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    LOC127885275 H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:181157-181735 [ Homo sapiens (human) ]

    Gene ID: 127885275, updated on 12-Sep-2024

    Summary

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    Gene symbol
    LOC127885275
    Gene description
    H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:181157-181735
    Gene type
    biological region
    Feature type(s)
    regulatory: enhancer
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    This genomic region was validated as an active enhancer by the ChIP-STARR-seq massively parallel reporter assay in primed human embryonic stem cells. This enhancer is marked by the H3K27ac and H3K4me1 histone modifications. [provided by RefSeq, Dec 2022]
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    Genomic context

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    See LOC127885275 in Genome Data Viewer
    Location:
    chromosome: 17
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (331366..331944)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (250943..251521)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (181157..181735)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2091 Neighboring gene uncharacterized LOC124903889 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_47292 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:69190-69690 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:69691-70191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77137-77637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:77764-78286 Neighboring gene rabphilin 3A like (without C2 domains) Neighboring gene ReSE screen-validated silencer GRCh37_chr17:94284-94482 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:136075-136596 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:150673-151173 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:151415-152185 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:152186-152955 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:160317-161015 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:161016-161713 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr17:164601-165116 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:165117-165633 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:165634-166149 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:166152-166652 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:166653-167153 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:180576-181156 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:183692-184468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:184469-185243 Neighboring gene Sharpr-MPRA regulatory region 15212 Neighboring gene RPH3AL antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 2375 Neighboring gene uncharacterized LOC105371425 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr17:216819-218018 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr17:252557-253756 Neighboring gene uncharacterized LOC105371430 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7938 Neighboring gene ligand of ATE1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional Dissection of the Enhancer Repertoire in Human Embryonic Stem Cells. Barakat TS, et al. Cell Stem Cell, 2018 Aug 2. PMID 30033119, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See Variation Viewer (GRCh37.p13)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_135016.1 

      Range
      101..679
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      331366..331944
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NW_003315952.3 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      302801..303379
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_2

    Genomic

    1. NT_187662.1 Reference GRCh38.p14 ALT_REF_LOCI_2

      Range
      70694..71272 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      250943..251521
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version

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