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    MRK1 putative serine/threonine protein kinase MRK1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851480, updated on 17-May-2024

    Summary

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    Gene symbol
    MRK1
    Gene description
    putative serine/threonine protein kinase MRK1
    Primary source
    FungiDB:YDL079C
    Locus tag
    YDL079C
    See related
    SGD:S000002237; AllianceGenome:SGD:S000002237; VEuPathDB:YDL079C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Predicted to enable protein serine/threonine kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including cellular response to heat; cellular response to salt stress; and protein phosphorylation. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; bipolar disorder; and schizophrenia. Orthologous to human GSK3A (glycogen synthase kinase 3 alpha) and GSK3B (glycogen synthase kinase 3 beta). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MRK1 in Genome Data Viewer
    Location:
    chromosome: IV
    Exon count:
    2
    Sequence:
    Chromosome: IV; NC_001136.10 (312951..314748, complement)

    Chromosome IV - NC_001136.10Genomic Context describing neighboring genes Neighboring gene ribosomal protein P1A Neighboring gene branched-chain-2-oxoacid decarboxylase THI3 Neighboring gene malate dehydrogenase MDH3 Neighboring gene Vam6p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001136.10

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Novel Saccharomyces cerevisiae gene, MRK1, encoding a putative protein kinase with similarity to mammalian glycogen synthase kinase-3 and Drosophila Zeste-White3/Shaggy. Hardy TA, et al. Biochem Biophys Res Commun, 1995 Mar 17. PMID 7695629
    2. Glycogen synthase kinase-3 is involved in regulation of ribosome biogenesis in yeast. Yabuki Y, et al. Biosci Biotechnol Biochem, 2014. PMID 25035982
    3. Developmentally regulated internal transcription initiation during meiosis in budding yeast. Zhou S, et al. PLoS One, 2017. PMID 29136644, Free PMC Article
    4. The Saccharomyces cerevisiae GSK-3 beta homologs. Kassir Y, et al. Curr Drug Targets, 2006 Nov. PMID 17100585
    5. Yeast glycogen synthase kinase-3 activates Msn2p-dependent transcription of stress responsive genes. Hirata Y, et al. Mol Biol Cell, 2003 Jan. PMID 12529445, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein serine/threonine kinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein serine/threonine kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine/tyrosine kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in peptidyl-threonine phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of protein catabolic process IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    putative serine/threonine protein kinase MRK1
    NP_010204.1
    • Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation; MRK1 has a paralog, RIM11, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001136.10 Reference assembly

      Range
      312951..314748 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180138.1 → NP_010204.1  TPA: putative serine/threonine protein kinase MRK1 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_010204.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VRS0, P50873, Q07470
      UniProtKB/TrEMBL
      C8Z4J1, N1PA98
      Conserved Domains (1) summary
      cd14137
      Location:159 → 449
      STKc_GSK3; The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50873.2

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