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    IL20 interleukin 20 [ Homo sapiens (human) ]

    Gene ID: 50604, updated on 10-Dec-2024

    Summary

    Official Symbol
    IL20provided by HGNC
    Official Full Name
    interleukin 20provided by HGNC
    Primary source
    HGNC:HGNC:6002
    See related
    Ensembl:ENSG00000162891 MIM:605619; AllianceGenome:HGNC:6002
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IL-20; IL10D; ZCYTO10
    Summary
    The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL20 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (206863565..206869223)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (206127873..206133530)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (207036910..207042568)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2418 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2419 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory element GRCh37_chr1:206945468-206946089 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2420 Neighboring gene interleukin 10 Neighboring gene interleukin 19 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2422 Neighboring gene CRISPRi-FlowFISH-validated IL10 regulatory elements GRCh37_chr1:206966528-206967028 and GRCh37_chr1:206966531-206967031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2424 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2425 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1767 Neighboring gene uncharacterized LOC105372878 Neighboring gene uncharacterized LOC105372879 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:207063449-207064648 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2426 Neighboring gene interleukin 24 Neighboring gene Fc mu receptor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat IL-20 is upregulated by HIV-1 Tat treatment in human epithelial cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC96907

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables interleukin-20 receptor binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables interleukin-22 receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    interleukin-20
    Names
    cytokine Zcyto10
    four alpha helix cytokine

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001385165.1NP_001372094.1  interleukin-20 isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS91155.1
      Related
      ENSP00000375796.2, ENST00000391930.3
    2. NM_001385166.1NP_001372095.1  interleukin-20 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Conserved Domains (1) summary
      cl02501
      Location:39173
      IL10; Interleukin 10
    3. NM_001385167.1NP_001372096.1  interleukin-20 isoform 1 precursor

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Conserved Domains (1) summary
      cl02501
      Location:39173
      IL10; Interleukin 10
    4. NM_018724.4NP_061194.2  interleukin-20 isoform 1 precursor

      See identical proteins and their annotated locations for NP_061194.2

      Status: REVIEWED

      Source sequence(s)
      AC098935
      Consensus CDS
      CCDS1470.1
      UniProtKB/Swiss-Prot
      Q17RB3, Q2THG6, Q96QZ6, Q9NYY1
      UniProtKB/TrEMBL
      A0A7R8C4W0
      Related
      ENSP00000356065.1, ENST00000367098.6
      Conserved Domains (1) summary
      cl02501
      Location:39173
      IL10; Interleukin 10

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      206863565..206869223
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      206127873..206133530
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)