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    ZNF281 zinc finger protein 281 [ Homo sapiens (human) ]

    Gene ID: 23528, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZNF281provided by HGNC
    Official Full Name
    zinc finger protein 281provided by HGNC
    Primary source
    HGNC:HGNC:13075
    See related
    Ensembl:ENSG00000162702 MIM:618703; AllianceGenome:HGNC:13075
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GZP1; ZBP99; ZBP-99; ZNP-99
    Summary
    Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of gene expression; negative regulation of transcription by RNA polymerase II; and positive regulation of DNA-templated transcription. Located in nucleoplasm. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in bone marrow (RPKM 10.1), appendix (RPKM 5.7) and 25 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See ZNF281 in Genome Data Viewer
    Location:
    1q32.1
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (200404951..200410036, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (199661900..199740523, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (200374079..200379164, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124904479 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1669 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:200271617-200271834 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200321702-200322202 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200322203-200322703 Neighboring gene long intergenic non-protein coding RNA 862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200324513-200325012 Neighboring gene Sharpr-MPRA regulatory regions 7059 and 708 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200341274-200341804 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:200343201-200344400 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2297 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:200378413-200378990 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:200378991-200379568 Neighboring gene NANOG hESC enhancer GRCh37_chr1:200379569-200380146 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr1:200380418-200381024 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200385505-200386006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200386007-200386506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388206-200388706 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:200388707-200389207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200396646-200397146 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:200397147-200397647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2299 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2300 Neighboring gene uncharacterized LOC124900414 Neighboring gene uncharacterized LOC124904480 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1671 Neighboring gene uncharacterized LOC107985459

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling. Qin CJ, et al. Cell Physiol Biochem, 2019. PMID 31112017
    2. Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis. Pierdomenico M, et al. Front Immunol, 2018. PMID 30619271, Free PMC Article
    3. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining. Nicolai S, et al. Oncogene, 2020 Jan. PMID 31570788, Free PMC Article
    4. ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis. Laudadio I, et al. Int J Mol Sci, 2022 Sep 6. PMID 36142169, Free PMC Article
    5. ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma. Pieraccioli M, et al. Proc Natl Acad Sci U S A, 2018 Jul 10. PMID 29941555, Free PMC Article

    See all (105) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.
      Title: Cancer-associated fibroblasts facilitate premetastatic niche formation through lncRNA SNHG5-mediated angiogenesis and vascular permeability in breast cancer.
    2. ZNF281 Promotes Colon Fibroblast Activation in TGFbeta1-Induced Gut Fibrosis.
      Title: ZNF281 Promotes Colon Fibroblast Activation in TGFβ1-Induced Gut Fibrosis.
    3. Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15.
      Title: Cervical carcinoma progression is aggravated by lncRNA ZNF281 by binding KLF15.
    4. ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
      Title: ZNF281/Zfp281 is a target of miR-1 and counteracts muscle differentiation.
    5. ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
      Title: ZNF281 is recruited on DNA breaks to facilitate DNA repair by non-homologous end joining.
    6. LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.
      Title: LncRNA-ZNF281 Interacts with miR-539 to Promote Hepatocellular Carcinoma Cell Invasion and Migration.
    7. Analyses indicated that circAGFG1 acts as a sponge for miR-203 to repress the effect of miR-203 on its target, ZNF281. In conclusion, study suggests that circAGFG1 promotes NSCLC growth and metastasis though a circAGFG1/miR-203/ZNF281 axis.
      Title: CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression.
    8. Data indicate transcription factor ZNF281 as a player of intestinal inflammation and fibrosis, and in the pathogenetic mechanisms underlying inflammatory bowel disease.
      Title: Transcription Factor ZNF281: A Novel Player in Intestinal Inflammation and Fibrosis.
    9. ZNF281 mRNA and protein levels were significantly increased in colorectal cancer (CRC) tissues compared with normal colon tissues, and high ZNF281 expression was associated with advanced T stage, N stage, TNM stage and differentiation. Therefore, ZNF281 expression might be an independent prognostic indicator in CRC patients.
      Title: ZNF281 Regulates Cell Proliferation, Migration and Invasion in Colorectal Cancer through Wnt/β-Catenin Signaling.
    10. These observations suggest that ZNF281 is a controller of neuronal differentiation that should be evaluated as a prognostic marker in neuroblastoma.
      Title: ZNF281 inhibits neuronal differentiation and is a prognostic marker for neuroblastoma.
    Submit: New GeneRIF Correction See all GeneRIFs (13)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • FLJ12859, FLJ14378

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in embryonic body morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in stem cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 281
    Names
    GC-box-binding zinc finger protein 1
    ZNP-99 transcription factor
    transcription factor ZBP-99
    zinc finger DNA-binding protein 99

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001281293.2 → NP_001268222.1  zinc finger protein 281 isoform 1

      See identical proteins and their annotated locations for NP_001268222.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC104461, AJ132592, BP216938
      Consensus CDS
      CCDS1402.1
      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
      Related
      ENSP00000356322.1, ENST00000367353.2
      Conserved Domains (2) summary
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    2. NM_001281294.2 → NP_001268223.1  zinc finger protein 281 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. The resulting protein (isoform 2) is missing an internal segment compared to isoform 1.
      Source sequence(s)
      AC104461, AK022921, AK094701, BC051905, BG611294, DB150929
      Consensus CDS
      CCDS60384.1
      UniProtKB/Swiss-Prot
      Q9Y2X9
      UniProtKB/TrEMBL
      B3KMX4
      Related
      ENSP00000356321.3, ENST00000367352.3
      Conserved Domains (3) summary
      sd00017
      Location:227 → 247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00096
      Location:225 → 247
      zf-C2H2; Zinc finger, C2H2 type
      pfam13465
      Location:295 → 320
      zf-H2C2_2; Zinc-finger double domain

    3. NM_012482.5 → NP_036614.1  zinc finger protein 281 isoform 1

      See identical proteins and their annotated locations for NP_036614.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript. Variants 1 and 2 encode the same protein (isoform 1).
      Source sequence(s)
      AC104461, BC060820
      Consensus CDS
      CCDS1402.1
      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
      Related
      ENSP00000294740.2, ENST00000294740.3
      Conserved Domains (2) summary
      sd00017
      Location:263 → 283
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:331 → 356
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      200404951..200410036 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      199661900..199740523 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054335706.1 → XP_054191681.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9

    2. XM_054335707.1 → XP_054191682.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9

    3. XM_054335708.1 → XP_054191683.1  zinc finger protein 281 isoform X1

      UniProtKB/Swiss-Prot
      A6NF48, B3KMX2, Q5RKW5, Q9NY92, Q9Y2X9
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Y2X9.1 GenPept UniProtKB/Swiss-Prot:Q9Y2X9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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