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    Stard6 StAR related lipid transfer domain containing 6 [ Mus musculus (house mouse) ]

    Gene ID: 170461, updated on 9-Aug-2024

    Summary

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    Official Symbol
    Stard6provided by MGI
    Official Full Name
    StAR related lipid transfer domain containing 6provided by MGI
    Primary source
    MGI:MGI:2156774
    See related
    Ensembl:ENSMUSG00000079608 AllianceGenome:MGI:2156774
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1700011K09Rik; 4833424I06Rik; 4933429L05Rik
    Summary
    Predicted to enable cholesterol binding activity. Predicted to act upstream of or within lipid transport. Orthologous to human STARD6 (StAR related lipid transfer domain containing 6). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 26.3) and frontal lobe adult (RPKM 0.4) See more
    Orthologs
    human all
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    Genomic context

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    See Stard6 in Genome Data Viewer
    Location:
    18 E2; 18 44.44 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70605525..70638325)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (70472454..70505254)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_44960 Neighboring gene dynactin associated protein like 1 Neighboring gene STARR-seq mESC enhancer starr_44961 Neighboring gene STARR-seq mESC enhancer starr_44962 Neighboring gene predicted gene, 31620 Neighboring gene RIKEN cDNA 4930503L19 gene Neighboring gene STARR-positive B cell enhancer ABC_E11002 Neighboring gene STARR-positive B cell enhancer ABC_E1519 Neighboring gene STARR-positive B cell enhancer ABC_E8725 Neighboring gene microRNA 6357 Neighboring gene polymerase (DNA directed), iota Neighboring gene CapStarr-seq enhancer MGSCv37_chr18:70722848-70723181 Neighboring gene STARR-seq mESC enhancer starr_44965 Neighboring gene predicted gene, 31671 Neighboring gene methyl-CpG binding domain protein 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. StAR-like activity and molten globule behavior of StARD6, a male germ-line protein. Bose HS, et al. Biochemistry, 2008 Feb 26. PMID 18211099
    2. Analysis of the Par2 modifier of pulmonary adenoma formation in mice. Wang M, et al. Exp Lung Res, 2005 Mar. PMID 15828125
    3. The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6. Soccio RE, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 12011452, Free PMC Article
    4. Crystal structure of the Mus musculus cholesterol-regulated START protein 4 (StarD4) containing a StAR-related lipid transfer domain. Romanowski MJ, et al. Proc Natl Acad Sci U S A, 2002 May 14. PMID 12011453, Free PMC Article
    5. Gene mapping of sperm quality parameters in recombinant inbred strains of mice. Golas A, et al. Int J Dev Biol, 2008. PMID 18311719

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (1) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107178

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables cholesterol binding ISA
    Inferred from Sequence Alignment
    more info
    		 PubMed 
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    acts_upstream_of_or_within lipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    stAR-related lipid transfer protein 6
    Names
    START domain containing protein 6
    StAR-related lipid transfer (START) domain containing 6

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001289648.1 → NP_001276577.1  stAR-related lipid transfer protein 6

      See identical proteins and their annotated locations for NP_001276577.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK014759, BE691268, BY085273, JF440953
      Consensus CDS
      CCDS37854.1
      UniProtKB/Swiss-Prot
      P59096
      UniProtKB/TrEMBL
      Q9CPT8, R4HJA5
      Related
      ENSMUSP00000130991.3, ENSMUST00000168249.9
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. NM_001289649.1 → NP_001276578.1  stAR-related lipid transfer protein 6

      See identical proteins and their annotated locations for NP_001276578.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK014759, AK016984, BE691268, JF440953
      Consensus CDS
      CCDS37854.1
      UniProtKB/Swiss-Prot
      P59096
      UniProtKB/TrEMBL
      Q9CPT8, R4HJA5
      Related
      ENSMUSP00000126055.2, ENSMUST00000164223.8
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    3. NM_001289650.1 → NP_001276579.1  stAR-related lipid transfer protein 6

      See identical proteins and their annotated locations for NP_001276579.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AK005873, AK014759, BE691268
      Consensus CDS
      CCDS37854.1
      UniProtKB/Swiss-Prot
      P59096
      UniProtKB/TrEMBL
      Q9CPT8, R4HJA5
      Related
      ENSMUSP00000134511.2, ENSMUST00000174118.8
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    4. NM_029019.4 → NP_083295.1  stAR-related lipid transfer protein 6

      See identical proteins and their annotated locations for NP_083295.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2, 3, and 4 encode the same protein.
      Source sequence(s)
      AC162297, AK014759, BE691268
      Consensus CDS
      CCDS37854.1
      UniProtKB/Swiss-Prot
      P59096
      UniProtKB/TrEMBL
      Q9CPT8, R4HJA5
      Related
      ENSMUSP00000110609.3, ENSMUST00000114959.9
      Conserved Domains (1) summary
      cl14643
      Location:1 → 204
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      70605525..70638325
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036161003.1 → XP_036016896.1  stAR-related lipid transfer protein 6 isoform X1

      UniProtKB/TrEMBL
      R4HJA5
      Conserved Domains (1) summary
      cl14643
      Location:1 → 202
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily

    2. XM_011246853.1 → XP_011245155.1  stAR-related lipid transfer protein 6 isoform X2

      Conserved Domains (1) summary
      cl14643
      Location:3 → 117
      SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P59096.1 GenPept UniProtKB/Swiss-Prot:P59096

    Gene LinkOut

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