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    CPN2 carboxypeptidase N subunit 2 [ Homo sapiens (human) ]

    Gene ID: 1370, updated on 2-Nov-2024

    Summary

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    Official Symbol
    CPN2provided by HGNC
    Official Full Name
    carboxypeptidase N subunit 2provided by HGNC
    Primary source
    HGNC:HGNC:2313
    See related
    Ensembl:ENSG00000178772 MIM:603104; AllianceGenome:HGNC:2313
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ACBP
    Summary
    Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Restricted expression toward liver (RPKM 60.4) See more
    Orthologs
    mouse all
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    Genomic context

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    See CPN2 in Genome Data Viewer
    Location:
    3q29
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (194339768..194351328, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (197038329..197049487, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (194060497..194072057, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:193994438-193995637 Neighboring gene long intergenic non-protein coding RNA 2048 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194000115-194000616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194000617-194001116 Neighboring gene long intergenic non-protein coding RNA 887 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21018 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21020 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194033347-194033847 Neighboring gene Sharpr-MPRA regulatory region 2488 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:194039992-194041191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194057362-194058242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:194059168-194059834 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194071533-194072382 Neighboring gene leucine rich repeat containing 15 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:194089931-194090895 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15021 Neighboring gene glycoprotein V platelet

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. The deduced protein sequence of the human carboxypeptidase N high molecular weight subunit reveals the presence of leucine-rich tandem repeats. Tan F, et al. J Biol Chem, 1990 Jan 5. PMID 2378615
    2. Role of Carboxypeptidase N Invasion and Migration in Breast Cancer. Cui R, et al. Anticancer Agents Med Chem, 2016. PMID 26860443
    3. Amino acid sequence of the N-terminus and selected tryptic peptides of the active subunit of human plasma carboxypeptidase N: comparison with other carboxypeptidases. Skidgel RA, et al. Biochem Biophys Res Commun, 1988 Aug 15. PMID 3408501
    4. Carboxypeptidase N: a pleiotropic regulator of inflammation. Matthews KW, et al. Mol Immunol, 2004 Jan. PMID 14687935
    5. Chromosomal localization of the genes for human carboxypeptidase D (CPD) and the active 50-kilodalton subunit of human carboxypeptidase N (CPN1). Riley DA, et al. Genomics, 1998 May 15. PMID 9628828

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of carboxypeptidase N, polypeptide 2 (CPN2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme regulator activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein stabilization NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in blood microparticle HDA PubMed 
    located_in extracellular exosome HDA PubMed 
    is_active_in extracellular matrix IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    carboxypeptidase N subunit 2
    Names
    carboxypeptidase N 83 kDa chain
    carboxypeptidase N large subunit
    carboxypeptidase N regulatory subunit
    carboxypeptidase N, polypeptide 2, 83kD
    NP_001073982.3
    NP_001278917.1
    XP_005269337.1
    XP_054201277.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001080513.4 → NP_001073982.3  carboxypeptidase N subunit 2 precursor

      See identical proteins and their annotated locations for NP_001073982.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AC174158
      Consensus CDS
      CCDS33920.1
      UniProtKB/Swiss-Prot
      B2RPE7, P22792, Q86SU4, Q8N5V4
      Related
      ENSP00000319464.3, ENST00000323830.4
      Conserved Domains (6) summary
      smart00013
      Location:21 → 53
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:395 → 446
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:149 → 356
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:387 → 399
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:123 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:294 → 349
      LRR_8; Leucine rich repeat

    2. NM_001291988.2 → NP_001278917.1  carboxypeptidase N subunit 2 precursor

      See identical proteins and their annotated locations for NP_001278917.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR. Variants 1 and 3 encode the same protein.
      Source sequence(s)
      AC174158
      Consensus CDS
      CCDS33920.1
      UniProtKB/Swiss-Prot
      B2RPE7, P22792, Q86SU4, Q8N5V4
      Related
      ENSP00000402232.1, ENST00000429275.1
      Conserved Domains (6) summary
      smart00013
      Location:21 → 53
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:395 → 446
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:149 → 356
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:387 → 399
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:123 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:294 → 349
      LRR_8; Leucine rich repeat

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      194339768..194351328 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005269280.5 → XP_005269337.1  carboxypeptidase N subunit 2 isoform X1

      See identical proteins and their annotated locations for XP_005269337.1

      UniProtKB/Swiss-Prot
      B2RPE7, P22792, Q86SU4, Q8N5V4
      Conserved Domains (6) summary
      smart00013
      Location:21 → 53
      LRRNT; Leucine rich repeat N-terminal domain
      smart00082
      Location:395 → 446
      LRRCT; Leucine rich repeat C-terminal domain
      cd00116
      Location:149 → 356
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      sd00031
      Location:387 → 399
      LRR_1; leucine-rich repeat [structural motif]
      sd00033
      Location:123 → 146
      LRR_RI; leucine-rich repeat [structural motif]
      pfam13855
      Location:294 → 349
      LRR_8; Leucine rich repeat

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      197038329..197049487 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345302.1 → XP_054201277.1  carboxypeptidase N subunit 2 isoform X1

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001309.1: Suppressed sequence

      Description
      NM_001309.1: This RefSeq was temporarily suppressed because currently there is not sufficient data to support this transcript.
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P22792.3 GenPept UniProtKB/Swiss-Prot:P22792

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