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    E1B control protein E1B 19K;control protein E1B 55K [ Human mastadenovirus C ]

    Gene ID: 2652981, updated on 6-Jun-2024

    Summary

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    Gene symbol
    E1B
    Gene description
    control protein E1B 19K;control protein E1B 55K
    Locus tag
    HAdVC_gp02
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Human mastadenovirus C (serotype: Human adenovirus 2, acronym: HAdV-2, acronym: HAdV-C, nat-host: Homo sapiens)
    Lineage
    Viruses; Varidnaviria; Bamfordvirae; Preplasmiviricota; Tectiliviricetes; Rowavirales; Adenoviridae; Mastadenovirus
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    Genomic context

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    Sequence:
    NC_001405.1 (1669..4061)

    NC_001405.1Genomic Context describing neighboring genes Neighboring gene control protein E1A;control protein E1A 243R Neighboring gene encapsidation protein IVa2 Neighboring gene capsid protein IX Neighboring gene DNA polymerase;terminal protein precursor pTP Neighboring gene capsid protein precursor pIIIa;encapsidation protein 52K;protein 13.6K Neighboring gene core protein V;core protein precursor pVII;core protein precursor pX;penton base Neighboring gene capsid protein precursor pVI;hexon;protease Neighboring gene capsid protein precursor pVIII;encapsidation protein 22K;hexon assembly protein 100K;protein 33K Neighboring gene fiber Neighboring gene miscRNA Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001405.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism. Tejera B, et al. PLoS One, 2019. PMID 30943256, Free PMC Article
    2. The transmembrane domain of the adenovirus E3/19K protein acts as an endoplasmic reticulum retention signal and contributes to intracellular sequestration of major histocompatibility complex class I molecules. Sester M, et al. J Virol, 2013 Jun. PMID 23514889, Free PMC Article
    3. Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substrates. Blanchette P, et al. J Virol, 2013 May. PMID 23408624, Free PMC Article
    4. The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication. Chahal JS, et al. J Virol, 2013 Apr. PMID 23388716, Free PMC Article
    5. Timely synthesis of the adenovirus type 5 E1B 55-kilodalton protein is required for efficient genome replication in normal human cells. Chahal JS, et al. J Virol, 2012 Mar. PMID 22278242, Free PMC Article

    See all (20) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes.
      Title: Differential Regulation of Cellular FAM111B by Human Adenovirus C Type 5 E1 Oncogenes.
    2. The interaction of E1B 55kDa with RNA was found to correlate with timely and efficient viral DNA replication and viral late mRNA accumulation and splicing.
      Title: The human adenovirus type 5 E1B 55kDa protein interacts with RNA promoting timely DNA replication and viral late mRNA metabolism.
    3. Adenovirus type 5 E1A and E1B is supporting the full human cytomegalovirus replication cycle.
      Title: Adenovirus E1A/E1B Transformed Amniotic Fluid Cells Support Human Cytomegalovirus Replication.
    4. KAP1 binds to the viral E1B-55K protein, promoting its SUMO modification, therefore illustrating a crucial step for efficient viral replication.
      Title: KAP1 Is a Host Restriction Factor That Promotes Human Adenovirus E1B-55K SUMO Modification.
    5. The adenoviral E1B-55K protein prevents entry into mitosis.
      Title: Adenovirus replaces mitotic checkpoint controls.
    6. The E1B-55K or E4orf3 proteins independently prevented nuclear fragmentation subsequent to release of AIF from the mitochondria, possibly by altering the intracellular distribution of PAR-modified proteins.
      Title: E1B and E4 oncoproteins of adenovirus antagonize the effect of apoptosis inducing factor.
    7. E3/19K transmembrane domain acts as a signal for static ER retention that significantly enhances HLA complex formation..
      Title: The transmembrane domain of the adenovirus E3/19K protein acts as an endoplasmic reticulum retention signal and contributes to intracellular sequestration of major histocompatibility complex class I molecules.
    8. E1B55K is not required for efficient degradation of nuclear substrates.
      Title: Aggresome formation by the adenoviral protein E1B55K is not conserved among adenovirus species and is not required for efficient degradation of nuclear substrates.
    9. The E2 enzyme Ubc9 is an interaction partner of E1B-55K, providing a possible molecular explanation for SUMO-dependent modulation of cellular target proteins.
      Title: Cross-talk between phosphorylation and SUMOylation regulates transforming activities of an adenoviral oncoprotein.
    10. These observations indicate that the E1B 55-kDa protein is not sufficient to establish transcriptional repression of interferon-inducible genes.
      Title: The repression domain of the E1B 55-kilodalton protein participates in countering interferon-induced inhibition of adenovirus replication.
    Submit: New GeneRIF Correction See all GeneRIFs (19)

    General gene information

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    Homology

    prim_transcript

    • Loc: 1699-4061 experiment = transcript mapping
    • Loc: 3576-4061 experiment = transcript mapping

    regulatory

    • Loc: 1669-1674 regulatory_class = TATA_box
    • Loc: 3545-3550 regulatory_class = TATA_box
    • Loc: 4029-4034 regulatory_class = polyA_signal_sequence

    General protein information

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    Preferred Names
    control protein E1B 19K;control protein E1B 55K
    NP_040510.1
    • genus-specific

    VOG classification

    Description:

    • VOGd0003 [R] Mastadenovirus small T-antigen
    • Regulation of Cellular Metabolism
    NP_040511.1
    • genus-specific

    VOG classification

    Description:

    • VOGd0004 [R] Adenovirus large T-antigen
    • Regulation of Cellular Metabolism

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001405.1 Reference assembly

      Range
      1669..4061
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_040510.1 control protein E1B 19K [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040510.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03247
      UniProtKB/TrEMBL
      A0A1U9ALK7, A0A3G8W3H5, A0A3Q9HJ54, A0A5J6SGA9, A0AAF0YXA5, E1U5L6, J9Z5H0
      Conserved Domains (1) summary
      pfam01691
      Location:1 → 135
      Adeno_E1B_19K; Adenovirus E1B 19K protein / small t-antigen

    2. NP_040511.1 control protein E1B 55K [Human mastadenovirus C]

      See identical proteins and their annotated locations for NP_040511.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P03244, Q67789, Q67790
      UniProtKB/TrEMBL
      A0A1U9ALK1, A0A3G8W5J7, A0A3Q9HK74, A0A3Q9HKV6, A0A5J6SFB2, A0AAF0YXF9, A0AAF0Z291, E1U5L8, E7DY82, J9Z4J9
      Conserved Domains (2) summary
      pfam04623
      Location:1 → 44
      Adeno_E1B_55K_N; Adenovirus E1B protein N-terminus
      pfam01696
      Location:110 → 492
      Adeno_E1B_55K; Adenovirus EB1 55K protein / large t-antigen
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    AAA92200.1
    AAA92202.1

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