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    MET MET proto-oncogene, receptor tyrosine kinase [ Microcebus murinus (gray mouse lemur) ]

    Gene ID: 105869368, updated on 11-Apr-2024

    Summary

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    Gene symbol
    MET
    Gene description
    MET proto-oncogene, receptor tyrosine kinase
    See related
    Ensembl:ENSMICG00000000697
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Microcebus murinus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Strepsirrhini; Lemuriformes; Cheirogaleidae; Microcebus
    Orthologs
    human mouse all
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    Genomic context

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    See MET in Genome Data Viewer
    Location:
    chromosome: 11
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    101 current Mmur_3.0 (GCF_000165445.2) 11 NC_033670.1 (32572413..32678497, complement)
    100 previous assembly Mmur_2.0 (GCF_000165445.1) Unplaced Scaffold NW_012205218.1 (601087..707139)

    Chromosome 11 - NC_033670.1Genomic Context describing neighboring genes Neighboring gene suppression of tumorigenicity 7 Neighboring gene capping actin protein of muscle Z-line subunit alpha 2 Neighboring gene caveolin 1 Neighboring gene caveolin 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RefSeq

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables protein binding IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables semaphorin receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in negative regulation of cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in phagocytosis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of axonogenesis IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in positive regulation of kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in protein phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of GTPase activity IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in regulation of cell shape IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    involved_in semaphorin-plexin signaling pathway involved in axon guidance IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 
    part_of semaphorin receptor complex IEA
    Inferred from Electronic Annotation
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    hepatocyte growth factor receptor
    Names
    HGF receptor
    HGF/SF receptor
    Hepatocyte growth factor receptor
    Proto-oncogene c-Met
    SF receptor
    Scatter factor receptor
    Tyrosine-protein kinase Met

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Microcebus murinus Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Mmur_3.0 Primary Assembly

    Genomic

    1. NC_033670.1 Reference Mmur_3.0 Primary Assembly

      Range
      32572413..32678497 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_020289757.1 → XP_020145346.1  hepatocyte growth factor receptor isoform X3

      UniProtKB/TrEMBL
      A0A8B7XC13
      Conserved Domains (7) summary
      smart00429
      Location:408 → 504
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:227 → 310
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:133 → 226
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:652 → 913
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:89 → 131
      PSI; Plexin repeat
      cl15674
      Location:312 → 407
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
      cl15693
      Location:1 → 86
      Sema; The Sema domain, a protein interacting module, of semaphorins and plexins

    2. XM_012761102.2 → XP_012616556.1  hepatocyte growth factor receptor isoform X2

      UniProtKB/TrEMBL
      A0A8B7G369, A0A8C5XAU8
      Related
      ENSMICP00000047081.1, ENSMICT00000060636.1
      Conserved Domains (8) summary
      cd11278
      Location:25 → 517
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00429
      Location:839 → 935
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:658 → 741
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:564 → 657
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1036 → 1297
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam01437
      Location:520 → 562
      PSI; Plexin repeat
      pfam07714
      Location:1032 → 1291
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:743 → 838
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

    3. XM_012761101.2 → XP_012616555.1  hepatocyte growth factor receptor isoform X1

      See identical proteins and their annotated locations for XP_012616555.1

      UniProtKB/Swiss-Prot
      Q2QL89
      UniProtKB/TrEMBL
      A0A8C5XAU8
      Related
      ENSMICP00000048273.1, ENSMICT00000062442.1
      Conserved Domains (8) summary
      cd11278
      Location:25 → 517
      Sema_MET; The Sema domain, a protein interacting module, of MET (also called hepatocyte growth factor receptor, HGFR)
      smart00423
      Location:520 → 562
      PSI; domain found in Plexins, Semaphorins and Integrins
      smart00429
      Location:839 → 935
      IPT; ig-like, plexins, transcription factors
      cd01179
      Location:658 → 741
      IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd01180
      Location:564 → 657
      IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...
      cd05058
      Location:1083 → 1344
      PTKc_Met_Ron; Catalytic domain of the Protein Tyrosine Kinases, Met and Ron
      pfam07714
      Location:1079 → 1338
      Pkinase_Tyr; Protein tyrosine kinase
      cl15674
      Location:743 → 838
      IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q2QL89.1 GenPept UniProtKB/Swiss-Prot:Q2QL89

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