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    TPK1 thiamin pyrophosphokinase 1 [ Homo sapiens (human) ]

    Gene ID: 27010, updated on 2-Nov-2024

    Summary

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    Official Symbol
    TPK1provided by HGNC
    Official Full Name
    thiamin pyrophosphokinase 1provided by HGNC
    Primary source
    HGNC:HGNC:17358
    See related
    Ensembl:ENSG00000196511 MIM:606370; AllianceGenome:HGNC:17358
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PP20; HTPK1; THMD5
    Summary
    The protein encoded by this gene functions as a homodimer and catalyzes the conversion of thiamine to thiamine pyrophosphate, a cofactor for some enzymes of the glycolytic and energy production pathways. Defects in this gene are a cause of thiamine metabolism dysfunction syndrome-5. [provided by RefSeq, Apr 2017]
    Expression
    Ubiquitous expression in duodenum (RPKM 1.3), testis (RPKM 0.7) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See TPK1 in Genome Data Viewer
    Location:
    7q35
    Exon count:
    26
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (144451941..144836437, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145632112..146017232, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (144149034..144533146, complement)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene RNA, U6atac small nuclear 40, pseudogene Neighboring gene peptidylprolyl isomerase A pseudogene 83 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144172657-144173158 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18729 Neighboring gene Sharpr-MPRA regulatory region 13519 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18730 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr7:144231635-144232508 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144262663-144263224 Neighboring gene NANOG hESC enhancer GRCh37_chr7:144316313-144316842 Neighboring gene eukaryotic translation elongation factor 1 alpha 1 pseudogene 10 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18731 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26797 Neighboring gene RN7SK pseudogene 174 Neighboring gene MPRA-validated peak6812 silencer Neighboring gene uncharacterized LOC105375552

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer. Hong JY, et al. Pathol Res Pract, 2020 Mar. PMID 31964553
    2. Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway. Mayr JA, et al. Am J Hum Genet, 2011 Dec 9. PMID 22152682, Free PMC Article
    3. Expanding the clinical and molecular spectrum of thiamine pyrophosphokinase deficiency: a treatable neurological disorder caused by TPK1 mutations. Banka S, et al. Mol Genet Metab, 2014 Dec. PMID 25458521
    4. TPK1 mutation induced childhood onset idiopathic generalized dystonia: Report of a rare mutation and effect of deep brain stimulation. Mahajan A, et al. J Neurol Sci, 2017 May 15. PMID 28431625
    5. Radiometric assay for thiamine pyrophosphokinase activity in human leukocytes. Iwashima A, et al. Acta Vitaminol Enzymol, 1983. PMID 6303095

    See all (42) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
      Title: The conserved Tpk1 regulates non-homologous end joining double-strand break repair by phosphorylation of Nej1, a homolog of the human XLF.
    2. Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype.
      Title: Movement disorders associated with thiamine pyrophosphokinase deficiency: Intrafamilial variability in the phenotype.
    3. Whole Exome Sequencing Identifies a Novel Mutation of TPK1 in a Chinese Family with Recurrent Ataxia.
      Title: Whole Exome Sequencing Identifies a Novel Mutation of TPK1 in a Chinese Family with Recurrent Ataxia.
    4. TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer.
      Title: TPK1 as a predictive marker for the anti-tumour effects of simvastatin in gastric cancer.
    5. any disease mutants are directly or indirectly involved in thiamine binding. Thus, our study provided a novel rationale for thiamine supplementation, so far the major therapeutic intervention in TPK deficiency.
      Title: Reduced thiamine binding is a novel mechanism for TPK deficiency disorder.
    6. These findings demonstrate that the genes involved in dictating thiamine homeostasis, such as SLC19A2, SLC25A19 and TPK-1, were significantly up-regulated in clinical tissues and breast cancer cell lines.
      Title: Up-regulation of vitamin B1 homeostasis genes in breast cancer.
    7. Mutation analysis of TPK1 uncovered three missense, one splice-site, and one frameshift mutation resulting in decreased TPK protein levels
      Title: Thiamine pyrophosphokinase deficiency in encephalopathic children with defects in the pyruvate oxidation pathway.
    8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
      Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
    9. Observational study of gene-disease association. (HuGE Navigator)
      Title: Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight.
    10. Genomic variations in either the fetal or maternal TPK1 gene could contribute to variability of birth weight in normal humans.
      Title: Three common intronic variants in the maternal and fetal thiamine pyrophosphokinase gene (TPK1) are associated with birth weight.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Childhood encephalopathy due to thiamine pyrophosphokinase deficiency
    MedGen: C3280866 OMIM: 614458 GeneReviews: Not available
    		Compare labs

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    HIV-1 interactions

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    Replication interactions

    Interaction Pubs
    Knockdown of thiamin pyrophosphokinase 1 (TPK1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Vif vif HIV-1 Vif upregulates the expression of thiamin pyrophosphokinase 1 (TPK1) in Vif-expression T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables UTP thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables thiamine binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables thiamine diphosphokinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables thiamine diphosphokinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in phosphorylation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of acetyl-CoA biosynthetic process from pyruvate IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in thiamine diphosphate biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in thiamine diphosphate biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thiamine metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    thiamine pyrophosphokinase 1
    Names
    placental protein 20
    thiamine diphosphokinase
    thiamine kinase
    NP_001035947.1
    NP_001337808.1
    NP_001337809.1
    NP_001337810.1
    NP_001337811.1
    NP_001337812.1
    NP_001337813.1
    NP_001337814.1
    NP_001337815.1
    NP_001337816.1
    NP_001337818.1
    NP_001337822.1
    NP_001337823.1
    NP_001337824.1
    NP_071890.2
    XP_005250027.1
    XP_011514333.1
    XP_011514334.1
    XP_011514335.1
    XP_011514336.1
    XP_011514339.1
    XP_011514341.1
    XP_011514342.1
    XP_011514345.1
    XP_011514348.1
    XP_011514349.1
    XP_011514350.1
    XP_016867458.1
    XP_016867459.1
    XP_016867460.1
    XP_016867461.1
    XP_016867469.1
    XP_016867470.1
    XP_024302485.1
    XP_047276148.1
    XP_047276150.1
    XP_047276151.1
    XP_047276152.1
    XP_047276153.1
    XP_047276154.1
    XP_047276155.1
    XP_054213854.1
    XP_054213855.1
    XP_054213856.1
    XP_054213857.1
    XP_054213858.1
    XP_054213859.1
    XP_054213860.1
    XP_054213861.1
    XP_054213862.1
    XP_054213863.1
    XP_054213864.1
    XP_054213865.1
    XP_054213866.1
    XP_054213867.1
    XP_054213868.1
    XP_054213869.1
    XP_054213870.1
    XP_054213871.1
    XP_054213872.1
    XP_054213873.1
    XP_054213874.1
    XP_054213875.1
    XP_054213876.1
    XP_054213877.1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032112.2 RefSeqGene

      Range
      5001..389113
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001042482.2 → NP_001035947.1  thiamine pyrophosphokinase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon, compared to variant 1, resulting in a shorter protein (isoform b), compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC004534, BC040555, BI770816, BX446289, DA135998
      Consensus CDS
      CCDS55178.1
      UniProtKB/TrEMBL
      F5GZG6
      Related
      ENSP00000367339.3, ENST00000378099.7
      Conserved Domains (1) summary
      cl27179
      Location:21 → 192
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    2. NM_001350879.1 → NP_001337808.1  thiamine pyrophosphokinase 1 isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3), as well as variant 1, encodes the longest isoform (a).
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Consensus CDS
      CCDS5888.1
      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0
      Conserved Domains (1) summary
      PLN02714
      Location:21 → 241
      PLN02714; thiamin pyrophosphokinase

    3. NM_001350880.1 → NP_001337809.1  thiamine pyrophosphokinase 1 isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4), as well as variant 2, encodes isoform b. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Consensus CDS
      CCDS55178.1
      UniProtKB/TrEMBL
      F5GZG6
      Conserved Domains (1) summary
      cl27179
      Location:21 → 192
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    4. NM_001350881.1 → NP_001337810.1  thiamine pyrophosphokinase 1 isoform c

      Status: REVIEWED

      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      cl27179
      Location:21 → 204
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    5. NM_001350882.1 → NP_001337811.1  thiamine pyrophosphokinase 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6), as well as variants 7 and 8, encodes isoform d.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      cl27179
      Location:58 → 236
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    6. NM_001350883.1 → NP_001337812.1  thiamine pyrophosphokinase 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7), as well as variants 6 and 8, encodes isoform d.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      cl27179
      Location:58 → 236
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    7. NM_001350884.2 → NP_001337813.1  thiamine pyrophosphokinase 1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 6 and 7, encodes isoform d.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864
      Conserved Domains (1) summary
      cl27179
      Location:58 → 236
      TPK_B1_binding; Thiamin pyrophosphokinase, vitamin B1 binding domain

    8. NM_001350885.1 → NP_001337814.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 10, 11, 12, 13, and 14, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    9. NM_001350886.1 → NP_001337815.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variants 9, 11, 12, 13, and 14, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    10. NM_001350887.1 → NP_001337816.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 9, 10, 12, 13, and 14, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    11. NM_001350889.1 → NP_001337818.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 9, 10, 11, 13, and 14, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    12. NM_001350893.1 → NP_001337822.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 9, 10, 11, 12, and 14, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    13. NM_001350894.1 → NP_001337823.1  thiamine pyrophosphokinase 1 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 9, 10, 11, 12, and 13, encodes isoform e.
      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    14. NM_001350895.1 → NP_001337824.1  thiamine pyrophosphokinase 1 isoform f

      Status: REVIEWED

      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384
      UniProtKB/TrEMBL
      B3KRJ6
      Conserved Domains (1) summary
      PLN02714
      Location:5 → 124
      PLN02714; thiamin pyrophosphokinase

    15. NM_022445.4 → NP_071890.2  thiamine pyrophosphokinase 1 isoform a

      See identical proteins and their annotated locations for NP_071890.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AF297710, BC040555, DA135998
      Consensus CDS
      CCDS5888.1
      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0
      Related
      ENSP00000353165.3, ENST00000360057.7
      Conserved Domains (1) summary
      PLN02714
      Location:21 → 241
      PLN02714; thiamin pyrophosphokinase

    RNA

    1. NR_146934.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384

    2. NR_146935.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864, AC074384

    3. NR_146936.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC004534, AC004743, AC004833, AC004864
      Related
      ENST00000482940.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      144451941..144836437 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005249970.2 → XP_005250027.1  thiamine pyrophosphokinase 1 isoform X1

      See identical proteins and their annotated locations for XP_005250027.1

      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0
      Conserved Domains (1) summary
      PLN02714
      Location:21 → 241
      PLN02714; thiamin pyrophosphokinase

    2. XM_047420194.1 → XP_047276150.1  thiamine pyrophosphokinase 1 isoform X2

      UniProtKB/TrEMBL
      F5GZG6

    3. XM_011516033.3 → XP_011514335.1  thiamine pyrophosphokinase 1 isoform X6

      See identical proteins and their annotated locations for XP_011514335.1

      Conserved Domains (2) summary
      cd07995
      Location:20 → 265
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:21 → 267
      PLN02714; thiamin pyrophosphokinase

    4. XM_047420195.1 → XP_047276151.1  thiamine pyrophosphokinase 1 isoform X2

      UniProtKB/TrEMBL
      F5GZG6

    5. XM_047420192.1 → XP_047276148.1  thiamine pyrophosphokinase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0

    6. XM_047420199.1 → XP_047276155.1  thiamine pyrophosphokinase 1 isoform X5

    7. XM_011516034.3 → XP_011514336.1  thiamine pyrophosphokinase 1 isoform X6

      See identical proteins and their annotated locations for XP_011514336.1

      Conserved Domains (2) summary
      cd07995
      Location:20 → 265
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:21 → 267
      PLN02714; thiamin pyrophosphokinase

    8. XM_047420197.1 → XP_047276153.1  thiamine pyrophosphokinase 1 isoform X5

    9. XM_011516043.2 → XP_011514345.1  thiamine pyrophosphokinase 1 isoform X12

      Conserved Domains (2) summary
      cd07995
      Location:20 → 216
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:21 → 218
      PLN02714; thiamin pyrophosphokinase

    10. XM_011516031.2 → XP_011514333.1  thiamine pyrophosphokinase 1 isoform X6

      See identical proteins and their annotated locations for XP_011514333.1

      Conserved Domains (2) summary
      cd07995
      Location:20 → 265
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:21 → 267
      PLN02714; thiamin pyrophosphokinase

    11. XM_011516032.3 → XP_011514334.1  thiamine pyrophosphokinase 1 isoform X6

      See identical proteins and their annotated locations for XP_011514334.1

      Conserved Domains (2) summary
      cd07995
      Location:20 → 265
      TPK; Thiamine pyrophosphokinase
      PLN02714
      Location:21 → 267
      PLN02714; thiamin pyrophosphokinase

    12. XM_047420198.1 → XP_047276154.1  thiamine pyrophosphokinase 1 isoform X5

    13. XM_024446717.2 → XP_024302485.1  thiamine pyrophosphokinase 1 isoform X5

      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    14. XM_017011970.1 → XP_016867459.1  thiamine pyrophosphokinase 1 isoform X8

      Conserved Domains (2) summary
      cd07995
      Location:58 → 260
      TPK; Thiamine pyrophosphokinase
      TIGR01378
      Location:19 → 260
      thi_PPkinase; thiamine pyrophosphokinase

    15. XM_047420196.1 → XP_047276152.1  thiamine pyrophosphokinase 1 isoform X3

      UniProtKB/TrEMBL
      Q6ZQX6
      Related
      ENSP00000438813.2, ENST00000538212.6

    16. XM_011516037.3 → XP_011514339.1  thiamine pyrophosphokinase 1 isoform X8

      See identical proteins and their annotated locations for XP_011514339.1

      Conserved Domains (2) summary
      cd07995
      Location:58 → 260
      TPK; Thiamine pyrophosphokinase
      TIGR01378
      Location:19 → 260
      thi_PPkinase; thiamine pyrophosphokinase

    17. XM_011516039.3 → XP_011514341.1  thiamine pyrophosphokinase 1 isoform X10

      Conserved Domains (1) summary
      cd07995
      Location:33 → 239
      TPK; Thiamine pyrophosphokinase

    18. XM_017011971.2 → XP_016867460.1  thiamine pyrophosphokinase 1 isoform X8

      Conserved Domains (2) summary
      cd07995
      Location:58 → 260
      TPK; Thiamine pyrophosphokinase
      TIGR01378
      Location:19 → 260
      thi_PPkinase; thiamine pyrophosphokinase

    19. XM_011516047.3 → XP_011514349.1  thiamine pyrophosphokinase 1 isoform X5

      See identical proteins and their annotated locations for XP_011514349.1

      UniProtKB/Swiss-Prot
      Q9H3S4
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    20. XM_011516048.1 → XP_011514350.1  thiamine pyrophosphokinase 1 isoform X5

      See identical proteins and their annotated locations for XP_011514350.1

      UniProtKB/Swiss-Prot
      Q9H3S4
      Conserved Domains (1) summary
      PLN02714
      Location:16 → 135
      PLN02714; thiamin pyrophosphokinase

    21. XM_017011980.3 → XP_016867469.1  thiamine pyrophosphokinase 1 isoform X4

      Conserved Domains (1) summary
      cd07995
      Location:2 → 159
      TPK; Thiamine pyrophosphokinase

    22. XM_017011981.3 → XP_016867470.1  thiamine pyrophosphokinase 1 isoform X4

      Conserved Domains (1) summary
      cd07995
      Location:2 → 159
      TPK; Thiamine pyrophosphokinase

    23. XM_017011972.2 → XP_016867461.1  thiamine pyrophosphokinase 1 isoform X9

    24. XM_017011969.2 → XP_016867458.1  thiamine pyrophosphokinase 1 isoform X7

    25. XM_011516040.3 → XP_011514342.1  thiamine pyrophosphokinase 1 isoform X11

      Conserved Domains (1) summary
      cd07995
      Location:20 → 230
      TPK; Thiamine pyrophosphokinase

    26. XM_011516046.2 → XP_011514348.1  thiamine pyrophosphokinase 1 isoform X13

      UniProtKB/TrEMBL
      F8WCM7
      Related
      ENSP00000367338.4, ENST00000378098.8
      Conserved Domains (1) summary
      pfam04263
      Location:30 → 137
      TPK_catalytic; Thiamin pyrophosphokinase, catalytic domain

    RNA

    1. XR_001744630.2 RNA Sequence

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_018654715.1 Reference GRCh38.p14 PATCHES

      Range
      501398..674070 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      145632112..146017232 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357886.1 → XP_054213861.1  thiamine pyrophosphokinase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0

    2. XM_054357892.1 → XP_054213867.1  thiamine pyrophosphokinase 1 isoform X2

      UniProtKB/TrEMBL
      F5GZG6

    3. XM_054357890.1 → XP_054213865.1  thiamine pyrophosphokinase 1 isoform X18

    4. XM_054357891.1 → XP_054213866.1  thiamine pyrophosphokinase 1 isoform X19

    5. XM_054357879.1 → XP_054213854.1  thiamine pyrophosphokinase 1 isoform X14

    6. XM_054357893.1 → XP_054213868.1  thiamine pyrophosphokinase 1 isoform X2

      UniProtKB/TrEMBL
      F5GZG6

    7. XM_054357887.1 → XP_054213862.1  thiamine pyrophosphokinase 1 isoform X1

      UniProtKB/Swiss-Prot
      A8K0T7, D3DWG0, I6L9B8, Q6NUR5, Q9H3S4, Q9H602
      UniProtKB/TrEMBL
      A0A090N8Y0

    8. XM_054357898.1 → XP_054213873.1  thiamine pyrophosphokinase 1 isoform X5

    9. XM_054357880.1 → XP_054213855.1  thiamine pyrophosphokinase 1 isoform X14

    10. XM_054357899.1 → XP_054213874.1  thiamine pyrophosphokinase 1 isoform X5

    11. XM_054357881.1 → XP_054213856.1  thiamine pyrophosphokinase 1 isoform X14

    12. XM_054357882.1 → XP_054213857.1  thiamine pyrophosphokinase 1 isoform X14

    13. XM_054357897.1 → XP_054213872.1  thiamine pyrophosphokinase 1 isoform X5

    14. XM_054357902.1 → XP_054213877.1  thiamine pyrophosphokinase 1 isoform X5

    15. XM_054357883.1 → XP_054213858.1  thiamine pyrophosphokinase 1 isoform X15

    16. XM_054357894.1 → XP_054213869.1  thiamine pyrophosphokinase 1 isoform X3

      UniProtKB/TrEMBL
      Q6ZQX6

    17. XM_054357884.1 → XP_054213859.1  thiamine pyrophosphokinase 1 isoform X15

    18. XM_054357888.1 → XP_054213863.1  thiamine pyrophosphokinase 1 isoform X16

    19. XM_054357885.1 → XP_054213860.1  thiamine pyrophosphokinase 1 isoform X15

    20. XM_054357900.1 → XP_054213875.1  thiamine pyrophosphokinase 1 isoform X5

    21. XM_054357901.1 → XP_054213876.1  thiamine pyrophosphokinase 1 isoform X5

    22. XM_054357895.1 → XP_054213870.1  thiamine pyrophosphokinase 1 isoform X4

    23. XM_054357889.1 → XP_054213864.1  thiamine pyrophosphokinase 1 isoform X17

    24. XM_054357896.1 → XP_054213871.1  thiamine pyrophosphokinase 1 isoform X20

    RNA

    1. XR_008487563.1 RNA Sequence

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9H3S4.1 GenPept UniProtKB/Swiss-Prot:Q9H3S4

    Gene LinkOut

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