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    YME2 Yme2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855348, updated on 17-May-2024

    Summary

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    Gene symbol
    YME2
    Gene description
    Yme2p
    Primary source
    FungiDB:YMR302C
    Locus tag
    YMR302C
    See related
    SGD:S000004917; AllianceGenome:SGD:S000004917; VEuPathDB:YMR302C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    PRP12; RNA12
    Summary
    Predicted to enable RNA binding activity. Involved in mitochondrial genome maintenance. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YME2 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (870073..872625, complement)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene amidophosphoribosyltransferase Neighboring gene ATP-binding cassette Fe/S cluster precursor transporter ATM1 Neighboring gene alcohol dehydrogenase ADH2 Neighboring gene ubiquitin-specific protease UBP15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. rna12+, a gene of Saccharomyces cerevisiae involved in pre-rRNA maturation. Characterization of a temperature-sensitive mutant, cloning and sequencing of the gene. Liang S, et al. Mol Gen Genet, 1992 Mar. PMID 1557037
    2. Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae. Park S, et al. Curr Genet, 2006 Sep. PMID 16850347
    3. The ZbYME2 gene from the food spoilage yeast Zygosaccharomyces bailii confers not only YME2 functions in Saccharomyces cerevisiae, but also the capacity for catabolism of sorbate and benzoate, two major weak organic acid preservatives. Mollapour M, et al. Mol Microbiol, 2001 Nov. PMID 11737636
    4. Inactivation of YME2/RNA12, which encodes an integral inner mitochondrial membrane protein, causes increased escape of DNA from mitochondria to the nucleus in Saccharomyces cerevisiae. Hanekamp T, et al. Mol Cell Biol, 1996 Jun. PMID 8649384, Free PMC Article
    5. YNT20, a bypass suppressor of yme1 yme2, encodes a putative 3'-5' exonuclease localized in mitochondria of Saccharomyces cerevisiae. Hanekamp T, et al. Curr Genet, 1999 Jan. PMID 9933355

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery.
      Title: Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery.
    2. YME2 and its suppressors influence the structure and number of mitochondrial nucleoids
      Title: Yme2p is a mediator of nucleoid structure and number in mitochondria of the yeast Saccharomyces cerevisiae.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitochondrial genome maintenance IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mitochondrial genome maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrial inner membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 
    located_in mitochondrion IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Yme2p
    NP_014031.1
    • Integral inner mitochondrial membrane protein; role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      870073..872625 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182811.1 → NP_014031.1  TPA: Yme2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_014031.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W0C9, P32843
      UniProtKB/TrEMBL
      A0A6V8SA96, C7GTJ7, G2WL11
      Conserved Domains (2) summary
      pfam10443
      Location:364 → 814
      RNA12; RNA12 protein
      cd12433
      Location:194 → 276
      RRM_Yme2p_like; RNA recognition motif (RRM) found in yeast mitochondrial escape protein 2 (Yme2p) and similar proteins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32843.1

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