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    IL20 interleukin 20 [ Homo sapiens (human) ]

    Gene ID: 50604, updated on 10-Dec-2024

    Summary

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    Official Symbol
    IL20provided by HGNC
    Official Full Name
    interleukin 20provided by HGNC
    Primary source
    HGNC:HGNC:6002
    See related
    Ensembl:ENSG00000162891 MIM:605619; AllianceGenome:HGNC:6002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-20; IL10D; ZCYTO10
    Summary
    The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    mouse all
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    Genomic context

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    See IL20 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206863565..206869223)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206127873..206133530)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207036910..207042568)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene interleukin 10 Neighboring gene interleukin 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene interleukin 24 Neighboring gene Fc mu receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Interleukin-20 is triggered by TLR ligands and associates with disease activity in patients with rheumatoid arthritis. Šenolt L, et al. Cytokine, 2017 Sep. PMID 28662439
    2. Decreased interleukin-20 level in patients with systemic sclerosis: are they related with angiogenesis? Aydoğdu E, et al. Clin Rheumatol, 2013 Nov. PMID 23812620
    3. IL-20 may contribute to the pathogenesis of human intervertebral disc herniation. Huang KY, et al. Spine (Phila Pa 1976), 2008 Sep 1. PMID 18758357
    4. Decreased interleukin-20 expression in scleroderma skin contributes to cutaneous fibrosis. Kudo H, et al. Arthritis Rheumatol, 2014 Jun. PMID 24470401, Free PMC Article
    5. Interleukin 20 protein locates to distinct mononuclear cells in psoriatic skin. Bech R, et al. Exp Dermatol, 2014 May. PMID 24628979

    See all (88) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The effect of interleukin-20 on periodontal tissue destruction in individuals with periodontitis.
      Title: The effect of interleukin-20 on periodontal tissue destruction in individuals with periodontitis.
    2. IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
      Title: IL-20 controls resolution of experimental colitis by regulating epithelial IFN/STAT2 signalling.
    3. IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
      Title: IL-20 subfamily cytokines impair the oesophageal epithelial barrier by diminishing filaggrin in eosinophilic oesophagitis.
    4. Overexpression of interleukin-20 correlates with favourable prognosis in diffuse large B-cell lymphoma.
      Title: Overexpression of interleukin-20 correlates with favourable prognosis in diffuse large B-cell lymphoma.
    5. gamma-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro.
      Title: γ-Secretase inhibitors suppress IL-20-mediated osteoclastogenesis via Notch signalling and are affected by Notch2 in vitro.
    6. Interleukin-20 is involved in dry eye disease and is a potential therapeutic target.
      Title: Interleukin-20 is involved in dry eye disease and is a potential therapeutic target.
    7. IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
      Title: IL-20 promotes cutaneous inflammation and peripheral itch sensation in atopic dermatitis.
    8. Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction.
      Title: Increased expression of IL-20 is associated with ischemic cardiomyopathy and acute myocardial infarction.
    9. IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
      Title: IL-20 is involved in obesity by modulation of adipogenesis and macrophage dysregulation.
    10. The expression of interleukin 20 increases in plasma and aortic tissues from patients with acute aortic dissection.
      Title: The expression of interleukin 20 increases in plasma and aortic tissues from patients with acute aortic dissection.
    Submit: New GeneRIF Correction See all GeneRIFs (70)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    HIV-1 interactions

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    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC96907

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables interleukin-20 receptor binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables interleukin-22 receptor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of epidermal cell differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of keratinocyte differentiation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of osteoclast differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of tyrosine phosphorylation of STAT protein TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in regulation of inflammatory response TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    interleukin-20
    Names
    cytokine Zcyto10
    four alpha helix cytokine

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385165.1 → NP_001372094.1  interleukin-20 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS91155.1
      Related
      ENSP00000375796.2, ENST00000391930.3

    2. NM_001385166.1 → NP_001372095.1  interleukin-20 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Conserved Domains (1) summary
      cl02501
      Location:39 → 173
      IL10; Interleukin 10

    3. NM_001385167.1 → NP_001372096.1  interleukin-20 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Conserved Domains (1) summary
      cl02501
      Location:39 → 173
      IL10; Interleukin 10

    4. NM_018724.4 → NP_061194.2  interleukin-20 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061194.2

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Related
      ENSP00000356065.1, ENST00000367098.6
      Conserved Domains (1) summary
      cl02501
      Location:39 → 173
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206863565..206869223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206127873..206133530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9NYY1.2 GenPept UniProtKB/Swiss-Prot:Q9NYY1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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