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Series GSE61723 Query DataSets for GSE61723
Status Public on Dec 02, 2015
Title Novel transcripts associated with lymph node metastasis in triple negative breast cancer [discovery cohort]
Organism Homo sapiens
Experiment type Expression profiling by array
Summary Triple negative breast cancer (TNBC) is the most aggressive breast cancer subtype with the worst prognosis. It is characterised by the absence of hormone receptors for estrogen, progesterone, and human epidermal growth factor 2, and as a consequence there are no targeted endocrine treatments available. TNBC patients are more likely to develop metastases and disease relapse than patients with other breast cancer subtypes. The identification of biomarkers that can be used to predict which patient is likely to develop metastatic disease remains a priority since this is the major cause of cancer-related death in these women.
 
Overall design A total of 33 grade 3 invasive ductal carcinomas were used in this study, from which we were able to compare 17 matched normal adjacent tissues from the tumour specimens and 15 lymph node metastases. Gene expression microarray analysis was used to reveal which transcripts were differentially expressed between patients with lymph node involvement and those who only presented with a primary tumour.
 
Contributor(s) Mathe A, Avery-Kiejda KA, Wong-Brown M, Morten B, Forbes JF, Braye SG, Scott RJ
Citation(s) 26537449, 34225099
Submission date Sep 24, 2014
Last update date Jul 20, 2021
Contact name Kelly Kiejda
E-mail(s) Kelly.Kiejda@newcastle.edu.au
Organization name University of Newcastle
Street address HMRI
City New Lambton Heights
State/province NSW
ZIP/Postal code 2305
Country Australia
 
Platforms (1)
GPL16686 [HuGene-2_0-st] Affymetrix Human Gene 2.0 ST Array [transcript (gene) version]
Samples (65)
GSM1511737 patient 1 IDC
GSM1511738 patient 2 IDC
GSM1511739 patient 3 IDC
This SubSeries is part of SuperSeries:
GSE61725 Novel transcripts associated with lymph node metastasis in triple negative breast cancer
Relations
BioProject PRJNA261957

Download family Format
SOFT formatted family file(s) SOFTHelp
MINiML formatted family file(s) MINiMLHelp
Series Matrix File(s) TXTHelp

Supplementary file Size Download File type/resource
GSE61723_RAW.tar 441.6 Mb (http)(custom) TAR (of CEL)
Processed data included within Sample table

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