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    ESRRG estrogen related receptor gamma [ Homo sapiens (human) ]

    Gene ID: 2104, updated on 2-Nov-2024

    Summary

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    Official Symbol
    ESRRGprovided by HGNC
    Official Full Name
    estrogen related receptor gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3474
    See related
    Ensembl:ENSG00000196482 MIM:602969; AllianceGenome:HGNC:3474
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ERR3; ERRg; NR3B3; ERRgamma; ERR-gamma
    Summary
    This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]
    Expression
    Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ESRRG in Genome Data Viewer
    Location:
    1q41
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (216503246..217137702, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (215743580..216378774, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (216676588..217311044, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene usherin Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216419825-216420431 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4209 Neighboring gene USH2A antisense RNA 1 Neighboring gene mitochondrial ribosomal protein S18B pseudogene 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:216566486-216566587 Neighboring gene uncharacterized LOC107985596 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:216659268-216659830 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216771579-216772306 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:216773848-216774416 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1817 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2536 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4286 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4347 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4384 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr1:216913568-216914135 Neighboring gene uncharacterized LOC124904512 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:217086328-217086517 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4410 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217168113-217168612 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_4481 Neighboring gene Sharpr-MPRA regulatory region 1545 Neighboring gene MPRA-validated peak697 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217307024-217307790 Neighboring gene Sharpr-MPRA regulatory region 11696 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217309339-217310050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217310051-217310761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:217311473-217312183 Neighboring gene uncharacterized LOC107985461 Neighboring gene uncharacterized LOC105372920

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Structural evidence for endocrine disruptor bisphenol A binding to human nuclear receptor ERR gamma. Matsushima A, et al. J Biochem, 2007 Oct. PMID 17761695
    2. ERRgamma tethers strongly bisphenol A and 4-alpha-cumylphenol in an induced-fit manner. Matsushima A, et al. Biochem Biophys Res Commun, 2008 Aug 29. PMID 18582436
    3. ESRRG promoter hypermethylation as a diagnostic and prognostic biomarker in laryngeal squamous cell carcinoma. Shen Z, et al. J Clin Lab Anal, 2019 Jul. PMID 31002184, Free PMC Article
    4. Polymorphic AAAG repeat length in estrogen-related receptor gamma (ERRγ) and risk of breast cancer in Iranian women. Karimi P, et al. Cancer Invest, 2013 Nov. PMID 24125170
    5. Receptor binding characteristics of the endocrine disruptor bisphenol A for the human nuclear estrogen-related receptor gamma. Chief and corroborative hydrogen bonds of the bisphenol A phenol-hydroxyl group with Arg316 and Glu275 residues. Liu X, et al. FEBS J, 2007 Dec. PMID 18005256

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Metabolic regulator ERRgamma governs gastric stem cell differentiation into acid-secreting parietal cells.
      Title: Metabolic regulator ERRγ governs gastric stem cell differentiation into acid-secreting parietal cells.
    2. ERRalpha and ERRgamma coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
      Title: ERRα and ERRγ coordinate expression of genes associated with Alzheimer's disease, inhibiting DKK1 to suppress tau phosphorylation.
    3. ERRgamma-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
      Title: ERRγ-inducible FGF23 promotes alcoholic liver injury through enhancing CYP2E1 mediated hepatic oxidative stress.
    4. Estrogen receptor-related receptor gamma uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
      Title: Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
    5. Role of Estrogen-Related Receptor gamma and PGC-1alpha/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
      Title: Role of Estrogen-Related Receptor γ and PGC-1α/SIRT3 Pathway in Early Brain Injury After Subarachnoid Hemorrhage.
    6. Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/beta-catenin signaling.
      Title: Nuclear receptor estrogen-related receptor gamma suppresses colorectal cancer aggressiveness by regulating Wnt/β-catenin signaling.
    7. Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placentadagger.
      Title: Sex-specific effects of bisphenol A on the signaling pathway of ESRRG in the human placenta†.
    8. The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
      Title: The nuclear receptor ERR cooperates with the cardiogenic factor GATA4 to orchestrate cardiomyocyte maturation.
    9. Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
      Title: Lupus susceptibility gene Esrrg modulates regulatory T cells through mitochondrial metabolism.
    10. Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
      Title: Estrogen-related receptor-gamma influences Helicobacter pylori infection by regulating TFF1 in gastric cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (78)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.
    EBI GWAS Catalog
    Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.
    EBI GWAS Catalog
    Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.
    EBI GWAS Catalog
    Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
    EBI GWAS Catalog
    Genome-wide association scan for survival on dialysis in African-Americans with type 2 diabetes.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ16023, KIAA0832, DKFZp781L1617

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables AF-2 domain binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables estrogen response element binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear steroid receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables steroid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in nuclear receptor-mediated steroid hormone signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    estrogen-related receptor gamma
    Names
    ERR gamma-2
    estrogen receptor-related protein 3
    nuclear receptor subfamily 3 group B member 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029784.1 RefSeqGene

      Range
      419327..639505
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001134285.3 → NP_001127757.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001127757.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, BX647076
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355907.2, ENST00000366940.6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    2. NM_001243505.2 → NP_001230434.1  estrogen-related receptor gamma isoform 3

      See identical proteins and their annotated locations for NP_001230434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks three exons from the 5' end but has alternate three 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (3) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, BM723962, BU752915
      UniProtKB/Swiss-Prot
      P62508
      Conserved Domains (1) summary
      cd06946
      Location:1 → 205
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors

    3. NM_001243506.2 → NP_001230435.1  estrogen-related receptor gamma isoform 4

      See identical proteins and their annotated locations for NP_001230435.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two exons from the 5' end but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (4) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AB020639, AK298851, BP349857, BU752915
      UniProtKB/TrEMBL
      B7Z5E9
      Conserved Domains (2) summary
      cd06946
      Location:52 → 271
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:1 → 33
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    4. NM_001243507.2 → NP_001230436.1  estrogen-related receptor gamma isoform 5

      See identical proteins and their annotated locations for NP_001230436.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks a 5' exon and an internal in-frame exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (5, also known as ERRgamma3) is shorter at the N-terminus and lacks an internal segment corresponding to the second zinc finger motif of the DNA binding domain (PMID:16460929), compared to isoform 1.
      Source sequence(s)
      AB020639, AB362218, AC096634, AK131193, BU752915, DB220304
      Consensus CDS
      CCDS58060.1
      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000418629.1, ENST00000463665.5
      Conserved Domains (2) summary
      cd06946
      Location:175 → 394
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cl02596
      Location:99 → 156
      NR_DBD_like; DNA-binding domain of nuclear receptors is composed of two C4-type zinc fingers

    5. NM_001243509.2 → NP_001230438.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230438.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AC096634, BU752915, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000417374.1, ENST00000493748.5
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    6. NM_001243510.3 → NP_001230439.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230439.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388457, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000419594.1, ENST00000493603.5
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    7. NM_001243511.3 → NP_001230440.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230440.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) uses an alternate exon structure in the 5' UTR and 5' coding region, compared to variant 1. This results in a distinct 5' UTR and use of a downstream in-frame start codon. The encoded isoform (2) has a shorter N-terminus compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AY388460, BU752915, BX647076, DA293919
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    8. NM_001243512.1 → NP_001230441.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230441.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks the 5' exon but has more than three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AK131193, AY388458, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000419155.1, ENST00000487276.5
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    9. NM_001243513.1 → NP_001230442.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230442.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) lacks the 5' exon but has more than two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AB362218, AY388459, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355905.2, ENST00000366938.6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    10. NM_001243514.2 → NP_001230443.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230443.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14) lacks the 5' exon but has an alternate 5' exon and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AC096635, AY388461, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000353108.3, ENST00000360012.7
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    11. NM_001243515.2 → NP_001230444.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230444.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15) has two additional exons in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK290945, BU752915, DA720944, DA722064
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    12. NM_001243518.2 → NP_001230447.1  estrogen-related receptor gamma isoform 6

      See identical proteins and their annotated locations for NP_001230447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16) has an additional exon in the 5' region, which includes an AUG start codon, and an additional segment in the middle region, compared to variant 1. The resulting isoform (6) has a longer and distinct N-terminus and an additional internal segment, compared to isoform 1.
      Source sequence(s)
      AB020639, BC064700, BU752915
      Consensus CDS
      CCDS58061.1
      UniProtKB/TrEMBL
      C0SQ93
      Related
      ENSP00000355904.1, ENST00000366937.5
      Conserved Domains (2) summary
      cd06946
      Location:249 → 468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127 → 223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    13. NM_001243519.2 → NP_001230448.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_001230448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17) has an additional segment in the 5' region and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BC008218, BU752915, DA720944
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000375761.4, ENST00000391890.7
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    14. NM_001350122.2 → NP_001337051.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (18) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AC096634, AL603752, BU752915, CA397450, DA215341, DA293919, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    15. NM_001350123.2 → NP_001337052.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (19) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    16. NM_001350124.2 → NP_001337053.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (20) lacks the 5' exon but has four alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AL603752, BU752915, BX647076, CA397450, DA215341
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    17. NM_001350125.2 → NP_001337054.1  estrogen-related receptor gamma isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (21) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450, DA096417, DB220304
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    18. NM_001438.4 → NP_001429.2  estrogen-related receptor gamma isoform 1

      See identical proteins and their annotated locations for NP_001429.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AB020639, BU752915
      Consensus CDS
      CCDS41468.1
      UniProtKB/Swiss-Prot
      A8K4I0, A8K6I2, B3KY84, E9PGB7, F8W8J3, O75454, O96021, P62508, Q68DA0, Q6P274, Q6PK28, Q6TS38, Q9R1F3, Q9UNJ4
      UniProtKB/TrEMBL
      C0SQ93, F1D8R5
      Related
      ENSP00000386171.3, ENST00000408911.8
      Conserved Domains (2) summary
      cd06946
      Location:237 → 456
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:122 → 218
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    19. NM_206594.3 → NP_996317.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996317.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks the 5' exon but has three alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, BU752915, CA397450
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000355225.3, ENST00000361525.7
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    20. NM_206595.3 → NP_996318.1  estrogen-related receptor gamma isoform 2

      See identical proteins and their annotated locations for NP_996318.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks the 5' exon but has two alternate 5' exons and uses a downstream AUG start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1. Variants 2-4, 9-15, and 17-21 encode the same isoform.
      Source sequence(s)
      AB020639, AK291028, BU752915
      Consensus CDS
      CCDS1517.1
      UniProtKB/TrEMBL
      C0SQ93, F1D8R6
      Related
      ENSP00000352077.2, ENST00000359162.6
      Conserved Domains (2) summary
      cd06946
      Location:214 → 433
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      216503246..217137702 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017000625.2 → XP_016856114.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    2. XM_047449371.1 → XP_047305327.1  estrogen-related receptor gamma isoform X3

    3. XM_017000622.2 → XP_016856111.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    4. XM_047449402.1 → XP_047305358.1  estrogen-related receptor gamma isoform X8

      Related
      ENSP00000500992.1, ENST00000673908.1

    5. XM_017000637.2 → XP_016856126.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221 → 440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    6. XM_017000624.3 → XP_016856113.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    7. XM_011509265.4 → XP_011507567.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    8. XM_017000621.3 → XP_016856110.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    9. XM_047449398.1 → XP_047305354.1  estrogen-related receptor gamma isoform X8

    10. XM_047449392.1 → XP_047305348.1  estrogen-related receptor gamma isoform X7

    11. XM_047449368.1 → XP_047305324.1  estrogen-related receptor gamma isoform X3

    12. XM_047449351.1 → XP_047305307.1  estrogen-related receptor gamma isoform X3

    13. XM_017000634.3 → XP_016856123.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221 → 440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    14. XM_017000631.3 → XP_016856120.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221 → 440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    15. XM_047449391.1 → XP_047305347.1  estrogen-related receptor gamma isoform X7

    16. XM_047449362.1 → XP_047305318.1  estrogen-related receptor gamma isoform X3

    17. XM_047449396.1 → XP_047305352.1  estrogen-related receptor gamma isoform X8

    18. XM_047449395.1 → XP_047305351.1  estrogen-related receptor gamma isoform X8

    19. XM_047449389.1 → XP_047305345.1  estrogen-related receptor gamma isoform X5

    20. XM_047449344.1 → XP_047305300.1  estrogen-related receptor gamma isoform X3

    21. XM_047449397.1 → XP_047305353.1  estrogen-related receptor gamma isoform X8

    22. XM_017000632.3 → XP_016856121.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221 → 440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    23. XM_011509266.4 → XP_011507568.1  estrogen-related receptor gamma isoform X2

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249 → 468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    24. XM_047449307.1 → XP_047305263.1  estrogen-related receptor gamma isoform X1

    25. XM_017000636.3 → XP_016856125.1  estrogen-related receptor gamma isoform X8

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:221 → 440
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:99 → 195
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    26. XM_017000623.3 → XP_016856112.1  estrogen-related receptor gamma isoform X1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:256 → 475
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:134 → 230
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    27. XM_047449403.1 → XP_047305359.1  estrogen-related receptor gamma isoform X8

    28. XM_047449385.1 → XP_047305341.1  estrogen-related receptor gamma isoform X4

    29. XM_011509271.3 → XP_011507573.1  estrogen-related receptor gamma isoform X7

      See identical proteins and their annotated locations for XP_011507573.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:226 → 445
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:104 → 200
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    30. XM_047449390.1 → XP_047305346.1  estrogen-related receptor gamma isoform X6

    31. XM_011509269.3 → XP_011507571.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507571.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249 → 468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127 → 223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    32. XM_011509268.3 → XP_011507570.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507570.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249 → 468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127 → 223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    33. XM_011509267.1 → XP_011507569.1  estrogen-related receptor gamma isoform X3

      See identical proteins and their annotated locations for XP_011507569.1

      UniProtKB/TrEMBL
      C0SQ93
      Conserved Domains (2) summary
      cd06946
      Location:249 → 468
      NR_LBD_ERR; The ligand binding domain of estrogen receptor-related nuclear receptors
      cd07170
      Location:127 → 223
      NR_DBD_ERR; DNA-binding domain of estrogen related receptors (ERR) is composed of two C4-type zinc fingers

    34. XM_047449394.1 → XP_047305350.1  estrogen-related receptor gamma isoform X7

    35. XM_047449401.1 → XP_047305357.1  estrogen-related receptor gamma isoform X8

    36. XM_047449393.1 → XP_047305349.1  estrogen-related receptor gamma isoform X7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      215743580..216378774 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335068.1 → XP_054191043.1  estrogen-related receptor gamma isoform X1

    2. XM_054335071.1 → XP_054191046.1  estrogen-related receptor gamma isoform X3

    3. XM_054335065.1 → XP_054191040.1  estrogen-related receptor gamma isoform X1

    4. XM_054335064.1 → XP_054191039.1  estrogen-related receptor gamma isoform X1

    5. XM_054335063.1 → XP_054191038.1  estrogen-related receptor gamma isoform X1

    6. XM_054335091.1 → XP_054191066.1  estrogen-related receptor gamma isoform X8

    7. XM_054335088.1 → XP_054191063.1  estrogen-related receptor gamma isoform X8

    8. XM_054335067.1 → XP_054191042.1  estrogen-related receptor gamma isoform X1

    9. XM_054335085.1 → XP_054191060.1  estrogen-related receptor gamma isoform X8

    10. XM_054335086.1 → XP_054191061.1  estrogen-related receptor gamma isoform X8

    11. XM_054335080.1 → XP_054191055.1  estrogen-related receptor gamma isoform X8

    12. XM_054335083.1 → XP_054191058.1  estrogen-related receptor gamma isoform X8

    13. XM_054335084.1 → XP_054191059.1  estrogen-related receptor gamma isoform X8

    14. XM_054335069.1 → XP_054191044.1  estrogen-related receptor gamma isoform X2

    15. XM_054335087.1 → XP_054191062.1  estrogen-related receptor gamma isoform X8

    16. XM_054335066.1 → XP_054191041.1  estrogen-related receptor gamma isoform X1

    17. XM_054335089.1 → XP_054191064.1  estrogen-related receptor gamma isoform X8

    18. XM_054335092.1 → XP_054191067.1  estrogen-related receptor gamma isoform X8

    19. XM_054335074.1 → XP_054191049.1  estrogen-related receptor gamma isoform X4

    20. XM_054335078.1 → XP_054191053.1  estrogen-related receptor gamma isoform X7

    21. XM_054335076.1 → XP_054191051.1  estrogen-related receptor gamma isoform X6

    22. XM_054335073.1 → XP_054191048.1  estrogen-related receptor gamma isoform X3

    23. XM_054335072.1 → XP_054191047.1  estrogen-related receptor gamma isoform X3

    24. XM_054335070.1 → XP_054191045.1  estrogen-related receptor gamma isoform X3

    25. XM_054335082.1 → XP_054191057.1  estrogen-related receptor gamma isoform X8

    26. XM_054335081.1 → XP_054191056.1  estrogen-related receptor gamma isoform X8

    27. XM_054335075.1 → XP_054191050.1  estrogen-related receptor gamma isoform X5

    28. XM_054335079.1 → XP_054191054.1  estrogen-related receptor gamma isoform X7

    29. XM_054335090.1 → XP_054191065.1  estrogen-related receptor gamma isoform X8

    30. XM_054335077.1 → XP_054191052.1  estrogen-related receptor gamma isoform X7

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P62508.1 GenPept UniProtKB/Swiss-Prot:P62508

    Gene LinkOut

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