Krt40 keratin 40 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Krt40provided by MGI
Official Full Name: keratin 40provided by MGI
Primary source: MGI:MGI:3629968
See related: Ensembl:ENSMUSG00000059169 AllianceGenome:MGI:3629968
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: K40; CK-40
Summary: Predicted to enable structural molecule activity. Predicted to be located in intermediate filament. Is expressed in hair. Orthologous to human KRT40 (keratin 40). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 62.92 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (99427561..99434046, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (99536735..99543220, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural molecule activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in epithelial cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intermediate filament organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in intermediate filament	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: keratin, type I cytoskeletal 40

Names: cytokeratin-40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001039666.3 → NP_001034755.1 keratin, type I cytoskeletal 40 isoform 1

See identical proteins and their annotated locations for NP_001034755.1

Status: VALIDATED

Source sequence(s)

AL591417

Consensus CDS

CCDS36307.1

UniProtKB/Swiss-Prot

A0AUL0, Q3B7Y6, Q6IFX3

UniProtKB/TrEMBL

Q0VDU1

Related

ENSMUSP00000073869.4, ENSMUST00000074253.4

Conserved Domains (2) summary

pfam00038
Location:88 → 399

Filament; Intermediate filament protein

cl09111
Location:282 → 348

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...
NM_001317213.2 → NP_001304142.1 keratin, type I cytoskeletal 40 isoform 2

Status: VALIDATED

Source sequence(s)

AL591417

Consensus CDS

CCDS83897.1

UniProtKB/TrEMBL

E9PV64, Q0VDU1

Related

ENSMUSP00000103067.2, ENSMUST00000107443.8

Conserved Domains (2) summary

pfam00038
Location:88 → 319

Filament; Intermediate filament protein

cl09111
Location:202 → 268

Prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits ...