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    Celf5 CUGBP, Elav-like family member 5 [ Mus musculus (house mouse) ]

    Gene ID: 319586, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Celf5provided by MGI
    Official Full Name
    CUGBP, Elav-like family member 5provided by MGI
    Primary source
    MGI:MGI:2442333
    See related
    Ensembl:ENSMUSG00000034818 AllianceGenome:MGI:2442333
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Brunol5; 4930565A21Rik
    Summary
    Predicted to enable mRNA binding activity. Predicted to be involved in mRNA splice site selection and regulation of alternative mRNA splicing, via spliceosome. Predicted to be part of ribonucleoprotein complex. Predicted to be active in cytoplasm and nucleus. Is expressed in central nervous system; sensory organ; thymus; and tooth. Orthologous to human CELF5 (CUGBP Elav-like family member 5). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E18 (RPKM 40.2), whole brain E14.5 (RPKM 38.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Celf5 in Genome Data Viewer
    Location:
    10 C1; 10 39.72 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (81295061..81318564, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (81459227..81482730, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene nuclear factor I/C Neighboring gene predicted gene, 53593 Neighboring gene predicted gene, 51811 Neighboring gene STARR-positive B cell enhancer ABC_E577 Neighboring gene STARR-seq mESC enhancer starr_27338 Neighboring gene STARR-positive B cell enhancer ABC_E8350 Neighboring gene nicalin Neighboring gene sphingosine-1-phosphate receptor 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A genome-wide in situ hybridization map of RNA-binding proteins reveals anatomically restricted expression in the developing mouse brain. McKee AE, et al. BMC Dev Biol, 2005 Jul 20. PMID 16033648, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in mRNA splice site recognition IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of ribonucleoprotein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    CUGBP Elav-like family member 5
    Names
    bruno-like 5, RNA binding protein

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001311124.2 → NP_001298053.1  CUGBP Elav-like family member 5 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) use an alternate in-frame splice site in the 5' coding region compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS78869.1
      UniProtKB/TrEMBL
      D3Z580
      Related
      ENSMUSP00000113592.2, ENSMUST00000120508.8
      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 355
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:94 → 174
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    2. NM_001311126.2 → NP_001298055.1  CUGBP Elav-like family member 5 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5'UTR and lacks exons in the 5' coding region and uses an alternate splice site in the 5' coding region compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS78868.1
      UniProtKB/TrEMBL
      D3Z4C5
      Related
      ENSMUSP00000113784.2, ENSMUST00000120856.8
      Conserved Domains (2) summary
      TIGR01628
      Location:21 → 279
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:18 → 98
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    3. NM_001311127.2 → NP_001298056.1  CUGBP Elav-like family member 5 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks exon in the 5' coding region which results in the use of a downstream start codon compared to variant 1. The encoded isoform (4) has a shorter N-terminus compared to isoform 1.
      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS78867.1
      UniProtKB/TrEMBL
      D3Z588
      Related
      ENSMUSP00000113546.2, ENSMUST00000119060.8
      Conserved Domains (2) summary
      TIGR01628
      Location:22 → 280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:19 → 99
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    4. NM_001374703.1 → NP_001361632.1  CUGBP Elav-like family member 5 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS88058.1
      UniProtKB/TrEMBL
      A0A5F8MPH2
      Related
      ENSMUSP00000158971.2, ENSMUST00000238823.2
      Conserved Domains (4) summary
      TIGR01628
      Location:9 → 358
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:95 → 175
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:357 → 435
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    5. NM_001379187.1 → NP_001366116.1  CUGBP Elav-like family member 5 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 363
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:95 → 175
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    6. NM_001379188.1 → NP_001366117.1  CUGBP Elav-like family member 5 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 362
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 (RRM1) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:94 → 174
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    7. NM_001379189.1 → NP_001366118.1  CUGBP Elav-like family member 5 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (3) summary
      cd12639
      Location:287 → 365
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:11 → 367
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:25 → 105
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    8. NM_001379190.1 → NP_001366119.1  CUGBP Elav-like family member 5 isoform 9

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (3) summary
      cd12639
      Location:281 → 359
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:5 → 361
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:19 → 99
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    9. NM_001379191.1 → NP_001366120.1  CUGBP Elav-like family member 5 isoform 10

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:55 → 313
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:52 → 132
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    10. NM_001379192.1 → NP_001366121.1  CUGBP Elav-like family member 5 isoform 11

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:56 → 321
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:53 → 133
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    11. NM_001379193.1 → NP_001366122.1  CUGBP Elav-like family member 5 isoform 12

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:55 → 320
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:52 → 132
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    12. NM_001379194.1 → NP_001366123.1  CUGBP Elav-like family member 5 isoform 13

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:27 → 285
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:24 → 104
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    13. NM_001379195.1 → NP_001366124.1  CUGBP Elav-like family member 5 isoform 14

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:28 → 293
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:25 → 105
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    14. NM_001379196.1 → NP_001366125.1  CUGBP Elav-like family member 5 isoform 15

      Status: VALIDATED

      Source sequence(s)
      AC159474
      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 255
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:1 → 74
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    15. NM_001379197.1 → NP_001366126.1  CUGBP Elav-like family member 5 isoform 16

      Status: VALIDATED

      Source sequence(s)
      AC159474
      UniProtKB/TrEMBL
      Q8BJL3
      Related
      ENSMUST00000141207.8
      Conserved Domains (1) summary
      cd12635
      Location:24 → 104
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    16. NM_176954.4 → NP_795928.2  CUGBP Elav-like family member 5 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes isoform 1.
      Source sequence(s)
      AC159474
      Consensus CDS
      CCDS48644.1
      UniProtKB/TrEMBL
      D3Z4T1
      Related
      ENSMUSP00000113675.2, ENSMUST00000118763.8
      Conserved Domains (3) summary
      TIGR01628
      Location:9 → 356
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:95 → 175
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      81295061..81318564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513743.4 → XP_006513806.1  CUGBP Elav-like family member 5 isoform X1

      Conserved Domains (4) summary
      TIGR01628
      Location:9 → 357
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12632
      Location:2 → 88
      RRM1_CELF3_4_5_6; RNA recognition motif 1 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12635
      Location:94 → 174
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:356 → 434
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    2. XM_036155811.1 → XP_036011704.1  CUGBP Elav-like family member 5 isoform X6

      Conserved Domains (3) summary
      cd12639
      Location:256 → 334
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:2 → 336
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:1 → 74
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    3. XM_036155813.1 → XP_036011706.1  CUGBP Elav-like family member 5 isoform X8

      Conserved Domains (2) summary
      TIGR01628
      Location:8 → 255
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:1 → 74
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    4. XM_036155812.1 → XP_036011705.1  CUGBP Elav-like family member 5 isoform X7

      UniProtKB/TrEMBL
      D3Z588
      Conserved Domains (2) summary
      TIGR01628
      Location:22 → 280
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:19 → 99
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    5. XM_030245117.2 → XP_030100977.2  CUGBP Elav-like family member 5 isoform X3

      Conserved Domains (3) summary
      cd12639
      Location:314 → 392
      RRM3_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:42 → 394
      ELAV_HUD_SF; ELAV/HuD family splicing factor
      cd12635
      Location:52 → 132
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    6. XM_036155810.1 → XP_036011703.1  CUGBP Elav-like family member 5 isoform X5

      Conserved Domains (2) summary
      TIGR01628
      Location:56 → 314
      PABP-1234; polyadenylate binding protein, human types 1, 2, 3, 4 family
      cd12635
      Location:53 → 133
      RRM2_CELF3_4_5_6; RNA recognition motif 2 (RRM2) found in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins

    7. XM_006513744.5 → XP_006513807.1  CUGBP Elav-like family member 5 isoform X2

      Conserved Domains (3) summary
      cd12635
      Location:53 → 133
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:315 → 393
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:39 → 395
      ELAV_HUD_SF; ELAV/HuD family splicing factor

    8. XM_006513748.4 → XP_006513811.1  CUGBP Elav-like family member 5 isoform X4

      Conserved Domains (3) summary
      cd12635
      Location:24 → 104
      RRM2_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      cd12639
      Location:286 → 364
      RRM3_CELF3_4_5_6; RNA recognition motif 2 in CUGBP Elav-like family member CELF-3, CELF-4, CELF-5, CELF-6 and similar proteins
      TIGR01661
      Location:14 → 366
      ELAV_HUD_SF; ELAV/HuD family splicing factor
    Nucleotide Protein Strain
    Heading Accession and Version

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