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    TBSVgp5 p19 protein [ Tomato bushy stunt virus ]

    Gene ID: 1493957, updated on 18-Aug-2023

    Summary

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    Gene symbol
    TBSVgp5
    Gene description
    p19 protein
    Locus tag
    TBSVgp5
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Tomato bushy stunt virus (strain: cherry)
    Lineage
    Viruses; ssRNA viruses; ssRNA positive-strand viruses, no DNA stage; Tombusviridae; Tombusvirus
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    Genomic context

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    Sequence:
    NC_001554.1 (3888..4406)

    NC_001554.1Genomic Context describing neighboring genes Neighboring gene p33 protein Neighboring gene p92 protein Neighboring gene p41 capsid protein Neighboring gene p22 protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001554.1

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular Dynamics. Allison JR, et al. PLoS One, 2016. PMID 26871901, Free PMC Article
    2. Studying the RNA silencing pathway with the p19 protein. Danielson DC, et al. FEBS Lett, 2013 Apr 17. PMID 23376479
    3. Transient expression of antibodies in suspension plant cell suspension cultures is enhanced when co-transformed with the tomato bushy stunt virus p19 viral suppressor of gene silencing. Boivin EB, et al. Biotechnol Prog, 2010 Nov-Dec. PMID 20859930
    4. Diverse and newly recognized effects associated with short interfering RNA binding site modifications on the Tomato bushy stunt virus p19 silencing suppressor. Hsieh YC, et al. J Virol, 2009 Mar. PMID 19052093, Free PMC Article
    5. Biological relevance of a stable biochemical interaction between the tombusvirus-encoded P19 and short interfering RNAs. Omarov R, et al. J Virol, 2006 Mar. PMID 16501109, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Both observed variation and potential variation (where a non-synonymous change to p19 would be synonymous for the overprinted movement protein) does not significantly impact protein structure or RNA binding.
      Title: Positive Selection or Free to Vary? Assessing the Functional Significance of Sequence Change Using Molecular Dynamics.
    2. Data indicate that p19 exhibits size-specific and sequence-independent binding of its small RNA ligand.
      Title: Studying the RNA silencing pathway with the p19 protein.
    3. Evidently the contribution of capsid protein or P19 protein in establishing systemic infections depends on the point-of-entry of Tomato bushy stunt virus in the plants.
      Title: Differential requirements for Tombusvirus coat protein and P19 in plants following leaf versus root inoculation.
    4. The results demonstrate that transient co-transformation of plant cell suspension culture with two transformation vectors is feasible and that the use of the viral suppressor of silencing p19 significantly raises the production of the protein of interest.
      Title: Transient expression of antibodies in suspension plant cell suspension cultures is enhanced when co-transformed with the tomato bushy stunt virus p19 viral suppressor of gene silencing.
    5. Substitutions on P19 that compromised siRNA binding not only affected systemic invasion and symptom development but also resulted in newly recognized effects on the integrity of virus and host material in a plant species-dependent manner.
      Title: Diverse and newly recognized effects associated with short interfering RNA binding site modifications on the Tomato bushy stunt virus p19 silencing suppressor.
    6. P19 suppresses a common step in RNA silencing (innate immunity) that is downstream of small RNA maturation
      Title: HIV-1 Tat RNA silencing suppressor activity is conserved across kingdoms and counteracts translational repression of HIV-1.
    7. activity hindered by defective interfering RNA
      Title: Defective interfering RNA hinders the activity of a tombusvirus-encoded posttranscriptional gene silencing suppressor.
    8. involved in suppression of posttranscriptional gene silencing, virus movement, and symptom induction.
      Title: Relocalization of nuclear ALY proteins to the cytoplasm by the tomato bushy stunt virus P19 pathogenicity protein.
    9. This is the first clear demonstration of a direct correlation between a novel structurally orchestrated siRNA binding of an RNAi suppressor, P19 protein, and its roles in viral pathogenesis.
      Title: Biological relevance of a stable biochemical interaction between the tombusvirus-encoded P19 and short interfering RNAs.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    General protein information

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    Preferred Names
    p19 protein

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001554.1 Reference assembly

      Range
      3888..4406
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NP_062901.1 p19 protein [Tomato bushy stunt virus]

      See identical proteins and their annotated locations for NP_062901.1

      Status: PROVISIONAL

      UniProtKB/Swiss-Prot
      P11690
      UniProtKB/TrEMBL
      Q712F7, Q712F9, Q9ICP9, Q9ICQ0
      Conserved Domains (1) summary
      pfam03220
      Location:1 → 171
      Tombus_P19; Tombusvirus P19 core protein
    Nucleotide Protein
    Heading Accession and Version

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