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    IDO2 indoleamine 2,3-dioxygenase 2 [ Homo sapiens (human) ]

    Gene ID: 169355, updated on 2-Nov-2024

    Summary

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    Official Symbol
    IDO2provided by HGNC
    Official Full Name
    indoleamine 2,3-dioxygenase 2provided by HGNC
    Primary source
    HGNC:HGNC:27269
    See related
    Ensembl:ENSG00000188676 MIM:612129; AllianceGenome:HGNC:27269
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INDOL1
    Summary
    Along with the enzymes encoded by the INDO (MIM 147435) and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 gene metabolizes tryptophan in the kynurenine pathway (Ball et al., 2007 [PubMed 17499941]).[supplied by OMIM, Feb 2011]
    Expression
    Biased expression in placenta (RPKM 9.5), liver (RPKM 2.8) and 3 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See IDO2 in Genome Data Viewer
    Location:
    8p11.21
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (39934651..40016392)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (40211488..40293321)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (39792170..39873911)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L7a pseudogene 80 Neighboring gene Sharpr-MPRA regulatory region 12355 Neighboring gene polo like kinase 4 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:39807747-39808491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27279 Neighboring gene indoleamine 2,3-dioxygenase 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:39835255-39836184 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39836330-39836562 Neighboring gene Sharpr-MPRA regulatory region 1248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27280 Neighboring gene nuclear transcription factor Y subunit beta pseudogene Neighboring gene Sharpr-MPRA regulatory region 3146 Neighboring gene ReSE screen-validated silencer GRCh37_chr8:39908434-39908606 Neighboring gene HNF4 motif-containing MPRA enhancer 150 Neighboring gene long intergenic non-protein coding RNA 2866 Neighboring gene HNF1 motif-containing MPRA enhancer 269 Neighboring gene transcriptional and immune response regulator Neighboring gene NANOG hESC enhancer GRCh37_chr8:40077338-40077937 Neighboring gene NANOG hESC enhancer GRCh37_chr8:40194220-40194743 Neighboring gene SIRT1 regulating lncRNA tumor promoter

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function. Suvieri C, et al. Int J Mol Sci, 2023 Nov 12. PMID 38003426, Free PMC Article
    2. The human indoleamine 2,3-dioxygenase gene and related human genes. Murray MF. Curr Drug Metab, 2007 Apr. PMID 17430106
    3. Genotyping and expression analysis of IDO2 in human pancreatic cancer: a novel, active target. Witkiewicz AK, et al. J Am Coll Surg, 2009 May. PMID 19476837, Free PMC Article
    4. High activity of indoleamine 2,3 dioxygenase enzyme predicts disease severity and case fatality in bacteremic patients. Huttunen R, et al. Shock, 2010 Feb. PMID 19487973
    5. Induction of indoleamine 2, 3-dioxygenase by death receptor activation contributes to apoptosis of melanoma cells via mitochondrial damage-dependent ROS accumulation. Cetindere T, et al. Cell Signal, 2010 Feb. PMID 19799997

    See all (45) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Marked IDO2 expression and activity related to autophagy and apoptosis in brain tissue of fatal tuberculous meningitis.
      Title: Marked IDO2 expression and activity related to autophagy and apoptosis in brain tissue of fatal tuberculous meningitis.
    2. Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function.
      Title: Membrane Localization and Phosphorylation of Indoleamine 2,3-Dioxygenase 2 (IDO2) in A549 Human Lung Adenocarcinoma Cells: First Steps in Exploring Its Signaling Function.
    3. Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
      Title: Prolonged indoleamine 2,3-dioxygenase-2 activity and associated cellular stress in post-acute sequelae of SARS-CoV-2 infection.
    4. Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer.
      Title: Regulation of IDO2 by the Aryl Hydrocarbon Receptor (AhR) in Breast Cancer.
    5. Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects.
      Title: Indoleamine 2,3-dioxygenase 2 immunohistochemical expression in medullary thyroid carcinoma: implications in prognosis and immunomodulatory effects.
    6. Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
      Title: Heterozygote Advantage of the Type II Deiodinase Thr92Ala Polymorphism on Intrahospital Mortality of COVID-19.
    7. Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
      Title: Indoleamine 2,3-dioxygenase (IDO)-1 and IDO-2 activity and severe course of COVID-19.
    8. Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients.
      Title: Single-nucleotide polymorphisms and activities of indoleamine 2,3-dioxygenase isoforms, IDO1 and IDO2, in tuberculosis patients.
    9. IDO2 rs10109853 polymorphism affects the susceptibility to multiple myeloma.
      Title: IDO2 rs10109853 polymorphism affects the susceptibility to multiple myeloma.
    10. Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
      Title: Investigating the Role of Indoleamine 2,3-Dioxygenase in Acute Myeloid Leukemia: A Systematic Review.
    Submit: New GeneRIF Correction See all GeneRIFs (38)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    An atlas of genetic influences on human blood metabolites.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables heme binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables indoleamine 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables indoleamine 2,3-dioxygenase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables indoleamine 2,3-dioxygenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables tryptophan 2,3-dioxygenase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in 'de novo' NAD biosynthetic process from tryptophan IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in tryptophan catabolic process to kynurenine IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in tryptophan catabolic process to kynurenine ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    indoleamine 2,3-dioxygenase 2
    Names
    indoleamine 2,3-dioxygenase-like 1 protein
    indoleamine 2,3-dioxygenase-like protein 1
    indoleamine-pyrrole 2,3 dioxygenase-like 1
    indoleamine-pyrrole 2,3-dioxygenase-like protein 1
    NP_001382135.1
    NP_919270.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395206.1 → NP_001382135.1  indoleamine 2,3-dioxygenase 2

      Status: VALIDATED

      Source sequence(s)
      AC007991, AC087518
      Consensus CDS
      CCDS6114.3
      UniProtKB/Swiss-Prot
      A4UD41, F5H5G0, Q6ZQW0
      Conserved Domains (1) summary
      pfam01231
      Location:15 → 401
      IDO; Indoleamine 2,3-dioxygenase

    2. NM_194294.5 → NP_919270.3  indoleamine 2,3-dioxygenase 2

      Status: VALIDATED

      Source sequence(s)
      AC007991, AC087518
      Consensus CDS
      CCDS6114.3
      UniProtKB/Swiss-Prot
      A4UD41, F5H5G0, Q6ZQW0
      Related
      ENSP00000443432.2, ENST00000502986.4
      Conserved Domains (1) summary
      pfam01231
      Location:15 → 401
      IDO; Indoleamine 2,3-dioxygenase

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      39934651..40016392
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      40211488..40293321
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZQW0.5 GenPept UniProtKB/Swiss-Prot:Q6ZQW0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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