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    Crocc2 ciliary rootlet coiled-coil, rootletin family member 2 [ Mus musculus (house mouse) ]

    Gene ID: 381284, updated on 17-Aug-2024

    Summary

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    Official Symbol
    Crocc2provided by MGI
    Official Full Name
    ciliary rootlet coiled-coil, rootletin family member 2provided by MGI
    Primary source
    MGI:MGI:3045962
    See related
    Ensembl:ENSMUSG00000084989 AllianceGenome:MGI:3045962
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm976; E030010N08Rik
    Summary
    Is expressed in central nervous system; dorsal root ganglion; embryo mesenchyme; and lung. Orthologous to human CROCC2 (ciliary rootlet coiled-coil, rootletin family member 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in ovary adult (RPKM 2.5), lung adult (RPKM 1.1) and 6 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Crocc2 in Genome Data Viewer
    Location:
    1 D; 1 47.17 cM
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (93096145..93158789)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (93168423..93231067)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene alanine-glyoxylate aminotransferase Neighboring gene mab-21-like 4 Neighboring gene STARR-seq mESC enhancer starr_01724 Neighboring gene STARR-seq mESC enhancer starr_01726 Neighboring gene sushi, nidogen and EGF-like domains 1 Neighboring gene microRNA 6901 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:95202393-95202604 Neighboring gene mitochondrial transcription termination factor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification of FOXJ1 effectors during ciliogenesis in the foetal respiratory epithelium and embryonic left-right organiser of the mouse. Stauber M, et al. Dev Biol, 2017 Mar 15. PMID 27914912
    2. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    3. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    4. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073
    5. High-efficiency full-length cDNA cloning. Carninci P, et al. Methods Enzymol, 1999. PMID 10349636

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in centriole IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    ciliary rootlet coiled-coil protein 2
    Names
    putative ciliary rootlet coiled-coil protein 2

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001310428.1 → NP_001297357.1  ciliary rootlet coiled-coil protein 2

      Status: PROVISIONAL

      Source sequence(s)
      AC103673, AC124669
      Consensus CDS
      CCDS78654.1
      UniProtKB/Swiss-Prot
      F6XLV1
      Related
      ENSMUSP00000120588.3, ENSMUST00000138595.3
      Conserved Domains (2) summary
      TIGR02168
      Location:431 → 1248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:128 → 259
      Rootletin; Ciliary rootlet component, centrosome cohesion

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      93096145..93158789
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006529983.2 → XP_006530046.1  ciliary rootlet coiled-coil protein 2 isoform X1

      Conserved Domains (2) summary
      TIGR02168
      Location:435 → 1248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:119 → 259
      Rootletin; Ciliary rootlet component, centrosome cohesion

    2. XM_006529986.2 → XP_006530049.1  ciliary rootlet coiled-coil protein 2 isoform X4

      Conserved Domains (2) summary
      TIGR02168
      Location:435 → 1248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:119 → 259
      Rootletin; Ciliary rootlet component, centrosome cohesion

    3. XM_036166086.1 → XP_036021979.1  ciliary rootlet coiled-coil protein 2 isoform X5

      Conserved Domains (2) summary
      TIGR02168
      Location:435 → 1241
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:128 → 259
      Rootletin; Ciliary rootlet component, centrosome cohesion

    4. XM_006529984.2 → XP_006530047.1  ciliary rootlet coiled-coil protein 2 isoform X2

      Conserved Domains (2) summary
      TIGR02168
      Location:433 → 1246
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:119 → 257
      Rootletin; Ciliary rootlet component, centrosome cohesion

    5. XM_030255127.1 → XP_030110987.1  ciliary rootlet coiled-coil protein 2 isoform X6

      Conserved Domains (2) summary
      TIGR02168
      Location:290 → 1103
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:18 → 114
      Rootletin; Ciliary rootlet component, centrosome cohesion

    6. XM_006529994.2 → XP_006530057.1  ciliary rootlet coiled-coil protein 2 isoform X9

      See identical proteins and their annotated locations for XP_006530057.1

      Conserved Domains (2) summary
      TIGR02168
      Location:435 → 1248
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:119 → 259
      Rootletin; Ciliary rootlet component, centrosome cohesion

    7. XM_006529985.2 → XP_006530048.1  ciliary rootlet coiled-coil protein 2 isoform X3

      Conserved Domains (2) summary
      TIGR02168
      Location:432 → 1245
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:116 → 256
      Rootletin; Ciliary rootlet component, centrosome cohesion

    8. XM_006529991.3 → XP_006530054.1  ciliary rootlet coiled-coil protein 2 isoform X7

      Conserved Domains (2) summary
      TIGR02168
      Location:272 → 1085
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type
      pfam15035
      Location:2 → 96
      Rootletin; Ciliary rootlet component, centrosome cohesion

    9. XM_006529992.2 → XP_006530055.1  ciliary rootlet coiled-coil protein 2 isoform X8

      Conserved Domains (1) summary
      TIGR02168
      Location:264 → 1077
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RNA

    1. XR_004942947.1 RNA Sequence

    2. XR_003956157.1 RNA Sequence

    3. XR_003956159.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F6XLV1.2 GenPept UniProtKB/Swiss-Prot:F6XLV1

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