GAGE12I G antigen 12I [Homo sapiens (human)] - Gene

Summary

Official Symbol: GAGE12Iprovided by HGNC
Official Full Name: G antigen 12Iprovided by HGNC
Primary source: HGNC:HGNC:4105
See related: MIM:300637; AllianceGenome:HGNC:4105
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: AL4; CT4.7; GAGE7B; GAGE-7B
Summary: This gene belongs to a family of genes that are expressed in a variety of tumors but not in normal tissues, except for the testis. The sequences of the family members are highly related but differ by scattered nucleotide substitutions. The antigenic peptide YYWPRPRRY, which is also encoded by several other family members, is recognized by autologous cytolytic T lymphocytes. [provided by RefSeq, Jul 2008]
Annotation information: Annotation category: suggests misassembly; not in current annotation release
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Genomic context

Location:: Xp11.23

Annotation release	Status	Assembly	Chr	Location
RS_2024_09	latest, but not current	GRCh37.p13 (GCF_000001405.25)	X	NC_000023.10 (49216677..49223943)

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

GAGE7B significantly promotes gastric cancer progression by upregulating the p38delta/pMAPKAPK2/pHSP27 pathway, but it is negatively regulated by miR-30c.
Title: GAGE7B promotes tumor metastasis and growth via activating the p38δ/pMAPKAPK2/pHSP27 pathway in gastric cancer.
The metazoan transcriptional regulator, Germ cell-less (GCL), as an interaction partner of GAGE12I.
Title: GAGE cancer-germline antigens are recruited to the nuclear envelope by germ cell-less (GCL).

Submit: New GeneRIF Correction

Variation

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See variants in ClinVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

NoName (e-PCR)
- UniSTS:481091

NoName (e-PCR)
- UniSTS:481101

NoName (e-PCR)
- UniSTS:482134

NoName (e-PCR)
- UniSTS:487065

NoName (e-PCR)
- UniSTS:494525

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

General protein information

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Preferred Names: G antigen 12I

Names: G antigen 12G; G antigen 7B; cancer/testis antigen 4.7; g antigen 12F/G/I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.