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    PEX2 ubiquitin-protein ligase peroxin 2 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853219, updated on 18-Sep-2024

    Summary

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    Official Symbol
    PEX2
    Official Full Name
    ubiquitin-protein ligase peroxin 2
    Primary source
    SGD:S000003746
    Locus tag
    YJL210W
    See related
    AllianceGenome:SGD:S000003746; FungiDB:YJL210W; VEuPathDB:YJL210W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    CRT1; PAS5
    Summary
    Enables ubiquitin protein ligase activity. Involved in protein import into peroxisome matrix and protein polyubiquitination. Located in peroxisomal membrane. Part of peroxisomal importomer complex. Human ortholog(s) of this gene implicated in peroxisomal biogenesis disorder and peroxisome biogenesis disorder 5A. Orthologous to human PEX2 (peroxisomal biogenesis factor 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PEX2 in Genome Data Viewer
    Location:
    chromosome: X
    Exon count:
    1
    Sequence:
    Chromosome: X; NC_001142.9 (36919..37734)

    Chromosome X - NC_001142.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene oligopeptide transporter OPT1 Neighboring gene Cbp1p Neighboring gene ribonuclease

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001142.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Independent regulation of full-length and 5'-truncated PAS5 mRNAs in Saccharomyces cerevisiae. Liu Y, et al. Yeast, 1996 Feb. PMID 8686377
    2. Peroxisome remnants in pex3delta cells and the requirement of Pex3p for interactions between the peroxisomal docking and translocation subcomplexes. Hazra PP, et al. Traffic, 2002 Aug. PMID 12121419
    3. dNTP pool levels modulate mutator phenotypes of error-prone DNA polymerase ε variants. Williams LN, et al. Proc Natl Acad Sci U S A, 2015 May 12. PMID 25827226, Free PMC Article
    4. The RING-type ubiquitin ligases Pex2p, Pex10p and Pex12p form a heteromeric complex that displays enhanced activity in an ubiquitin conjugating enzyme-selective manner. El Magraoui F, et al. FEBS J, 2012 Jun. PMID 22471590
    5. Distinct ubiquitination cascades act on the peroxisomal targeting signal type 2 co-receptor Pex18p. El Magraoui F, et al. Traffic, 2013 Dec. PMID 24034674

    See all (41) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in protein import into peroxisome matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, receptor recycling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein import into peroxisome matrix, receptor recycling IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein import into peroxisome matrix, substrate release IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein monoubiquitination IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of peroxisomal importomer complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in peroxisomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in peroxisome IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    ubiquitin-protein ligase peroxin 2
    NP_012325.1
    • RING-finger peroxin and E3 ubiquitin ligase; peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001142.9 Reference assembly

      Range
      36919..37734
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001181643.1 → NP_012325.1  TPA: ubiquitin-protein ligase peroxin 2 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012325.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVY4, P32800
      UniProtKB/TrEMBL
      A6ZQC9, B3LPS0, B5VKY0, C7GUE4, G2WGH0, N1P1K5
      Conserved Domains (2) summary
      pfam04757
      Location:13 → 212
      Pex2_Pex12; Pex2 / Pex12 amino terminal region
      cl17238
      Location:221 → 247
      RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P32800.1

    Gene LinkOut

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