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    PAK1 p21 (RAC1) activated kinase 1 [ Homo sapiens (human) ]

    Gene ID: 5058, updated on 14-Nov-2024

    Summary

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    Official Symbol
    PAK1provided by HGNC
    Official Full Name
    p21 (RAC1) activated kinase 1provided by HGNC
    Primary source
    HGNC:HGNC:8590
    See related
    Ensembl:ENSG00000149269 MIM:602590; AllianceGenome:HGNC:8590
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IDDMSSD; p65-PAK; PAKalpha; alpha-PAK
    Summary
    This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
    Expression
    Ubiquitous expression in brain (RPKM 55.5), thyroid (RPKM 19.6) and 23 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See PAK1 in Genome Data Viewer
    Location:
    11q13.5-q14.1
    Exon count:
    27
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (77322017..77530009, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (77254590..77463028, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (77033062..77185139, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene glycerophosphodiester phosphodiesterase domain containing 4 Neighboring gene TOMM20 pseudogene 1 Neighboring gene NANOG hESC enhancer GRCh37_chr11:77106673-77107174 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5303 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5304 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:77159760-77160530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5306 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:77184247-77185163 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:77189428-77189933 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:77190945-77191449 Neighboring gene Sharpr-MPRA regulatory region 3332 Neighboring gene uncharacterized LOC124902722 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5307 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:77270938-77272137 Neighboring gene RNA, U7 small nuclear 59 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Effects of p21-activated kinase 1 inhibition on 11q13-amplified ovarian cancer cells. Prudnikova TY, et al. Oncogene, 2016 Apr 28. PMID 26257058, Free PMC Article
    2. Myricetin suppresses p21-activated kinase 1 in human breast cancer MCF-7 cells through downstream signaling of the β-catenin pathway. Jiao D, et al. Oncol Rep, 2016 Jul. PMID 27122002
    3. P21-activated kinase 1 (Pak1) signaling influences therapeutic outcome in pancreatic cancer. Jagadeeshan S, et al. Ann Oncol, 2016 Aug. PMID 27117533
    4. Pak1, adjuvant tamoxifen therapy, and breast cancer recurrence risk in a Danish population-based study. Ahern TP, et al. Acta Oncol, 2016 Jun. PMID 27056567, Free PMC Article
    5. p21-activated kinase 1 (PAK1) expression correlates with prognosis in solid tumors: A systematic review and meta-analysis. Fang F, et al. Oncotarget, 2016 May 10. PMID 27027431, Free PMC Article

    See all (563) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
      Title: Porocarcinomas with PAK1/2/3 fusions: a series of 12 cases.
    2. Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
      Title: Deubiquitination of CIB1 by USP14 promotes lenvatinib resistance via the PAK1-ERK1/2 axis in hepatocellular carcinoma.
    3. Targetable leukaemia dependency on noncanonical PI3Kgamma signalling.
      Title: Targetable leukaemia dependency on noncanonical PI3Kγ signalling.
    4. PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.
      Title: PAK1 Promotes Inflammation Induced by Sepsis through the Snail/CXCL2 Signaling Pathway.
    5. A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children.
      Title: A PAK1 Mutational Hotspot Within the Regulatory CRIPaK Domain is Associated With Severe Neurodevelopmental Disorders in Children.
    6. PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis.
      Title: PAK1-dependent mechanotransduction enables myofibroblast nuclear adaptation and chromatin organization during fibrosis.
    7. A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
      Title: A Novel CDC42 Variant with Impaired Thymopoiesis, IL-7R Signaling, PAK1 Binding, and TCR Repertoire Diversity.
    8. Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer.
      Title: Clinicopathological significance and the associated signaling pathway of p21-activated kinase 1 (PAK1) in colorectal cancer.
    9. Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma.
      Title: Activation of oncogenic signaling kinase PAK1 by ionising radiation confers an aggressive phenotype in head and neck squamous cell carcinoma.
    10. PAK1 and Therapy Resistance in Melanoma.
      Title: PAK1 and Therapy Resistance in Melanoma.
    Submit: New GeneRIF Correction See all GeneRIFs (310)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Intellectual developmental disorder with macrocephaly, seizures, and speech delay
    MedGen: C4748428 OMIM: 618158 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env DC-SIGN engagement by HIV-1 gp120 on dendritic cell (DC) surface subsequently activates Cdc42, Pak1, and Wasp, leading to an increase in membrane extensions at the DC surface PubMed
    Nef nef The Nef/hnRNPK/PKC-delta/Hck protein complex activates Pak2 activity but inhibits Pak1 activity, which induces paxillin phosphorylation on Ser272/274 and regulates paxillin/TACE association and secretion PubMed
    nef HIV-1 Nef induces phosphorylation of MEK1 at position serine 298, which depends on Pak and Rac activity. The SH3 region mutation 72PXXP/AXXA75 in Nef results in loss of Pak association which decreases Nef-induced MEK1 phosphorylation PubMed
    nef HIV-1 Nef mutants LLAA and delta12-39 significantly impairs downregulation of CD4. Nef LLAA mutant fails to interact with the endocytic machinery and Nef delta12-39 mutant lacks the interaction with the Nef-associated kinase complex PubMed
    nef The mutation of all four glutamates (amino acids 62-65) to alanine in HIV-1 Nef impairs the ability of Nef to regulate p21-activated protein kinase and enhance viral particle infectivity PubMed
    nef HIV-1 Nef binding and activation of the PAK-related kinase and phosphorylation of its substrate (a complex composed of PIX and p95) are readily detected in both infected primary T lymphocytes and macrophages PubMed
    nef HIV-1 Nef-mediated p21-activated kinase (PAK) activation involves the binding of Nef and phosphatidylinositol 3-kinase (PI3K) PubMed
    nef The activation of Nef-associated kinase (NAK; also known as p21-activated kinase 1 or PAK1) by HIV-1 Nef is via the small GTPases Cdc42 and Rac1, suggesting an interaction between Nef and these GTPases PubMed
    nef HIV-1 Nef-mediated activation of a PAK-related kinase correlates with the induction of high virus loads and the development of AIDS in infected rhesus macaques PubMed
    nef The association of HIV-1 Nef with the cellular serine kinase PAK enhances efficient proviral DNA synthesis and virion infectivity PubMed
    nef A cellular serine kinase is found to specifically associate with HIV-1 Nef; proteins of 62 kDa and 72 kDa, which coimmunoprecipitated with Nef, are phosphorylated in in vitro kinase assays PubMed
    Tat tat Uptake of the HIV-1 Tat protein is regulated by PAK1 activity in epithelial cells PubMed
    tat HIV-1 Tat induces actin cytoskeletal rearrangements through p21-activated kinase 1 (PAK1) and downstream activation of the endothelial NADPH oxidase, an effect that is lost by introduction of mutations into the Tat cysteine-rich or basic domains PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC130000, MGC130001

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables collagen binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-tubulin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity EXP
    Inferred from Experiment
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity TAS
    Traceable Author Statement
    more info
    		  
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to small GTPase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in Fc-gamma receptor signaling pathway involved in phagocytosis TAS
    Traceable Author Statement
    more info
    		  
    NOT involved_in MAPK cascade IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in branching morphogenesis of an epithelial tube IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within cell migration IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to starvation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in ephrin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in exocytosis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in hepatocyte growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of cell proliferation involved in contact inhibition IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of JUN kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of cell migration IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of intracellular estrogen receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of microtubule nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of microtubule polymerization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of stress fiber assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein localization to cytoplasmic stress granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of actin cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of axonogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stimulatory C-type lectin receptor signaling pathway TAS
    Traceable Author Statement
    more info
    		  
    involved_in wound healing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Z disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in actin filament IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cell-cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in intercalated disc ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in ruffle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    serine/threonine-protein kinase PAK 1
    Names
    STE20 homolog, yeast
    p21 protein (Cdc42/Rac)-activated kinase 1
    p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)
    p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related)
    NP_001122092.1
    NP_001363197.1
    NP_001363198.1
    NP_001363199.1
    NP_001363200.1
    NP_001363201.1
    NP_001363202.1
    NP_001363203.1
    NP_001363204.1
    NP_001363205.1
    NP_001363206.1
    NP_001363207.1
    NP_001363208.1
    NP_001363209.1
    NP_001363210.1
    NP_001363211.1
    NP_001363212.1
    NP_001363213.1
    NP_001363214.1
    NP_001363215.1
    NP_001363216.1
    NP_001363217.1
    NP_001363218.1
    NP_001363219.1
    NP_001363220.1
    NP_001363221.1
    NP_001363222.1
    NP_001363223.1
    NP_001363224.1
    NP_001363230.1
    NP_001363231.1
    NP_001363232.1
    NP_001363233.1
    NP_001363234.1
    NP_002567.3
    XP_024304325.1
    XP_024304326.1
    XP_024304327.1
    XP_024304328.1
    XP_047283002.1
    XP_047283003.1
    XP_047283004.1
    XP_047283005.1
    XP_047283006.1
    XP_047283007.1
    XP_047283008.1
    XP_047283009.1
    XP_047283010.1
    XP_054224984.1
    XP_054224985.1
    XP_054224986.1
    XP_054224987.1
    XP_054224988.1
    XP_054224989.1
    XP_054224990.1
    XP_054224991.1
    XP_054224992.1
    XP_054224993.1
    XP_054224994.1
    XP_054224995.1
    XP_054224996.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029900.3 RefSeqGene

      Range
      60915..212992
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001128620.2 → NP_001122092.1  serine/threonine-protein kinase PAK 1 isoform 1

      See identical proteins and their annotated locations for NP_001122092.1

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Related
      ENSP00000278568.4, ENST00000278568.8
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    2. NM_001376268.1 → NP_001363197.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    3. NM_001376269.1 → NP_001363198.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    4. NM_001376270.1 → NP_001363199.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    5. NM_001376271.1 → NP_001363200.1  serine/threonine-protein kinase PAK 1 isoform 1

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS44687.1
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    6. NM_001376272.1 → NP_001363201.1  serine/threonine-protein kinase PAK 1 isoform 3

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:256 → 551
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 135
      PBD; P21-Rho-binding domain

    7. NM_001376273.1 → NP_001363202.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    8. NM_001376274.1 → NP_001363203.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    9. NM_001376275.1 → NP_001363204.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    10. NM_001376276.1 → NP_001363205.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    11. NM_001376277.1 → NP_001363206.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    12. NM_001376278.1 → NP_001363207.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    13. NM_001376279.1 → NP_001363208.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    14. NM_001376280.1 → NP_001363209.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    15. NM_001376281.1 → NP_001363210.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    16. NM_001376282.1 → NP_001363211.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    17. NM_001376283.1 → NP_001363212.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    18. NM_001376284.1 → NP_001363213.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    19. NM_001376285.1 → NP_001363214.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    20. NM_001376286.1 → NP_001363215.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    21. NM_001376287.1 → NP_001363216.1  serine/threonine-protein kinase PAK 1 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    22. NM_001376288.1 → NP_001363217.1  serine/threonine-protein kinase PAK 1 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS91545.1
      UniProtKB/TrEMBL
      A8KAN3, B3KNX7
      Related
      ENSP00000433423.1, ENST00000530617.5
      Conserved Domains (2) summary
      cd06647
      Location:262 → 518
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    23. NM_001376289.1 → NP_001363218.1  serine/threonine-protein kinase PAK 1 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:262 → 471
      PKc_like; Protein Kinases, catalytic domain

    24. NM_001376290.1 → NP_001363219.1  serine/threonine-protein kinase PAK 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:249 → 503
      PKc_like; Protein Kinases, catalytic domain

    25. NM_001376291.1 → NP_001363220.1  serine/threonine-protein kinase PAK 1 isoform 6

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:249 → 503
      PKc_like; Protein Kinases, catalytic domain

    26. NM_001376292.1 → NP_001363221.1  serine/threonine-protein kinase PAK 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain
      cl21453
      Location:249 → 498
      PKc_like; Protein Kinases, catalytic domain

    27. NM_001376293.1 → NP_001363222.1  serine/threonine-protein kinase PAK 1 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain
      cl21453
      Location:249 → 498
      PKc_like; Protein Kinases, catalytic domain

    28. NM_001376294.1 → NP_001363223.1  serine/threonine-protein kinase PAK 1 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:259 → 472
      PKc_like; Protein Kinases, catalytic domain

    29. NM_001376295.1 → NP_001363224.1  serine/threonine-protein kinase PAK 1 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain
      cl21453
      Location:274 → 485
      PKc_like; Protein Kinases, catalytic domain

    30. NM_001376301.1 → NP_001363230.1  serine/threonine-protein kinase PAK 1 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:166 → 461
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

    31. NM_001376302.1 → NP_001363231.1  serine/threonine-protein kinase PAK 1 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Consensus CDS
      CCDS91544.1
      UniProtKB/TrEMBL
      B7Z3K0, E9PM17
      Related
      ENSP00000433211.1, ENST00000528203.5
      Conserved Domains (1) summary
      cd06647
      Location:164 → 419
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase

    32. NM_001376303.1 → NP_001363232.1  serine/threonine-protein kinase PAK 1 isoform 12

      Status: REVIEWED

      Source sequence(s)
      AP000486
      Conserved Domains (2) summary
      cd01093
      Location:73 → 118
      CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
      cl21453
      Location:198 → 448
      PKc_like; Protein Kinases, catalytic domain

    33. NM_001376304.1 → NP_001363233.1  serine/threonine-protein kinase PAK 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:151 → 446
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

    34. NM_001376305.1 → NP_001363234.1  serine/threonine-protein kinase PAK 1 isoform 13

      Status: REVIEWED

      Source sequence(s)
      AP000486
      UniProtKB/TrEMBL
      B7Z3K0
      Conserved Domains (1) summary
      cd06654
      Location:151 → 446
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1

    35. NM_002576.5 → NP_002567.3  serine/threonine-protein kinase PAK 1 isoform 2

      See identical proteins and their annotated locations for NP_002567.3

      Status: REVIEWED

      Source sequence(s)
      AP000486, AP003680
      Consensus CDS
      CCDS8250.1
      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Related
      ENSP00000348696.4, ENST00000356341.8
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    RNA

    1. NR_164797.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000486

    2. NR_164798.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000486

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      77322017..77530009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024448560.2 → XP_024304328.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79
      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06654
      Location:249 → 544
      STKc_PAK1; Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1
      pfam00786
      Location:74 → 132
      PBD; P21-Rho-binding domain

    2. XM_047427054.1 → XP_047283010.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

    3. XM_047427049.1 → XP_047283005.1  serine/threonine-protein kinase PAK 1 isoform X3

    4. XM_047427051.1 → XP_047283007.1  serine/threonine-protein kinase PAK 1 isoform X3

    5. XM_047427048.1 → XP_047283004.1  serine/threonine-protein kinase PAK 1 isoform X3

    6. XM_024448559.2 → XP_024304327.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    7. XM_047427053.1 → XP_047283009.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

    8. XM_047427050.1 → XP_047283006.1  serine/threonine-protein kinase PAK 1 isoform X3

    9. XM_024448557.2 → XP_024304325.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    10. XM_047427047.1 → XP_047283003.1  serine/threonine-protein kinase PAK 1 isoform X2

    11. XM_047427046.1 → XP_047283002.1  serine/threonine-protein kinase PAK 1 isoform X1

    12. XM_047427052.1 → XP_047283008.1  serine/threonine-protein kinase PAK 1 isoform X3

    13. XM_024448558.2 → XP_024304326.1  serine/threonine-protein kinase PAK 1 isoform X3

      UniProtKB/TrEMBL
      A8KAN3
      Conserved Domains (2) summary
      cd06647
      Location:262 → 517
      STKc_PAK_I; Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase
      pfam00786
      Location:74 → 128
      PBD; P21-Rho-binding domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      77254590..77463028 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054369020.1 → XP_054224995.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

    2. XM_054369019.1 → XP_054224994.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

    3. XM_054369012.1 → XP_054224987.1  serine/threonine-protein kinase PAK 1 isoform X3

    4. XM_054369017.1 → XP_054224992.1  serine/threonine-protein kinase PAK 1 isoform X3

    5. XM_054369011.1 → XP_054224986.1  serine/threonine-protein kinase PAK 1 isoform X3

    6. XM_054369021.1 → XP_054224996.1  serine/threonine-protein kinase PAK 1 isoform X4

      UniProtKB/Swiss-Prot
      O75561, Q13153, Q13567, Q32M53, Q32M54, Q86W79

    7. XM_054369013.1 → XP_054224988.1  serine/threonine-protein kinase PAK 1 isoform X3

    8. XM_054369014.1 → XP_054224989.1  serine/threonine-protein kinase PAK 1 isoform X3

    9. XM_054369016.1 → XP_054224991.1  serine/threonine-protein kinase PAK 1 isoform X3

    10. XM_054369010.1 → XP_054224985.1  serine/threonine-protein kinase PAK 1 isoform X2

    11. XM_054369009.1 → XP_054224984.1  serine/threonine-protein kinase PAK 1 isoform X1

    12. XM_054369018.1 → XP_054224993.1  serine/threonine-protein kinase PAK 1 isoform X3

    13. XM_054369015.1 → XP_054224990.1  serine/threonine-protein kinase PAK 1 isoform X3

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q13153.2 GenPept UniProtKB/Swiss-Prot:Q13153

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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