ACC1 acetyl-CoA carboxylase ACC1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: ACC1
Gene description: acetyl-CoA carboxylase ACC1
Primary source: FungiDB:YNR016C
Locus tag: YNR016C
See related: SGD:S000005299; AllianceGenome:SGD:S000005299; VEuPathDB:YNR016C
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: ABP2; FAS3; MTR7
Summary: Enables acetyl-CoA carboxylase activity and biotin carboxylase activity. Involved in long-chain fatty acid biosynthetic process and protein import into nucleus. Located in endoplasmic reticulum membrane. Orthologous to several human genes including ACACA (acetyl-CoA carboxylase alpha). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See ACC1 in Genome Data Viewer

Location:: chromosome: XIV

Exon count:: 1

Sequence:: Chromosome: XIV; NC_001146.8 (654673..661374, complement)

Chromosome XIV - NC_001146.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001146.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
Title: Fine-tuning acetyl-CoA carboxylase 1 activity through localization: functional genomics reveals a role for the lysine acetyltransferase NuA4 and sphingolipid metabolism in regulating Acc1 activity and localization.
Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast.
Title: Shortening of membrane lipid acyl chains compensates for phosphatidylcholine deficiency in choline-auxotroph yeast.
Regulation of autophagy by Acc1 depends on a combination of metabolic consequences that involve alterations in both acetate (upstream of Acc1) and lipid (downstream of Acc1) metabolism.
Title: Acetyl-CoA carboxylase 1-dependent lipogenesis promotes autophagy downstream of AMPK.
urther our work suggests that NuA4 regulates acetyl-CoA levels through the Acetyl-CoA carboxylase Acc1. Altogether this work establishes both NuA4 and the metabolite acetyl-CoA as critical signaling pathways regulating the formation of glucose-deprived stress granules.
Title: Lysine acetyltransferase NuA4 and acetyl-CoA regulate glucose-deprived stress granule formation in Saccharomyces cerevisiae.
Overexpression of FAS1, FAS2 and Acc1 leads to accumulation of sterols.
Title: Overexpression of genes of the fatty acid biosynthetic pathway leads to accumulation of sterols in Saccharomyces cerevisiae.
Data show that attenuated expression of acetyl-CoA carboxylase ACC1 results in increased acetylation of bulk histones, globally increased acetylation of chromatin histones, and altered transcriptional regulation.
Title: Acetyl-CoA carboxylase regulates global histone acetylation.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables acetyl-CoA carboxylase activity	IEA Inferred from Electronic Annotation more info
enables acetyl-CoA carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables biotin carboxylase activity	IEA Inferred from Electronic Annotation more info
enables biotin carboxylase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ligase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in long-chain fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in malonyl-CoA biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	HDA more info	PubMed
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: acetyl-CoA carboxylase ACC1

NP_014413.1

EC 6.3.4.14

EC 6.4.1.2

Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availability of acetyl-CoA; rate-limiting step for de novo biosynthesis of long-chain fatty acids; translational regulation in response to nutrients and cell cycle stage depends on its upstream ORF; ACC1 has a paralog, HFA1, that arose from the whole genome duplication

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001146.8 Reference assembly

Range

654673..661374 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001183193.1 → NP_014413.1 TPA: acetyl-CoA carboxylase ACC1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_014413.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6W1J1, Q00955

UniProtKB/TrEMBL

A0A8H4BVX0, A6ZS90, B3LPM6, C7GLN9, N1P4Q3

Conserved Domains (4) summary

COG0439
Location:59 → 570

AccC; Biotin carboxylase [Lipid transport and metabolism]

COG0511
Location:622 → 769

AccB; Biotin carboxyl carrier protein [Coenzyme transport and metabolism, Lipid transport and metabolism]

pfam01039
Location:1574 → 2118

Carboxyl_trans; Carboxyl transferase domain

pfam08326
Location:768 → 1479

ACC_central; Acetyl-CoA carboxylase, central region