CIR2 putative electron-transferring-flavoprotein dehydrogenase [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: CIR2
Gene description: putative electron-transferring-flavoprotein dehydrogenase
Primary source: FungiDB:YOR356W
Locus tag: YOR356W
See related: SGD:S000005883; AllianceGenome:SGD:S000005883; VEuPathDB:YOR356W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Summary: Predicted to enable electron-transferring-flavoprotein dehydrogenase activity. Predicted to be involved in electron transport chain. Located in mitochondrion. Human ortholog(s) of this gene implicated in multiple acyl-CoA dehydrogenase deficiency. Orthologous to human ETFDH (electron transfer flavoprotein dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See CIR2 in Genome Data Viewer

Location:: chromosome: XV

Exon count:: 1

Sequence:: Chromosome: XV; NC_001147.6 (1007221..1009116)

Chromosome XV - NC_001147.6 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001147.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables electron-transferring-flavoprotein dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables electron-transferring-flavoprotein dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables molecular_function	ND No biological Data available more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in electron transport chain	IBA Inferred from Biological aspect of Ancestor more info
involved_in electron transport chain	IEA Inferred from Electronic Annotation more info
involved_in respiratory electron transport chain	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: putative electron-transferring-flavoprotein dehydrogenase

NP_015001.1

EC 1.5.5.1

Putative ortholog of human ETF-dH; found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response; ETF-dH is also known as electron transfer flavoprotein dehydrogenase

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001147.6 Reference assembly

Range

1007221..1009116

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183776.1 → NP_015001.1 TPA: putative electron-transferring-flavoprotein dehydrogenase [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_015001.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W351, Q08822

UniProtKB/TrEMBL

A0A6A5Q7C5, A6ZPI6, B3LK13, C7GNR2, C8ZHA6, G2WNL7, N1P3W1

Conserved Domains (3) summary

COG0644
Location:63 → 540

FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]

pfam05187
Location:523 → 629

ETF_QO; Electron transfer flavoprotein-ubiquinone oxidoreductase, 4Fe-4S

cl21454
Location:46 → 78

NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins