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    SRPK2 SRSF protein kinase 2 [ Homo sapiens (human) ]

    Gene ID: 6733, updated on 10-Dec-2024

    Summary

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    Official Symbol
    SRPK2provided by HGNC
    Official Full Name
    SRSF protein kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11306
    See related
    Ensembl:ENSG00000135250 MIM:602980; AllianceGenome:HGNC:11306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SFRSK2
    Summary
    Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including R-loop processing; peptidyl-serine phosphorylation; and regulation of viral genome replication. Located in chromatin; cytosol; and nuclear lumen. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in testis (RPKM 31.3), brain (RPKM 21.9) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See SRPK2 in Genome Data Viewer
    Location:
    7q22.3
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (105114740..105399357, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (106428390..106713586, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (104756821..105029838, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26452 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26453 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:104627453-104627954 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:104627955-104628454 Neighboring gene long intergenic non-protein coding RNA 1004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104652040-104652580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26454 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26457 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26456 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18512 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104653661-104654200 Neighboring gene KMT2E antisense RNA 1 Neighboring gene lysine methyltransferase 2E (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18514 Neighboring gene uncharacterized LOC124901717 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18515 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:104782308-104782484 Neighboring gene uncharacterized LOC124901718 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104868816-104869316 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:104885101-104885641 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26458 Neighboring gene ribosomal protein L36 pseudogene 12 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26460 Neighboring gene RWD domain containing 4 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:104981783-104982284 Neighboring gene RNA, U6 small nuclear 1322, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26461 Neighboring gene small integral membrane protein 12-like Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105017433-105018419 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18518 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18521 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18517 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18516 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:105044328-105044513 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26462 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:105107997-105108545 Neighboring gene pseudouridine synthase 7 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105160613-105161230 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:105161545-105162199 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:105163483-105163983 Neighboring gene ring finger protein 181 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53. Wang G, et al. FEBS J, 2019 May. PMID 30724469
    2. Dysregulation of splicing proteins in head and neck squamous cell carcinoma. Radhakrishnan A, et al. Cancer Biol Ther, 2016. PMID 26853621, Free PMC Article
    3. SRPK2 promotes the growth and migration of the colon cancer cells. Wang J, et al. Gene, 2016 Jul 15. PMID 27041240
    4. Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer. Zhuo YJ, et al. Biomed Pharmacother, 2018 Jun. PMID 29587239
    5. The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease? Yang Z, et al. Hepatology, 2023 Nov 1. PMID 37183907, Free PMC Article

    See all (133) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
      Title: SRPK2 Mediates HBV Core Protein Phosphorylation and Capsid Assembly via Docking Interaction.
    2. The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
      Title: The pre-mRNA alternative splicing regulated by SRPK2: A new player in alcohol-associated liver disease?
    3. Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
      Title: Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
    4. Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
      Title: Inhibition of Long Noncoding RNA Linc-Pint by Hepatitis C Virus in Infected Hepatocytes Enhances Lipogenesis.
    5. SRPK1/2 and PP1alpha exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
      Title: SRPK1/2 and PP1α exert opposite functions by modulating SRSF1-guided MKNK2 alternative splicing in colon adenocarcinoma.
    6. Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
      Title: Cooperation of SRPK2, Numb and p53 in the malignant biology and chemosensitivity of colorectal cancer.
    7. Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
      Title: Serine-Arginine Protein Kinase SRPK2 Modulates the Assembly of the Active Zone Scaffolding Protein CAST1/ERC2.
    8. SRPK2 expression was upregulated in pancreatic cancer tissues, positively correlated with stage, and associated with decreased overall survival in pancreatic cancer patients. In pancreatic cancer cells, SRPK2 overexpression promoted cell invasion and migration, and decreased chemosensitivity to gemcitabine or oxaliplatin. SRPK2 silencing decreased cell invasion and migration and increased chemosensitivity.
      Title: Serine/arginine protein-specific kinase 2 promotes the development and progression of pancreatic cancer by downregulating Numb and p53.
    9. The conserved SRPK-specific substrate-docking groove in SRPK2 impacts the binding and phosphorylation of both SR proteins, and the localization of SRSF3.
      Title: Distinct mechanisms govern the phosphorylation of different SR protein splicing factors.
    10. SRPK2 may play an important role in the progression and metastasis of prostate cancer.
      Title: Enhanced expression of SRPK2 contributes to aggressive progression and metastasis in prostate cancer.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.
    EBI GWAS Catalog
    Biological insights from 108 schizophrenia-associated genetic loci.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ36101

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 14-3-3 protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables 3-phosphoinositide-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables AMP-activated protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-dependent protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA binding HDA PubMed 
    enables Rho-dependent protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables eukaryotic translation initiation factor 2alpha kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AS121 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AT120 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2AXS139 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS14 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H2BS36 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S10 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S28 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3S57 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T11 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T3 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T45 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H3T6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables histone H4S1 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables magnesium ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables ribosomal protein S6 kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in R-loop processing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in RNA splicing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in innate immune response IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in intracellular signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear speck organization ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in peptidyl-serine phosphorylation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in positive regulation of cell cycle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of neuron apoptotic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in positive regulation of viral genome replication IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein phosphorylation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of mRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of mRNA splicing, via spliceosome TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in spliceosomal complex assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in spliceosomal complex assembly IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    SRSF protein kinase 2
    Names
    SFRS protein kinase 2
    SR protein kinase 2
    SR-protein-specific kinase 2
    serine kinase SRPK2
    serine/arginine-rich protein-specific kinase 2
    serine/arginine-rich splicing factor kinase 2
    serine/threonine-protein kinase SRPK2
    NP_001265202.1
    NP_001337667.1
    NP_001337668.1
    NP_001337669.1
    NP_001337670.1
    NP_001337671.1
    NP_001337672.1
    NP_001337673.1
    NP_001337674.1
    NP_001337675.1
    NP_872633.1
    NP_872634.1
    XP_006716161.1
    XP_011514838.1
    XP_011514840.1
    XP_016868050.2
    XP_024302661.1
    XP_024302662.1
    XP_024302663.1
    XP_047276728.1
    XP_047276729.1
    XP_047276730.1
    XP_047276731.1
    XP_047276732.1
    XP_054214855.1
    XP_054214856.1
    XP_054214857.1
    XP_054214858.1
    XP_054214859.1
    XP_054214860.1
    XP_054214861.1
    XP_054214862.1
    XP_054214863.1
    XP_054214864.1
    XP_054214865.1
    XP_054214866.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001278273.2 → NP_001265202.1  SRSF protein kinase 2 isoform b precursor

      See identical proteins and their annotated locations for NP_001265202.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      AC004884, AC005070, BC035214, BC068547, BU632662
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
      UniProtKB/TrEMBL
      H7C5L6
      Related
      ENSP00000419791.1, ENST00000489828.5
      Conserved Domains (2) summary
      cl21453
      Location:68 → 256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    2. NM_001350738.2 → NP_001337667.1  SRSF protein kinase 2 isoform b

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4), as well as variants 2 and 3, encodes isoform b.
      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (2) summary
      cl21453
      Location:68 → 256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. NM_001350739.2 → NP_001337668.1  SRSF protein kinase 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070
      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (3) summary
      cd14217
      Location:68 → 256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504 → 686
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    4. NM_001350740.2 → NP_001337669.1  SRSF protein kinase 2 isoform d

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) encodes the longest isoform (d).
      Source sequence(s)
      AC005070, AC073138
      Conserved Domains (3) summary
      cd14217
      Location:116 → 304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552 → 734
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389 → 431
      Na_Ca_ex; Sodium/calcium exchanger protein

    5. NM_001350741.2 → NP_001337670.1  SRSF protein kinase 2 isoform e

      Status: VALIDATED

      Source sequence(s)
      AC005070, AC073138
      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (2) summary
      cl21453
      Location:79 → 267
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:352 → 394
      Na_Ca_ex; Sodium/calcium exchanger protein

    6. NM_001350742.2 → NP_001337671.1  SRSF protein kinase 2 isoform f

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS94172.1
      UniProtKB/TrEMBL
      A0A994J591, H7C5L6
      Related
      ENSP00000516319.1, ENST00000482862.2
      Conserved Domains (3) summary
      cd14217
      Location:105 → 293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541 → 723
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378 → 420
      Na_Ca_ex; Sodium/calcium exchanger protein

    7. NM_001350743.2 → NP_001337672.1  SRSF protein kinase 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (9), as well as variant 10, encodes isoform g.
      Source sequence(s)
      AC004884, AC005070, AC073138
      Consensus CDS
      CCDS94171.1
      UniProtKB/TrEMBL
      C9J2M4, H7C5L6
      Related
      ENSP00000417357.2, ENST00000460391.6
      Conserved Domains (3) summary
      cd14217
      Location:68 → 256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504 → 717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    8. NM_001350744.2 → NP_001337673.1  SRSF protein kinase 2 isoform g

      Status: VALIDATED

      Description
      Transcript Variant: This variant (10), as well as variant 9, encodes isoform g.
      Source sequence(s)
      AC004884, AC005070
      Consensus CDS
      CCDS94171.1
      UniProtKB/TrEMBL
      C9J2M4, H7C5L6
      Conserved Domains (3) summary
      cd14217
      Location:68 → 256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504 → 717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    9. NM_001350745.2 → NP_001337674.1  SRSF protein kinase 2 isoform h

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070
      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (1) summary
      cl21453
      Location:70 → 640
      PKc_like; Protein Kinases, catalytic domain

    10. NM_001350746.2 → NP_001337675.1  SRSF protein kinase 2 isoform i

      Status: VALIDATED

      Source sequence(s)
      AC004884, AC005070, AC073138
      Conserved Domains (3) summary
      cd14217
      Location:105 → 293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:545 → 610
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378 → 420
      Na_Ca_ex; Sodium/calcium exchanger protein

    11. NM_182691.3 → NP_872633.1  SRSF protein kinase 2 isoform b precursor

      See identical proteins and their annotated locations for NP_872633.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has an alternate first exon compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a. Variants 2, 3, and 4 all encode the same isoform (b).
      Source sequence(s)
      BC035214, BU632662, CR746049, DA592321
      Consensus CDS
      CCDS5735.1
      UniProtKB/Swiss-Prot
      A8MVX2, O75220, O75221, P78362, Q6NUL0, Q6V1X2, Q8IYQ3
      UniProtKB/TrEMBL
      H7C5L6
      Related
      ENSP00000349863.3, ENST00000357311.7
      Conserved Domains (2) summary
      cl21453
      Location:68 → 256
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    12. NM_182692.3 → NP_872634.1  SRSF protein kinase 2 isoform a

      See identical proteins and their annotated locations for NP_872634.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      BC035214, BU632662, CR746049, HY031357
      Consensus CDS
      CCDS34724.1
      UniProtKB/TrEMBL
      H7C5L6
      Related
      ENSP00000377262.3, ENST00000393651.8
      Conserved Domains (2) summary
      smart00220
      Location:92 → 236
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cl21453
      Location:79 → 267
      PKc_like; Protein Kinases, catalytic domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      105114740..105399357 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516536.4 → XP_011514838.1  SRSF protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (2) summary
      cd14217
      Location:79 → 267
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:515 → 728
      PKc_like; Protein Kinases, catalytic domain

    2. XM_011516538.3 → XP_011514840.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_011514840.1

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6
      Conserved Domains (3) summary
      cd14217
      Location:68 → 256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504 → 717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    3. XM_024446895.2 → XP_024302663.1  SRSF protein kinase 2 isoform X4

      Conserved Domains (3) summary
      cd14217
      Location:116 → 304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552 → 734
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389 → 431
      Na_Ca_ex; Sodium/calcium exchanger protein

    4. XM_024446894.2 → XP_024302662.1  SRSF protein kinase 2 isoform X3

      Conserved Domains (3) summary
      cd14217
      Location:116 → 304
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:552 → 765
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:389 → 431
      Na_Ca_ex; Sodium/calcium exchanger protein

    5. XM_017012561.3 → XP_016868050.2  SRSF protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      H7C5L6
      Conserved Domains (3) summary
      cd14217
      Location:105 → 293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541 → 723
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378 → 420
      Na_Ca_ex; Sodium/calcium exchanger protein

    6. XM_024446893.2 → XP_024302661.1  SRSF protein kinase 2 isoform X1

      Conserved Domains (3) summary
      cd14217
      Location:105 → 293
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:541 → 754
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:378 → 420
      Na_Ca_ex; Sodium/calcium exchanger protein

    7. XM_047420772.1 → XP_047276728.1  SRSF protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6

    8. XM_047420776.1 → XP_047276732.1  SRSF protein kinase 2 isoform X9

    9. XM_047420773.1 → XP_047276729.1  SRSF protein kinase 2 isoform X7

      UniProtKB/TrEMBL
      H7C5L6

    10. XM_047420774.1 → XP_047276730.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      H7C5L6
      Related
      ENSP00000420208.2, ENST00000477925.6

    11. XM_006716098.4 → XP_006716161.1  SRSF protein kinase 2 isoform X6

      See identical proteins and their annotated locations for XP_006716161.1

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6
      Conserved Domains (3) summary
      cd14217
      Location:68 → 256
      STKc_SRPK2; Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2
      cl21453
      Location:504 → 717
      PKc_like; Protein Kinases, catalytic domain
      cl27511
      Location:341 → 383
      Na_Ca_ex; Sodium/calcium exchanger protein

    12. XM_047420775.1 → XP_047276731.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      H7C5L6

    RNA

    1. XR_007060151.1 RNA Sequence

    2. XR_007060150.1 RNA Sequence

    3. XR_007060147.1 RNA Sequence

    4. XR_001744862.3 RNA Sequence

    5. XR_007060153.1 RNA Sequence

    6. XR_007060148.1 RNA Sequence

    7. XR_007060149.1 RNA Sequence

    8. XR_001744863.3 RNA Sequence

    9. XR_001744861.3 RNA Sequence

    10. XR_007060152.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      106428390..106713586 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054358884.1 → XP_054214859.1  SRSF protein kinase 2 isoform X5

      UniProtKB/TrEMBL
      H7C5L6

    2. XM_054358887.1 → XP_054214862.1  SRSF protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6

    3. XM_054358883.1 → XP_054214858.1  SRSF protein kinase 2 isoform X4

    4. XM_054358882.1 → XP_054214857.1  SRSF protein kinase 2 isoform X3

    5. XM_054358881.1 → XP_054214856.1  SRSF protein kinase 2 isoform X2

      UniProtKB/TrEMBL
      H7C5L6

    6. XM_054358880.1 → XP_054214855.1  SRSF protein kinase 2 isoform X1

    7. XM_054358886.1 → XP_054214861.1  SRSF protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6

    8. XM_054358891.1 → XP_054214866.1  SRSF protein kinase 2 isoform X9

    9. XM_054358888.1 → XP_054214863.1  SRSF protein kinase 2 isoform X7

      UniProtKB/TrEMBL
      H7C5L6

    10. XM_054358889.1 → XP_054214864.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      H7C5L6

    11. XM_054358885.1 → XP_054214860.1  SRSF protein kinase 2 isoform X6

      UniProtKB/TrEMBL
      C9J2M4, H7C5L6

    12. XM_054358890.1 → XP_054214865.1  SRSF protein kinase 2 isoform X8

      UniProtKB/TrEMBL
      H7C5L6

    RNA

    1. XR_008487747.1 RNA Sequence

    2. XR_008487746.1 RNA Sequence

    3. XR_008487742.1 RNA Sequence

    4. XR_008487741.1 RNA Sequence

    5. XR_008487749.1 RNA Sequence

    6. XR_008487744.1 RNA Sequence

    7. XR_008487745.1 RNA Sequence

    8. XR_008487743.1 RNA Sequence

    9. XR_008487740.1 RNA Sequence

    10. XR_008487748.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P78362.3 GenPept UniProtKB/Swiss-Prot:P78362

    Gene LinkOut

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