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    PHO11 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851299, updated on 11-Sep-2024

    Summary

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    Official Symbol
    PHO11
    Primary source
    SGD:S000000094
    Locus tag
    YAR071W
    See related
    AllianceGenome:SGD:S000000094; FungiDB:YAR071W; VEuPathDB:YAR071W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables acid phosphatase activity. Predicted to be involved in phosphate-containing compound metabolic process. Located in extracellular region. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia and thyroid gland papillary carcinoma. Orthologous to human MINPP1 (multiple inositol-polyphosphate phosphatase 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (225460..226863)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The role of core-oligosaccharide in formation of an active acid phosphatase and its secretion by yeast protoplasts. Mizunaga T, et al. J Biochem, 1982 Jan. PMID 6802810
    2. Role of the carbohydrate part of yeast acid phosphatase. Barbarić S, et al. Arch Biochem Biophys, 1984 Nov 1. PMID 6437332
    3. Physicochemical and kinetic properties of acid phosphatase from Saccharomyces cerevisiae. Barbarić S, et al. J Biol Chem, 1984 Jan 25. PMID 6363410
    4. Role of glycosylation in secretion of yeast acid phosphatase. Mrsa V, et al. FEBS Lett, 1987 Jun 15. PMID 3297779
    5. The yeast PHO5 promoter: phosphate-control elements and sequences mediating mRNA start-site selection. Rudolph H, et al. Proc Natl Acad Sci U S A, 1987 Mar. PMID 2881299, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables acid phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables acid phosphatase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables acid phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in phosphate-containing compound metabolic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cell periphery HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in fungal-type cell wall IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    acid phosphatase PHO11
    NP_009434.1
    • One of three repressible acid phosphatases; glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2; PHO11 has a paralog, PHO12, that arose from a segmental duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      225460..226863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178239.1 → NP_009434.1  TPA: acid phosphatase PHO11 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009434.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPP1, P35842
      UniProtKB/TrEMBL
      A6ZSK2, B5VKE4
      Conserved Domains (1) summary
      pfam00328
      Location:65 → 399
      His_Phos_2; Histidine phosphatase superfamily (branch 2)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P35842.1

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