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    MET3 sulfate adenylyltransferase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853466, updated on 17-May-2024

    Summary

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    Gene symbol
    MET3
    Gene description
    sulfate adenylyltransferase
    Primary source
    FungiDB:YJR010W
    Locus tag
    YJR010W
    See related
    SGD:S000003771; AllianceGenome:SGD:S000003771; VEuPathDB:YJR010W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables sulfate adenylyltransferase (ATP) activity. Involved in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) and sulfur amino acid metabolic process. Located in mitochondrion. Human ortholog(s) of this gene implicated in spondyloepimetaphyseal dysplasia, Pakistani type. Orthologous to human PAPSS1 (3'-phosphoadenosine 5'-phosphosulfate synthase 1) and PAPSS2 (3'-phosphoadenosine 5'-phosphosulfate synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See MET3 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (456239..457774)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene Mho1p Neighboring gene glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) TDH2 Neighboring gene signal peptidase complex subunit SPC1 Neighboring gene Cal4p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and functional analysis of a truncated form of Saccharomyces cerevisiae ATP sulfurylase: C-terminal domain essential for oligomer formation but not for activity. Lalor DJ, et al. Protein Eng, 2003 Dec. PMID 14983089
    2. Molecular and genetic analysis of the Cryptococcus neoformans MET3 gene and a met3 mutant. Yang Z, et al. Microbiology (Reading), 2002 Aug. PMID 12177356
    3. Crystal structure of ATP sulfurylase from Saccharomyces cerevisiae, a key enzyme in sulfate activation. Ullrich TC, et al. EMBO J, 2001 Feb 1. PMID 11157739, Free PMC Article
    4. Production, purification, and luminometric analysis of recombinant Saccharomyces cerevisiae MET3 adenosine triphosphate sulfurylase expressed in Escherichia coli. Karamohamed S, et al. Protein Expr Purif, 1999 Apr. PMID 10092498
    5. Genetic and regulatory aspects of methionine biosynthesis in Saccharomyces cerevisiae. Cherest H, et al. J Bacteriol, 1969 Jan. PMID 5764336, Free PMC Article

    See all (56) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nucleotidyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables sulfate adenylyltransferase (ATP) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables sulfate adenylyltransferase (ATP) activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in hydrogen sulfide biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfate assimilation via adenylyl sulfate reduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur amino acid metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in sulfur amino acid metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sulfur compound metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in mitochondrion HDA PubMed 

    General protein information

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    Preferred Names
    sulfate adenylyltransferase
    NP_012543.3
    • ATP sulfurylase; catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism; human homolog PAPSS2 complements yeast null mutant

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      456239..457774
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181668.3 → NP_012543.3  TPA: sulfate adenylyltransferase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012543.3

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VWI5, P08536, Q66R66
      UniProtKB/TrEMBL
      A0A6A5PYL9, A6ZPX7, B3LQA9, C7GWK0, D3UF76, N1P8M1
      Conserved Domains (1) summary
      TIGR00339
      Location:4 → 386
      sopT; ATP sulphurylase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08536.2

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