|
Status |
Public on Nov 22, 2012 |
Title |
Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status [expression] |
Platform organisms |
Schizosaccharomyces pombe; Saccharomyces cerevisiae |
Sample organism |
Saccharomyces cerevisiae |
Experiment type |
Expression profiling by array
|
Summary |
Cohesin acetylation by Eco1 during DNA replication establishes sister chromatid cohesion. We show that acetylation makes cohesin resistant to Wapl activity from S-phase until mitosis. Wapl turns out to be a key regulator of cohesin dynamics on chromosomes by controling cohesin maintenance following its establishment in S-phase and its role in chromosome condensation.
|
|
|
Overall design |
The Affymetrix Yeast Genome 2.0 Arrays were used to analyze the expression profile of wt and wapl∆ cells.
|
|
|
Contributor(s) |
Lopez-Serra L, Lengronne A, Borges V, Kelly G, Uhlmann F |
Citation(s) |
23219725 |
|
Submission date |
Nov 21, 2012 |
Last update date |
Feb 21, 2017 |
Contact name |
Rahul Thadani |
E-mail(s) |
rahul.thadani@cancer.org.uk
|
Organization name |
Cancer Research UK
|
Lab |
Chromosome Segregation
|
Street address |
44 Lincoln's Inn Fields
|
City |
London |
ZIP/Postal code |
WC2A 3LY |
Country |
United Kingdom |
|
|
Platforms (1) |
GPL2529 |
[Yeast_2] Affymetrix Yeast Genome 2.0 Array |
|
Samples (4)
|
|
This SubSeries is part of SuperSeries: |
GSE42460 |
Budding yeast Wapl controls sister chromatid cohesion maintenance and the chromosome condensation status |
|
Relations |
BioProject |
PRJNA182012 |