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    SIP18 Sip18p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 855213, updated on 1-Aug-2024

    Summary

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    Gene symbol
    SIP18
    Gene description
    Sip18p
    Primary source
    FungiDB:YMR175W
    Locus tag
    YMR175W
    See related
    SGD:S000004787; AllianceGenome:SGD:S000004787; VEuPathDB:YMR175W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables phospholipid binding activity. Involved in cellular response to water deprivation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See SIP18 in Genome Data Viewer
    Location:
    chromosome: XIII
    Exon count:
    1
    Sequence:
    Chromosome: XIII; NC_001145.3 (611016..611255)

    Chromosome XIII - NC_001145.3Genomic Context describing neighboring genes Neighboring gene DNA damage-responsive protein 48 Neighboring gene Pai3p Neighboring gene uncharacterized protein Neighboring gene Ecm5p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001145.3

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Genetic improvement of Saccharomyces cerevisiae wine strains for enhancing cell viability after desiccation stress. López-Martínez G, et al. Yeast, 2013 Aug. PMID 23576041
    2. Role of paired basic residues of protein C-termini in phospholipid binding. Scheglmann D, et al. Protein Eng, 2002 Jun. PMID 12082171
    3. Studies on the Proteinaceous Structure Present on the Surface of the Saccharomyces cerevisiae Spore Wall. Yang Y, et al. J Fungi (Basel), 2023 Mar 23. PMID 37108847, Free PMC Article
    4. Determination of Proteinaceous Selenocysteine in Selenized Yeast. Bierla K, et al. Int J Mol Sci, 2018 Feb 11. PMID 29439473, Free PMC Article
    5. Expression of GPD1 and SIP18 genes during rehydration in active dry industrial Saccharomyces cerevisiae cider-making yeast strains (ADY). Goncerzewicz A, et al. Acta Biochim Pol, 2017. PMID 28600909

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. High expression of SIP18 at the beginning of rehydration was shown to be due to high transcription of the gene during the drying process.
      Title: Expression of GPD1 and SIP18 genes during rehydration in active dry industrial Saccharomyces cerevisiae cider-making yeast strains (ADY).
    2. SIP18p acts as an inhibitor of apoptosis in yeast under dehydration stress, suggested by its antioxidative capacity through the reduction of ROS accumulation after an H2O2 attack.
      Title: Sip18 hydrophilin prevents yeast cell death during desiccation stress.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables phospholipid binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in cellular response to water deprivation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Sip18p
    NP_013900.1
    • Phospholipid-binding hydrophilin; essential to overcome desiccation-rehydration process; expression is induced by osmotic stress; SIP18 has a paralog, GRE1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001145.3 Reference assembly

      Range
      611016..611255
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001182681.1 → NP_013900.1  TPA: Sip18p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_013900.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VZZ7, P50263
      UniProtKB/TrEMBL
      A6ZMN4, B3LM61, C7GTS6, C8ZF37, G2WKM8, N1NYI8
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P50263.1

    Gene LinkOut

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