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    PRP45 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 851201, updated on 11-Sep-2024

    Summary

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    Official Symbol
    PRP45
    Primary source
    SGD:S000000030
    Locus tag
    YAL032C
    See related
    AllianceGenome:SGD:S000000030; FungiDB:YAL032C; VEuPathDB:YAL032C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    FUN20
    Summary
    Predicted to contribute to first spliceosomal transesterification activity and second spliceosomal transesterification activity. Involved in generation of catalytic spliceosome for second transesterification step. Located in nucleus. Part of U2-type catalytic step 1 spliceosome; U2-type catalytic step 2 spliceosome; and post-mRNA release spliceosomal complex. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: I
    Exon count:
    1
    Sequence:
    Chromosome: I; NC_001133.9 (83335..84474, complement)

    Chromosome I - NC_001133.9Genomic Context describing neighboring genes Neighboring gene Fun19p Neighboring gene RNA-binding protein POP5 Neighboring gene protein phosphatase regulator GIP4 Neighboring gene SNAP receptor SNC1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001133.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Nineteen complex-related factor Prp45 is required for the early stages of cotranscriptional spliceosome assembly. Hálová M, et al. RNA, 2017 Oct. PMID 28701519, Free PMC Article
    2. Functional mapping of Saccharomyces cerevisiae Prp45 identifies the SNW domain as essential for viability. Martinkova K, et al. J Biochem, 2002 Oct. PMID 12359070
    3. H3K36 Methylation and the Chromodomain Protein Eaf3 Are Required for Proper Cotranscriptional Spliceosome Assembly. Leung CS, et al. Cell Rep, 2019 Jun 25. PMID 31242410, Free PMC Article
    4. The human Ski-interacting protein functionally substitutes for the yeast PRP45 gene. Figueroa JD, et al. Biochem Biophys Res Commun, 2004 Jul 9. PMID 15194481
    5. The fission yeast ortholog of the coregulator SKIP interacts with the small subunit of U2AF. Ambrozková M, et al. Biochem Biophys Res Commun, 2001 Jun 29. PMID 11414703

    See all (51) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Prp45 facilitates conformational rearrangements and/or contacts that couple U1 snRNP-recognition to the early stages of cotranscriptional spliceosome assembly.
      Title: Nineteen complex-related factor Prp45 is required for the early stages of cotranscriptional spliceosome assembly.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    contributes_to first spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    contributes_to second spliceosomal transesterification activity IC
    Inferred by Curator
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in generation of catalytic spliceosome for second transesterification step IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in generation of catalytic spliceosome for second transesterification step IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of U2-type catalytic step 1 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of U2-type catalytic step 2 spliceosome IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of post-mRNA release spliceosomal complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mRNA splicing protein PRP45
    NP_009370.1
    • Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001133.9 Reference assembly

      Range
      83335..84474 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001178177.1 → NP_009370.1  TPA: mRNA splicing protein PRP45 [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_009370.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VPI6, P28004
      UniProtKB/TrEMBL
      B3LUW6, B5VDI9, C7GPK3, C8Z3G9, N1PAY8
      Conserved Domains (1) summary
      pfam02731
      Location:112 → 249
      SKIP_SNW; SKIP/SNW domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P28004.2

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