CSF2 colony stimulating factor 2 [Capra hircus (goat)] - Gene

Summary

Gene symbol: CSF2
Gene description: colony stimulating factor 2
See related: EnsemblRapid:ENSCHIG00000030659
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Capra hircus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Capra
Also known as: GM-CSF
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 7

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
102	current	ASM170441v1 (GCF_001704415.1)	7	NC_030814.1 (88163476..88165829)
101	previous assembly	CHIR_1.0 (GCF_000317765.1)	7	NC_022299.1 (18847081..18849443, complement)

Chromosome 7 - NC_030814.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data indicate that differentially expressed IL-17, IL-22, and IL-23 levels are associated with K-ras in a stage-specific fashion along colorectal cancer progression and an association was established between mutant K-ras and GM-CSF and IFN-gamma.
Title: Differential expression of IL-17, 22 and 23 in the progression of colorectal cancer in patients with K-ras mutation: Ras signal inhibition and crosstalk with GM-CSF and IFN-γ.

Submit: New GeneRIF Correction

General gene information

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Markers

CSF2-2 (e-PCR)
- UniSTS:254052

CSF2sts1 (e-PCR)
- UniSTS:258486

CSF2 (e-PCR)
- UniSTS:253932

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables cytokine activity	IEA Inferred from Electronic Annotation more info	PubMed
enables granulocyte macrophage colony-stimulating factor receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables growth factor activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in myeloid cell differentiation	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: granulocyte-macrophage colony-stimulating factor

Names: granulocyte-macrophage colony stimulating factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001285570.1 → NP_001272499.1 granulocyte-macrophage colony-stimulating factor precursor

See identical proteins and their annotated locations for NP_001272499.1

Status: PROVISIONAL

Source sequence(s)

DQ010419

UniProtKB/TrEMBL

Q52GZ7

Related

ENSCHIP00000037527.1, ENSCHIT00000064640.1

Conserved Domains (1) summary

cd00040
Location:18 → 138

CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...

RefSeqs of Annotated Genomes: Capra hircus Annotation Release 102 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ASM170441v1 Primary Assembly

Genomic

NC_030814.1 Reference ASM170441v1 Primary Assembly

Range

88163476..88165829

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_013965265.2 → XP_013820719.1 granulocyte-macrophage colony-stimulating factor isoform X1

UniProtKB/TrEMBL

Q52GZ7

Conserved Domains (1) summary

cd00040
Location:18 → 138

CSF2; Granulocyte Macrophage Colony Stimulating Factor (GM-CSF) is a member of the large family of polypeptide growth factors called cytokines. It stimulates a wide variety of hematopoietic and nonhematopoietic cell types via binding to members of the cytokine ...