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| Status |
Public on Mar 23, 2022 |
| Title |
Single cell RNA sequencing profiles on whole tumors from a Kras/Rnf43 genetically engineered mouse model of pancreatic adenocarcinoma |
| Organism |
Mus musculus |
| Experiment type |
Expression profiling by high throughput sequencing
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| Summary |
We report single cell RNA sequencing of pancreatic enzymatically digested whole, fresh tumors from a genetically engineered mouse model (GEMM) of pancreatic adenocarcinoma. This GEMM consists of pancreas specific expression of oncogenic Kras (Kras-G12D) in addition of homozygous deletion of the ring finger domain (catalytic domain) of Rnf43. This GEMM is termed 'KRC'.
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| Overall design |
KRC mice were sacraficed at prespecified time points: 2 months (early, n=2 mice), 4 months (intermediate, n=2 mice), moribund (n=3 mice)
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| Contributor(s) |
Hosein AN, Maitra A, Rajapakshe KI |
| Citation(s) |
34973294 |
| |
| Submission date |
Nov 16, 2021 |
| Last update date |
Mar 24, 2022 |
| Contact name |
Anirban Maitra |
| E-mail(s) |
AMaitra@mdanderson.org
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| Organization name |
The University of Texas MD Anderson Cancer Center
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| Department |
Translational Molecular Pathology
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| Lab |
Maitra laboratory
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| Street address |
6565 MD Anderson Blvd
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| City |
Houston |
| State/province |
TX |
| ZIP/Postal code |
77030 |
| Country |
USA |
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| Platforms (1) |
| GPL19057 |
Illumina NextSeq 500 (Mus musculus) |
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| Samples (10)
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| Relations |
| BioProject |
PRJNA780878 |
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