Msmp microseminoprotein, prostate associated [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Msmpprovided by MGI
Official Full Name: microseminoprotein, prostate associatedprovided by MGI
Primary source: MGI:MGI:3652339
See related: Ensembl:ENSMUSG00000078719 AllianceGenome:MGI:3652339
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Psmp
Summary: Predicted to enable CCR2 chemokine receptor binding activity. Predicted to be involved in lymphocyte chemotaxis and monocyte chemotaxis. Predicted to act upstream of or within chemotaxis and inflammatory response. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and extracellular space. Orthologous to human MSMP (microseminoprotein, prostate associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in ovary adult (RPKM 29.8), thymus adult (RPKM 27.2) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 4 A5; 4 23.05 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (43583216..43584494, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (43583216..43584494, complement)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.
Title: The novel potential therapeutic target PSMP/MSMP promotes acute kidney injury via CCR2.
PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
Title: PSMP/MSMP promotes hepatic fibrosis through CCR2 and represents a novel therapeutic target.
High MSMP expression is associated with drug-resistant prostate cancer.
Title: Induction of anti-VEGF therapy resistance by upregulated expression of microseminoprotein (MSMP).
Study shows that PSMP plays a vital role in promoting dextran sodium sulfate (DSS)-colitis. PSMP is significantly up-regulated DSS-induced mouse colitis. PSMP is up-regulated in the initial stage prior to IL-6, TNF-alpha and CCL2 up-regulated expression in DSS colitis and promote the M1 macrophages to produce CCL2. PMSP affects the monocytes and macrophages through CCR2.
Title: The PSMP-CCR2 interactions trigger monocyte/macrophage-dependent colitis.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables CCR2 chemokine receptor binding	ISO Inferred from Sequence Orthology more info
enables CCR2 chemokine receptor binding	ISS Inferred from Sequence or Structural Similarity more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in lymphocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in lymphocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in monocyte chemotaxis	ISO Inferred from Sequence Orthology more info
involved_in monocyte chemotaxis	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostate-associated microseminoprotein

Names: PC3-secreted microprotein homolog; Vmicroseminoprotein, prostate associated

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.