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| Status |
Public on Mar 31, 2014 |
| Title |
Inhibition of BET bromodomain proteins as a therapeutic approach in prostate cancer |
| Organism |
Homo sapiens |
| Experiment type |
Expression profiling by array
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| Summary |
We analyzed transcriptional changes in 4 prostate cancer cell lines following treatment with the BET inhibitor I-BET762 using Affymetrix Human Genome U133 Plus 2.0 Arrays.
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| Overall design |
Four prostate cancer cell lines (NCI-H660, VCaP, LNCaP, PC-3) were treated with DMSO (control) or I-BET762 at 0.5uM or 10uM concentrations for 24 hours. Two biological replicates are included for each treatment group.
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| Contributor(s) |
Wyce A, Degenhardt Y, Bai Y, Le B, Korenchuk S, Crouthamel M, McHugh CF, Vessella R, Creasy CL, Tummino PJ, Barbash O |
| Citation(s) |
24293458 |
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| Submission date |
Mar 31, 2014 |
| Last update date |
Mar 25, 2019 |
| Contact name |
Matteo Righi |
| E-mail(s) |
m.righi@autolus.com
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| Organization name |
Autolus Therapeutics
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| Street address |
The MediaWorks, 191 Wood Ln
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| City |
London |
| State/province |
London |
| ZIP/Postal code |
W12 7FP |
| Country |
United Kingdom |
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| Platforms (1) |
| GPL570 |
[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array |
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| Samples (24)
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| GSM1359760 |
NCIH660 DMSO vehicle at 24 hrs, Biological rep1 |
| GSM1359761 |
NCIH660 DMSO vehicle at 24 hrs, Biological rep2 |
| GSM1359762 |
NCIH660 GSK525762A .5uM at 24 hrs, Biological rep1 |
| GSM1359763 |
NCIH660 GSK525762A .5uM at 24 hrs, Biological rep2 |
| GSM1359764 |
NCIH660 GSK525762A 10uM at 24 hrs, Biological rep1 |
| GSM1359765 |
NCIH660 GSK525762A 10uM at 24 hrs, Biological rep2 |
| GSM1359766 |
VCAP DMSO vehicle at 24 hrs, Biological rep1 |
| GSM1359767 |
VCAP DMSO vehicle at 24 hrs, Biological rep2 |
| GSM1359768 |
VCAP GSK525762A .5uM at 24 hrs, Biological rep1 |
| GSM1359769 |
VCAP GSK525762A .5uM at 24 hrs, Biological rep2 |
| GSM1359770 |
VCAP GSK525762A 10uM at 24 hrs, Biological rep1 |
| GSM1359771 |
VCAP GSK525762A 10uM at 24 hrs, Biological rep2 |
| GSM1359772 |
LNCAP DMSO vehicle at 24 hrs, Biological rep1 |
| GSM1359773 |
LNCAP DMSO vehicle at 24 hrs, Biological rep2 |
| GSM1359774 |
LNCAP GSK525762A .5uM at 24 hrs, Biological rep1 |
| GSM1359775 |
LNCAP GSK525762A .5uM at 24 hrs, Biological rep2 |
| GSM1359776 |
LNCAP GSK525762A 10uM at 24 hrs, Biological rep1 |
| GSM1359777 |
LNCAP GSK525762A 10uM at 24 hrs, Biological rep2 |
| GSM1359778 |
PC3 DMSO vehicle at 24 hrs, Biological rep1 |
| GSM1359779 |
PC3 DMSO vehicle at 24 hrs, Biological rep2 |
| GSM1359780 |
PC3 GSK525762A .5uM at 24 hrs, Biological rep1 |
| GSM1359781 |
PC3 GSK525762A .5uM at 24 hrs, Biological rep2 |
| GSM1359782 |
PC3 GSK525762A 10uM at 24 hrs, Biological rep1 |
| GSM1359783 |
PC3 GSK525762A 10uM at 24 hrs, Biological rep2 |
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| Relations |
| BioProject |
PRJNA243023 |
| Supplementary file |
Size |
Download |
File type/resource |
| GSE56352_RAW.tar |
120.5 Mb |
(http)(custom) |
TAR (of CEL) |
| Processed data included within Sample table |
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