SOR1 L-iditol 2-dehydrogenase SOR1 [Saccharomyces cerevisiae S288C] - Gene

Summary

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Gene symbol: SOR1
Gene description: L-iditol 2-dehydrogenase SOR1
Primary source: FungiDB:YJR159W
Locus tag: YJR159W
See related: SGD:S000003920; AllianceGenome:SGD:S000003920; VEuPathDB:YJR159W
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Saccharomyces cerevisiae S288C (strain: S288C)
Lineage: Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as: SDH1
Summary: Enables L-iditol 2-dehydrogenase activity. Involved in hexose metabolic process. Orthologous to human SORD (sorbitol dehydrogenase). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See SOR1 in Genome Data Viewer

Location:: chromosome: X

Exon count:: 1

Sequence:: Chromosome: X; NC_001142.9 (736044..737117)

Chromosome X - NC_001142.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_001142.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Gene Ontology Provided by SGD

Function	Evidence Code	Pubs
enables D-xylulose reductase activity	IEA Inferred from Electronic Annotation more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables L-iditol 2-dehydrogenase (NAD+) activity	IDA Inferred from Direct Assay more info	PubMed
enables L-iditol 2-dehydrogenase (NAD+) activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables L-iditol 2-dehydrogenase (NAD+) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	RCA inferred from Reviewed Computational Analysis more info	PubMed

Process	Evidence Code	Pubs
involved_in hexose metabolic process	IEP Inferred from Expression Pattern more info	PubMed
involved_in sorbitol catabolic process	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: L-iditol 2-dehydrogenase SOR1

NP_012693.1

EC 1.1.1.9

Sorbitol dehydrogenase; protein sequence is 99% identical to the Sor2p sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001142.9 Reference assembly

Range

736044..737117

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001181817.1 → NP_012693.1 TPA: L-iditol 2-dehydrogenase SOR1 [Saccharomyces cerevisiae S288C]

See identical proteins and their annotated locations for NP_012693.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D6VWX7, P35497

UniProtKB/TrEMBL

A6ZX89, B3LHC1, B5VF37, C8Z6M7

Conserved Domains (1) summary

cd05285
Location:8 → 353

sorbitol_DH; Sorbitol dehydrogenase