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    PCYOX1 prenylcysteine oxidase 1 [ Homo sapiens (human) ]

    Gene ID: 51449, updated on 27-Nov-2024

    Summary

    Official Symbol
    PCYOX1provided by HGNC
    Official Full Name
    prenylcysteine oxidase 1provided by HGNC
    Primary source
    HGNC:HGNC:20588
    See related
    Ensembl:ENSG00000116005 MIM:610995; AllianceGenome:HGNC:20588
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCL1
    Summary
    Prenylcysteine is released during the degradation of prenylated proteins. PCYOX1 catalyzes the degradation of prenylcysteine to yield free cysteines and a hydrophobic isoprenoid product (Tschantz et al., 1999 [PubMed 10585463]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in fat (RPKM 61.1), kidney (RPKM 49.9) and 23 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See PCYOX1 in Genome Data Viewer
    Location:
    2p13.3
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (70257915..70281185)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (70269656..70292921)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (70485269..70508317)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 1285-2 Neighboring gene ribosomal protein L39 pseudogene 15 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11609 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11610 Neighboring gene small nuclear ribonucleoprotein polypeptide G Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:70519630-70520537 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16007 Neighboring gene uncharacterized LOC124906023 Neighboring gene family with sequence similarity 136 member A

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Phenotypes

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0908

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables FAD binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables farnesylcysteine lyase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables prenylcysteine oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables prenylcysteine oxidase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in prenylated protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in prenylated protein catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in prenylated protein catabolic process NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in prenylcysteine catabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    prenylcysteine oxidase 1
    Names
    prenylcysteine lyase
    NP_057381.3
    XP_047300645.1
    XP_054198442.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_016297.4NP_057381.3  prenylcysteine oxidase 1 precursor

      See identical proteins and their annotated locations for NP_057381.3

      Status: VALIDATED

      Source sequence(s)
      AC079338, AY359063, DC417137
      Consensus CDS
      CCDS1902.1
      UniProtKB/Swiss-Prot
      B2RB14, B7Z9P8, O94982, Q8N4N5, Q96QM8, Q9UHG3
      UniProtKB/TrEMBL
      B7Z8A2
      Related
      ENSP00000387654.2, ENST00000433351.7
      Conserved Domains (2) summary
      pfam07156
      Location:130494
      Prenylcys_lyase; Prenylcysteine lyase
      cl27535
      Location:48108
      Amino_oxidase; Flavin containing amine oxidoreductase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      70257915..70281185
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444689.1XP_047300645.1  prenylcysteine oxidase 1 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      70269656..70292921
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342467.1XP_054198442.1  prenylcysteine oxidase 1 isoform X1