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    ARC40 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852536, updated on 11-Sep-2024

    Summary

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    Official Symbol
    ARC40
    Primary source
    SGD:S000000438
    Locus tag
    YBR234C
    See related
    AllianceGenome:SGD:S000000438; FungiDB:YBR234C; VEuPathDB:YBR234C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables ubiquitin binding activity. Involved in actin cortical patch organization and positive regulation of Arp2/3 complex-mediated actin nucleation. Part of Arp2/3 protein complex. Human ortholog(s) of this gene implicated in gastritis; immunodeficiency 71; myelodysplastic syndrome; and pancreatic cancer. Orthologous to human ARPC1A (actin related protein 2/3 complex subunit 1A) and ARPC1B (actin related protein 2/3 complex subunit 1B). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (685438..686592, complement)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Pbp2p Neighboring gene Dad3p Neighboring gene Vhc1p Neighboring gene mRNA (guanine-N7)-methyltransferase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. In vivo mRNA display enables large-scale proteomics by next generation sequencing. Oikonomou P, et al. Proc Natl Acad Sci U S A, 2020 Oct 27. PMID 33037152, Free PMC Article
    2. The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation. Balcer HI, et al. J Biol Chem, 2010 Mar 12. PMID 20071330, Free PMC Article
    3. Affinity filtration coupled with capillary-based affinity purification for the isolation of protein complexes. Qureshi MS, et al. Anal Biochem, 2013 Aug 1. PMID 23583819
    4. Purification of Arp2/3 complex from Saccharomyces cerevisiae. Doolittle LK, et al. Methods Mol Biol, 2013. PMID 23868593, Free PMC Article
    5. Functional surfaces on the p35/ARPC2 subunit of Arp2/3 complex required for cell growth, actin nucleation, and endocytosis. Daugherty KM, et al. J Biol Chem, 2008 Jun 13. PMID 18381280, Free PMC Article

    See all (52) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. p40/ARPC1 performs at least three distinct, essential functions in regulating Arp2/3 complex-mediated actin assembly
      Title: The p40/ARPC1 subunit of Arp2/3 complex performs multiple essential roles in WASp-regulated actin nucleation.
    2. study showed that subunit ARPC1/Arc40 of the yeast actin-related protein Arp2/3 complex is indeed a stable component of the complex and contains an important contact site for the VCA domain of Wiskott-Aldrich syndrome protein family activators
      Title: ARPC1/Arc40 mediates the interaction of the actin-related protein 2 and 3 complex with Wiskott-Aldrich syndrome protein family activators.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Arp2/3 complex-mediated actin nucleation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Arp2/3 complex-mediated actin nucleation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in actin cortical patch organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in positive regulation of Arp2/3 complex-mediated actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of Arp2/3 protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Arp2/3 protein complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of Arp2/3 protein complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cortical patch IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in actin cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Arc40p
    NP_009793.1
    • Subunit of the ARP2/3 complex; ARP2/3 is required for the motility and integrity of cortical actin patches

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      685438..686592 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178582.1 → NP_009793.1  TPA: Arc40p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009793.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQN0, P38328
      UniProtKB/TrEMBL
      A6ZLH3, B3LMS8, B5VEI3, C7GMR9, G2W9N7, N1P9L6
      Conserved Domains (2) summary
      COG2319
      Location:5 → 315
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:22 → 61
      7WD40; WD40 repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P38328.1

    Gene LinkOut

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