SAM1 methionine adenosyltransferase SAM1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SAM1
Gene description: methionine adenosyltransferase SAM1
Primary source: FungiDB:YLR180W
Locus tag: YLR180W
See related: SGD:S000004170; AllianceGenome:SGD:S000004170; VEuPathDB:YLR180W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ETH10
Summary: Enables methionine adenosyltransferase activity. Involved in S-adenosylmethionine biosynthetic process and methionine metabolic process. Acts upstream of or within negative regulation of stress granule assembly. Located in cytoplasmic stress granule. Human ortholog(s) of this gene implicated in hypermethioninemia. Orthologous to human MAT1A (methionine adenosyltransferase 1A) and MAT2A (methionine adenosyltransferase 2A). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SAM1 in Genome Data Viewer

Location:: chromosome: XII

Exon count:: 1

Sequence:: Chromosome: XII; NC_001144.5 (515262..516410)

Chromosome XII - NC_001144.5 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001144.5

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SAM1 and SAM2 have different effects on genome stability through distinctive effects on gene expression and AdoMet levels.
Title: Mutations in the S-Adenosylmethionine Synthetase Genes SAM1 and SAM2 Differentially Affect Genome Stability in Saccharomyces cerevisiae.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables methionine adenosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables methionine adenosyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in S-adenosylmethionine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in S-adenosylmethionine biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in S-adenosylmethionine biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in methionine metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of stress granule assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in one-carbon metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasmic stress granule	HDA more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: methionine adenosyltransferase SAM1

NP_013281.1

EC 2.5.1.6

S-adenosylmethionine synthetase; catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; SAM1 has a paralog, SAM2, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001144.5 Reference assembly

Range

515262..516410

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001182067.1 → NP_013281.1 TPA: methionine adenosyltransferase SAM1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_013281.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VYI4, P10659

UniProtKB/TrEMBL

A0A6A5PQV9, A7A171, B3RH72, B5VN99, C7GIW9, N1NYC1

Conserved Domains (1) summary

cd18079
Location:6 → 378

S-AdoMet_synt; S-adenosylmethionine synthetase