mt-Nd4l NADH dehydrogenase 4L, mitochondrial [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: mt-Nd4lprovided by MGI
Official Full Name: NADH dehydrogenase 4L, mitochondrialprovided by MGI
Primary source: MGI:MGI:102497
See related: AllianceGenome:MGI:102497
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus (strain: C57BL/6J)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ND4L
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to be involved in ATP synthesis coupled electron transport. Located in mitochondrion. Human ortholog(s) of this gene implicated in Leber hereditary optic neuropathy and diabetes mellitus. Orthologous to human MT-ND4L (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 4L). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	MT (non-nuclear)	NC_005089.1 (9877..10173)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	MT (non-nuclear)	NC_005089.1 (9877..10173)

Chromosome MT - NC_005089.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Spontaneous (1) 1 citation

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH125504 (e-PCR)
- UniSTS:162322

RH136484 (e-PCR)
- UniSTS:210468

mt-Co3 (e-PCR), detects polymorphism
- UniSTS:143918

mt-Nd3 (e-PCR), detects polymorphism
- UniSTS:143919

RH136233 (e-PCR)
- UniSTS:210227

RH136521 (e-PCR)
- UniSTS:210503

RH136532 (e-PCR)
- UniSTS:210514

RH136545 (e-PCR)
- UniSTS:210527

RH136286 (e-PCR)
- UniSTS:210279

NoName (e-PCR)
- UniSTS:234089

NoName (e-PCR)
- UniSTS:234091

NoName (e-PCR)
- UniSTS:234092

NoName (e-PCR)
- UniSTS:234093

NoName (e-PCR)
- UniSTS:234094

NoName (e-PCR)
- UniSTS:234095

RH136564 (e-PCR)
- UniSTS:210544

RH136324 (e-PCR)
- UniSTS:210315

RH136327 (e-PCR)
- UniSTS:210317

RH136387 (e-PCR)
- UniSTS:210377

RH136397 (e-PCR)
- UniSTS:210387

RH136401 (e-PCR)
- UniSTS:210391

RH136408 (e-PCR)
- UniSTS:210398

RH125467 (e-PCR)
- UniSTS:162286

RH125521 (e-PCR)
- UniSTS:162286

RH125483 (e-PCR)
- UniSTS:162302

Homology

Orthologs from OrthoDB

URF4L

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity, acting on NAD(P)H	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ATP synthesis coupled electron transport	IEA Inferred from Electronic Annotation more info
involved_in aerobic respiration	NAS Non-traceable Author Statement more info	PubMed
involved_in proton motive force-driven mitochondrial ATP synthesis	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
part_of respirasome	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of respiratory chain complex I	ISO Inferred from Sequence Orthology more info

General protein information

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Names: NADH dehydrogenase subunit 4L

NP_904336.1

EC 1.6.5.3

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_005089.1 Reference assembly

Range

9877..10173

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NP_904336.1 NADH dehydrogenase subunit 4L (mitochondrion) [Mus musculus]

See identical proteins and their annotated locations for NP_904336.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P03903

UniProtKB/TrEMBL

A0A0C4G448, Q7JD00, Q7YBV2, Q9MD77

Related

ENSMUSP00000081021.1

Conserved Domains (1) summary

MTH00107
Location:1 → 98

ND4L; NADH dehydrogenase subunit 4L; Provisional