membrane protein M2 [ Influenza A virus (A/Korea/426/1968(H2N2)) ]

    Gene ID: 3655107, updated on 18-Aug-2023

    Summary

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    Gene symbol
    M2
    Gene description
    membrane protein M2
    Locus tag
    FLUAVH2N2_s7p1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Influenza A virus (A/Korea/426/1968(H2N2)) (strain: A/Korea/426/1968, serotype: H2N2)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
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    Genomic context

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    Location:
    segment: 7
    Sequence:
    NC_007377.1 (26..1007)

    NC_007377.1Genomic Context describing neighboring genes Neighboring gene membrane protein M1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_007377.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species. Lazrak A, et al. FASEB J, 2009 Nov. PMID 19596899, Free PMC Article
    2. pH-induced conformational change of the influenza M2 protein C-terminal domain. Nguyen PA, et al. Biochemistry, 2008 Sep 23. PMID 18754675, Free PMC Article
    3. Proton transport through influenza A virus M2 protein reconstituted in vesicles. Moffat JC, et al. Biophys J, 2008 Jan 15. PMID 17827230, Free PMC Article
    4. How pH opens a H+ channel: the gating mechanism of influenza A M2. Kass I, et al. Structure, 2005 Dec. PMID 16338407
    5. Evolutionary analysis of the influenza A virus M gene with comparison of the M1 and M2 proteins. Ito T, et al. J Virol, 1991 Oct. PMID 1895397, Free PMC Article

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. M2 protein increases steady-state concentrations of reactive oxygen intermediates that simulate PKC and decrease ENaCs by enhancing endocytosis and its subsequent destruction by the proteasome
      Title: Influenza virus M2 protein inhibits epithelial sodium channels by increasing reactive oxygen species.
    2. The carboxyl-terminal surface helix of M2 plays a more active role in the pH activation process: residue lysine-49 is shown to be critical to the function of the channel.
      Title: pH-induced conformational change of the influenza M2 protein C-terminal domain.
    3. M2 exhibits approximately 10(7) selectivity for hydrogen over potassium.
      Title: Proton transport through influenza A virus M2 protein reconstituted in vesicles.
    4. While all channel protonation states of M2 protein are surprisingly stable, only systems with two or more charged histidines are appreciably conductive.
      Title: How pH opens a H+ channel: the gating mechanism of influenza A M2.
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    General gene information

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    Homology

    General protein information

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    Preferred Names
    membrane protein M2

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007377.1 Reference assembly

      Range
      26..1007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_308853.1 membrane protein M2 [Influenza A virus (A/Korea/426/1968(H2N2))]

      See identical proteins and their annotated locations for YP_308853.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P10920, Q67179
      UniProtKB/TrEMBL
      A4GC11, A4JZ51, A4Z3Z9, A5GXB8, B2VMP3, B2VMQ4, B6A718, C7S205, D6R8N1, E6XTS8, E6XUD9, K4P102, K4P177, K4P3A7, Q0A2X2, Q1K9K0, Q288V1, Q4ZH96, Q6XTX8, Q6XTY0, Q6XTY2, Q6XTY6, Q6XU10, Q6XU16
      Conserved Domains (1) summary
      pfam00599
      Location:1 → 97
      Flu_M2; Influenza Matrix protein (M2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q67179.1

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