U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from Protein

    • Showing Current items.

    NS1 nonstructural protein 1 [ Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) ]

    Gene ID: 8656648, updated on 18-Aug-2023

    Summary

    Go to the top of the page Help
    Gene symbol
    NS1
    Gene description
    nonstructural protein 1
    Locus tag
    FLUAVH5N1_s8gp2
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Influenza A virus (A/goose/Guangdong/1/1996(H5N1)) (strain: A/goose/Guangdong/1/1996, serotype: H5N1)
    Lineage
    Viruses; ssRNA viruses; ssRNA negative-strand viruses; Orthomyxoviridae; Influenzavirus A
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    segment: 8
    Sequence:
    NC_007364.1 (15..707)

    NC_007364.1Genomic Context describing neighboring genes Neighboring gene nonstructural protein 2

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_007364.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding. Wang X, et al. Vet Microbiol, 2020 Dec. PMID 33126184
    2. Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells. Li J, et al. Virology, 2018 Jun. PMID 29677653
    3. Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus. Ma Y, et al. BMC Microbiol, 2017 Sep 11. PMID 28893180, Free PMC Article
    4. Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1. Kato YS, et al. Protein Pept Lett, 2016. PMID 26845765
    5. Synergistic effect of the PDZ and p85β-binding domains of the NS1 protein on virulence of an avian H5N1 influenza A virus. Fan S, et al. J Virol, 2013 May. PMID 23408626, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
      Title: Natural Selection of H5N1 Avian Influenza A Viruses with Increased PA-X and NS1 Shutoff Activity.
    2. The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
      Title: The N-terminal residual arginine(19) of influenza A virus NS1 protein is required for its nuclear localization and RNA binding.
    3. Differential modulation of innate immune responses in human primary cells by influenza A viruses carrying human or avian NS1 protein has been reported.
      Title: Differential Modulation of Innate Immune Responses in Human Primary Cells by Influenza A Viruses Carrying Human or Avian Nonstructural Protein 1.
    4. study demonstrated that the amino acid at positions 55, 66, and 133 of NS1 play an important role in the ability of H5N1 influenza viruses to dampen the host IFN response
      Title: Three amino acid substitutions in the NS1 protein change the virus replication of H5N1 influenza virus in human cells.
    5. ANXA2 interacts with NS1 and ANXA2 expression increases highly pathogenic H5N1 avian influenza virus replication.
      Title: Annexin A2 (ANXA2) interacts with nonstructural protein 1 and promotes the replication of highly pathogenic H5N1 avian influenza virus.
    6. Studies showed that the replacement of the 42nd residue of NS1 has a direct impact on the binding to dsRNA, so that the 42nd residue should be responsible for the high pathogenicity of H5N1. The structural models also suggested that the replacement causes structural change within the RNA-binding domain , leading to the change in the dsRNA-binding affinity.
      Title: Mechanism of a Mutation in Non-Structural Protein 1 Inducing High Pathogenicity of Avian Influenza Virus H5N1.
    7. analysis yielded chicken gga-miR-1658* as the potential miRNA which is targeting the NS1 gene of H5N1 genome
      Title: In-silico search of virus-specific host microRNAs regulating avian influenza virus NS1 expression.
    8. D120 and R195 of H5N1 influenza virus NS1 were crucial for the binding to host NOLC1.
      Title: Identification of NS1 domains of avian H5N1 influenza virus which influence the interaction with the NOLC1 protein.
    9. This is the first report to elucidate the novel function of NS1--binding protein collaborating with viral protein NS1 in modulation of host cell physiology. In addition, an alternative role of adaptor protein CRKL in association with NS1 and NS1-BP during influenza A virus infection is demonstrated.
      Title: NS1-binding protein abrogates the elevation of cell viability by the influenza A virus NS1 protein in association with CRKL.
    10. H5N1 viral NS1 interacts with host NOLC1 protein.
      Title: Interaction of avian influenza virus NS1 protein and nucleolar and coiled-body phosphoprotein 1.
    Submit: New GeneRIF Correction See all GeneRIFs (18)

    General gene information

    Go to the top of the page Help

    Homology

    General protein information

    Go to the top of the page Help
    Preferred Names
    nonstructural protein 1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_007364.1 Reference assembly

      Range
      15..707
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. YP_308673.1 nonstructural protein 1 [Influenza A virus (A/goose/Guangdong/1/1996(H5N1))]

      See identical proteins and their annotated locations for YP_308673.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      Q9Q0L6
      UniProtKB/TrEMBL
      B1MPQ7, D1LMQ9, Q91R63, Q9EA66
      Conserved Domains (1) summary
      pfam00600
      Location:1 → 216
      Flu_NS1; Influenza non-structural protein (NS1)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Q0L6.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.