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    YGK1 5'-deoxynucleotidase [ Saccharomyces cerevisiae S288C ]

    Gene ID: 852777, updated on 1-Aug-2024

    Summary

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    Gene symbol
    YGK1
    Gene description
    5'-deoxynucleotidase
    Primary source
    FungiDB:YGL101W
    Locus tag
    YGL101W
    See related
    SGD:S000003069; AllianceGenome:SGD:S000003069; VEuPathDB:YGL101W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables 5'-deoxynucleotidase activity and GMP 5'-nucleotidase activity. Involved in deoxyribonucleoside monophosphate catabolic process. Located in cytoplasm and nucleus. Orthologous to human HDDC2 (HD domain containing 2). [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See YGK1 in Genome Data Viewer
    Location:
    chromosome: VII
    Exon count:
    1
    Sequence:
    Chromosome: VII; NC_001139.9 (312193..312840)

    Chromosome VII - NC_001139.9Genomic Context describing neighboring genes Neighboring gene putative sugar transporter Neighboring gene ribosomal 60S subunit protein L28 Neighboring gene Seh1p Neighboring gene putative GTPase LSG1

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001139.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Structural and biochemical characterization of the yeast HD domain containing protein YGK1 reveals a metal-dependent nucleoside 5'-monophosphatase. Yang J, et al. Biochem Biophys Res Commun, 2018 Jun 27. PMID 29752939
    2. Disruption and phenotypic analysis of six open reading frames from the left arm of Saccharomyces cerevisiae chromosome VII. Lillo JA, et al. Yeast, 2000 Mar 15. PMID 10669874
    3. Srs2 and Sgs1 DNA helicases associate with Mre11 in different subcomplexes following checkpoint activation and CDK1-mediated Srs2 phosphorylation. Chiolo I, et al. Mol Cell Biol, 2005 Jul. PMID 15964827, Free PMC Article
    4. Complex mutation profiles in mismatch repair and ribonucleotide reductase mutants reveal novel repair substrate specificity of MutS homolog (MSH) complexes. Lamb NA, et al. Genetics, 2022 Jul 30. PMID 35686905, Free PMC Article
    5. The nucleotide sequence of Saccharomyces cerevisiae chromosome VII. Tettelin H, et al. Nature, 1997 May 29. PMID 9169869

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables 5'-deoxynucleotidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5'-deoxynucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables 5'-deoxynucleotidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GMP 5'-nucleotidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in deoxyribonucleoside monophosphate catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    located_in nucleus HDA PubMed 

    General protein information

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    Preferred Names
    5'-deoxynucleotidase
    NP_011414.1
    • 5'-deoxynucleotidase; non-essential gene involved in deoxyribonucleoside monophosphate degradation; interacts with the DNA helicase Hpr5p; YGL101W has a paralog, YBR242W, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001139.9 Reference assembly

      Range
      312193..312840
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001180966.1 → NP_011414.1  TPA: 5'-deoxynucleotidase [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_011414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VU44, P53144
      UniProtKB/TrEMBL
      A6ZU79, B3LHG6, B5VIM4, C7GM19, C8Z8E7, G2WDZ8, N1P9P6
      Conserved Domains (1) summary
      COG1896
      Location:25 → 210
      YfbR; 5'-deoxynucleotidase YfbR and related HD superfamily hydrolases [Nucleotide transport and metabolism, General function prediction only]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P53144.1

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