IRC15 Irc15p [Saccharomyces cerevisiae S288C] - Gene

Summary

Gene symbol: IRC15
Gene description: Irc15p
Primary source: FungiDB:YPL017C
Locus tag: YPL017C
See related: SGD:S000005938; AllianceGenome:SGD:S000005938; VEuPathDB:YPL017C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Enables microtubule binding activity and oxidoreductase activity, acting on NAD(P)H. Involved in several processes, including microtubule cytoskeleton organization; mitotic recombination; and sister chromatid segregation. Located in microtubule. Human ortholog(s) of this gene implicated in maple syrup urine disease. Orthologous to human DLD (dihydrolipoamide dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Chromosome XVI - NC_001148.4 Genomic Context describing neighboring genes

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables dihydrolipoyl dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables flavin adenine dinucleotide binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on NAD(P)H	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in attachment of mitotic spindle microtubules to kinetochore	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in meiotic sister chromatid segregation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule anchoring	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in microtubule nucleation	IDA Inferred from Direct Assay more info	PubMed
involved_in mitotic recombination	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	HDA more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
part_of oxoglutarate dehydrogenase complex	IBA Inferred from Biological aspect of Ancestor more info

NP_015308.1

Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci; IRC15 has a paralog, LPD1, that arose from the whole genome duplication

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The following sections contain reference sequences that belong to a specific genome build. Explain