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    FUS1 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 850330, updated on 11-Sep-2024

    Summary

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    Official Symbol
    FUS1
    Primary source
    SGD:S000000532
    Locus tag
    YCL027W
    See related
    AllianceGenome:SGD:S000000532; FungiDB:YCL027W; VEuPathDB:YCL027W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Involved in cytogamy; maintenance of protein location in cell cortex; and regulation of termination of mating projection growth. Located in mating projection tip. Is integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: III
    Exon count:
    1
    Sequence:
    Chromosome: III; NC_001135.5 (71803..73341)

    Chromosome III - NC_001135.5Genomic Context describing neighboring genes Neighboring gene Bik1p Neighboring gene prion domain-containing protein RNQ1 Neighboring gene putative nitroreductase Neighboring gene type II nitroreductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001135.5

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. FUS1 regulates the opening and expansion of fusion pores between mating yeast. Nolan S, et al. Mol Biol Cell, 2006 May. PMID 16495338, Free PMC Article
    2. Yeast pheromone signaling pathway as a bioassay to assess the effect of chemicals on mammalian peptide hormones. Fujita K, et al. Ecotoxicol Environ Saf, 2003 Nov. PMID 14575675
    3. Identification and regulation of a gene required for cell fusion during mating of the yeast Saccharomyces cerevisiae. McCaffrey G, et al. Mol Cell Biol, 1987 Aug. PMID 3313002, Free PMC Article
    4. The yeast cell fusion protein FUS1 is O-glycosylated and spans the plasma membrane. Trueheart J, et al. Proc Natl Acad Sci U S A, 1989 Dec. PMID 2690078, Free PMC Article
    5. Quantitation of alpha-factor internalization and response during the Saccharomyces cerevisiae cell cycle. Zanolari B, et al. Mol Cell Biol, 1991 Oct. PMID 1656226, Free PMC Article

    See all (68) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results identify a sorting signal in the yeast cell fusion protein Fus1p that is required for its transport from the trans-Golgi compartment to the plasma membrane.
      Title: The exomer coat complex transports Fus1p to the plasma membrane via a novel plasma membrane sorting signal in yeast.
    2. dramatic alterations in SH3 domain of Fus1 specificity can be simply explained as a modulation of the binding strengths of these two surfaces.
      Title: Recognition of non-canonical peptides by the yeast Fus1p SH3 domain: elucidation of a common mechanism for diverse SH3 domain specificities.
    3. Fus1p localization to the tip of the mating projection is determined by its cytosolic domain, which binds to peripheral proteins involved in mating tip polarization.
      Title: Plasma membrane polarization during mating in yeast cells.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cytogamy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cytogamy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in maintenance of protein location in cell cortex IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum HDA PubMed 
    located_in mating projection tip HDA PubMed 
    located_in mating projection tip IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Fus1p
    NP_009903.2
    • Membrane protein localized to the shmoo tip; required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001135.5 Reference assembly

      Range
      71803..73341
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178672.1 → NP_009903.2  TPA: Fus1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009903.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQY8, P11710
      UniProtKB/TrEMBL
      A6ZTG3, B3LU55, B5VET1, C8Z461, G2W9Z8, N1P664
      Conserved Domains (1) summary
      cd11854
      Location:440 → 509
      SH3_Fus1p; Src homology 3 domain of yeast cell fusion protein Fus1p
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P11710.3

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