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    ADE1 phosphoribosylaminoimidazolesuccinocarboxamide synthase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851272, updated on 18-Sep-2024

    Summary

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    Official Symbol
    ADE1
    Official Full Name
    phosphoribosylaminoimidazolesuccinocarboxamide synthase
    Primary source
    SGD:S000000070
    Locus tag
    YAR015W
    See related
    AllianceGenome:SGD:S000000070; FungiDB:YAR015W; VEuPathDB:YAR015W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity. Involved in 'de novo' IMP biosynthetic process. Located in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human PAICS (phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See ADE1 in Genome Data Viewer
    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (169375..170295)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene tRNA-Ala Neighboring gene protein phosphatase regulator BUD14 Neighboring gene serine/threonine protein kinase KIN3 Neighboring gene serine/threonine protein kinase CDC15

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The structure of SAICAR synthase: an enzyme in the de novo pathway of purine nucleotide biosynthesis. Levdikov VM, et al. Structure, 1998 Mar 15. PMID 9551557
    2. Molecular cloning of the ADE1 gene of Saccharomyces cerevisiae and stability of the transformants. Dimock K, et al. Gene, 1984 Feb. PMID 6373504
    3. Enzymology of the pigmented adenine-requiring mutants of Saccharomyces and Schizosaccharomyces. Fisher CR. Biochem Biophys Res Commun, 1969 Feb 7. PMID 5767025
    4. [Cloning and physical mapping of the ADE1 gene of the yeast Saccharomyces cerevisiae]. Sasnauskas KV, et al. Genetika, 1986 Apr. PMID 3015720
    5. [Isolation and properties of phosphoribosyl-aminoimidazole-succinocarboxyamide-synthestase from Saccharomyces cerevisiae yeasts]. Ostanin KV, et al. Biokhimiia, 1989 Aug. PMID 2684279

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphoribosylaminoimidazolesuccinocarboxamide synthase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in 'de novo' IMP biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in 'de novo' IMP biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in 'de novo' IMP biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in purine nucleotide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in purine nucleotide biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    phosphoribosylaminoimidazolesuccinocarboxamide synthase
    NP_009409.1
    • N-succinyl-5-aminoimidazole-4-carboxamide ribotide synthetase; required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine; protein abundance increases in response to DNA replication stress

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      169375..170295
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178216.1 → NP_009409.1  TPA: phosphoribosylaminoimidazolesuccinocarboxamide synthase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009409.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPM4, P27616
      UniProtKB/TrEMBL
      A7A0H3, B3LUT3, B5VDM5, C7GUF6, C8Z3I5, G2W8N6, N1P7M3
      Conserved Domains (1) summary
      PRK13961
      Location:1 → 305
      PRK13961; phosphoribosylaminoimidazole-succinocarboxamide synthase; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P27616.2

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