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    RIB7 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852450, updated on 17-May-2024

    Summary

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    Gene symbol
    RIB7
    Gene description
    2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
    Primary source
    FungiDB:YBR153W
    Locus tag
    YBR153W
    See related
    SGD:S000000357; AllianceGenome:SGD:S000000357; VEuPathDB:YBR153W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity. Involved in riboflavin biosynthetic process. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See RIB7 in Genome Data Viewer
    Location:
    chromosome: II
    Exon count:
    1
    Sequence:
    Chromosome: II; NC_001134.8 (547460..548194)

    Chromosome II - NC_001134.8Genomic Context describing neighboring genes Neighboring gene Apd1p Neighboring gene U4/U6-U5 snRNP complex subunit SPP381 Neighboring gene DNA-directed RNA polymerase core subunit RPB5 Neighboring gene HSP70/90 family co-chaperone CNS1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001134.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional insights into Saccharomyces cerevisiae riboflavin biosynthesis reductase RIB7. Lv Z, et al. PLoS One, 2013. PMID 23620735, Free PMC Article
    2. Biosynthesis of riboflavin. Mutants accumulating 6-hydroxy-2,4,5-triaminopyrimidine. Bacher A, et al. FEBS Lett, 1969 Dec 30. PMID 11947306
    3. Mapping of the RIB1 and RIB7 genes involved in the biosynthesis of riboflavin in Saccharomyces cerevisiae. Buitrago MJ, et al. Yeast, 1993 Oct. PMID 8256517
    4. Biosynthesis of riboflavine in Saccharomyces cerevisiae: the role of genes rib 1 and rib 7 . Oltmanns O, et al. J Bacteriol, 1972 Jun. PMID 4555411, Free PMC Article
    5. Biosynthesis of riboflavin: characterization of the bifunctional deaminase-reductase of Escherichia coli and Bacillus subtilis. Richter G, et al. J Bacteriol, 1997 Mar. PMID 9068650, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables 5-amino-6-(5-phosphoribosylamino)uracil reductase activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in riboflavin biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in riboflavin biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase
    NP_009711.3
    • Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001134.8 Reference assembly

      Range
      547460..548194
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178501.3 → NP_009711.3  TPA: 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009711.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VQE8, P33312
      UniProtKB/TrEMBL
      A0A8H4BT75, G2W9F5, N1PAT9
      Conserved Domains (1) summary
      TIGR00227
      Location:28 → 241
      ribD_Cterm; riboflavin-specific deaminase C-terminal domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P33312.1

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