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    ar.L androgen receptor L homeolog [ Xenopus laevis (African clawed frog) ]

    Gene ID: 399456, updated on 4-Nov-2024

    Summary

    Official Symbol
    ar.L
    Official Full Name
    androgen receptor L homeolog
    Primary source
    Xenbase:XB-GENE-479433
    Locus tag
    XELAEV_18002878mg
    See related
    EnsemblRapid:ENSXLAG00005031532 AllianceGenome:Xenbase:XB-GENE-479433
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Xenopus laevis
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
    Also known as
    ar; ADR; Xl alpha AR
    Summary
    Predicted to enable several functions, including estrogen response element binding activity; nuclear receptor activity; and zinc ion binding activity. Predicted to act upstream of or within androgen receptor signaling pathway; male gonad development; and positive regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in musculoskeletal system; nervous system; respiratory system; and sensory system. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; disorder of sexual development (multiple); reproductive organ cancer (multiple); and spinal muscular atrophy (multiple). Orthologous to human AR (androgen receptor). [provided by Alliance of Genome Resources, Nov 2024]
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    Genomic context

    See ar.L in Genome Data Viewer
    Location:
    chromosome: 8L
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 8L NC_054385.1 (30541025..30689464, complement)
    100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) Unplaced Scaffold NW_016694828.1 (812014..958903)

    Chromosome 8L - NC_054385.1Genomic Context describing neighboring genes Neighboring gene probable G-protein coupled receptor 83 Neighboring gene oligophrenin 1 L homeolog Neighboring gene Yip1 domain family member 6 L homeolog Neighboring gene uncharacterized LOC121396969 Neighboring gene ectodysplasin A2 receptor L homeolog

    Genomic regions, transcripts, and products

    General gene information

    Gene Ontology Provided by Xenbase

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables estrogen response element binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nuclear receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    androgen receptor; androgen receptor L homeolog
    Names
    androgen receptor (dihydrotestosterone receptor; testicular feminization; spinal and bulbar muscular atrophy; Kennedy disease) L homeolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference Xenopus_laevis_v10.1 Primary Assembly

    Genomic

    1. NC_054385.1 Reference Xenopus_laevis_v10.1 Primary Assembly

      Range
      30541025..30689464 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_041572639.1XP_041428573.1  androgen receptor

      UniProtKB/TrEMBL
      A0A8J1LG91, B7ZS00, P70048
      Related
      ENSXLAP00005094469.1, ENSXLAT00005096171.1
      Conserved Domains (3) summary
      cd07073
      Location:542787
      NR_LBD_AR; Ligand binding domain of the nuclear receptor androgen receptor, ligand activated transcription regulator
      cd07173
      Location:423504
      NR_DBD_AR; DNA-binding domain of androgen receptor (AR) is composed of two C4-type zinc fingers
      pfam02166
      Location:6345
      Androgen_recep; Androgen receptor

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001090884.1: Suppressed sequence

      Description
      NM_001090884.1: This RefSeq was removed because it is a nonsense-mediated mRNA decay (NMD) candidate.