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    DSE4 endo-1,3(4)-beta-glucanase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855804, updated on 29-Jun-2024

    Summary

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    Gene symbol
    DSE4
    Gene description
    endo-1,3(4)-beta-glucanase
    Primary source
    FungiDB:YNR067C
    Locus tag
    YNR067C
    See related
    SGD:S000005350; AllianceGenome:SGD:S000005350; VEuPathDB:YNR067C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    ENG1
    Summary
    Enables glucan endo-1,3-beta-D-glucosidase activity. Involved in septum digestion after cytokinesis. Located in cell septum and cellular bud scar. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See DSE4 in Genome Data Viewer
    Location:
    chromosome: XIV
    Exon count:
    1
    Sequence:
    Chromosome: XIV; NC_001146.8 (755746..759099, complement)

    Chromosome XIV - NC_001146.8Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Bsc5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001146.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Characterization of the CaENG1 gene encoding an endo-1,3-beta-glucanase involved in cell separation in Candida albicans. Esteban PF, et al. Curr Microbiol, 2005 Dec. PMID 16328626
    2. Eng1p, an endo-1,3-beta-glucanase localized at the daughter side of the septum, is involved in cell separation in Saccharomyces cerevisiae. Baladrón V, et al. Eukaryot Cell, 2002 Oct. PMID 12455695, Free PMC Article
    3. GPI7 involved in glycosylphosphatidylinositol biosynthesis is essential for yeast cell separation. Fujita M, et al. J Biol Chem, 2004 Dec 10. PMID 15452134
    4. Cellular localization of Sun4p and its interaction with proteins in the yeast birth scar. Kuznetsov E, et al. Cell Cycle, 2016 Jul 17. PMID 27229769, Free PMC Article
    5. Disruption of LRG1 inhibits mother-daughter separation in Saccharomyces cerevisiae. Svarovsky MJ, et al. Yeast, 2005 Oct 30. PMID 16240460

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables glucan endo-1,3-beta-D-glucosidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables glucan endo-1,3-beta-D-glucosidase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables glucan endo-1,3-beta-glucanase activity, C-3 substituted reducing group IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucan endo-1,4-beta-glucanase activity, C-3 substituted reducing group IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glucosidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on glycosyl bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell wall organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in polysaccharide catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in septum digestion after cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell septum IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cellular bud neck HDA PubMed 
    located_in cellular bud scar IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in fungal-type cell wall IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    endo-1,3(4)-beta-glucanase
    NP_014465.1
    • Daughter cell-specific secreted protein with similarity to glucanases; degrades cell wall from the daughter side causing daughter to separate from mother

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001146.8 Reference assembly

      Range
      755746..759099 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001183244.1 → NP_014465.1  TPA: endo-1,3(4)-beta-glucanase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014465.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W1P2, P53753
      UniProtKB/TrEMBL
      A0A8H4F996, B5VR92, C7GM65
      Conserved Domains (1) summary
      COG5498
      Location:406 → 1117
      Acf2; Endoglucanase Acf2 [Carbohydrate transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53753.1

    Gene LinkOut

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