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    EMC5 [ Saccharomyces cerevisiae S288C ]

    Gene ID: 854785, updated on 11-Sep-2024

    Summary

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    Official Symbol
    EMC5
    Primary source
    SGD:S000001289
    Locus tag
    YIL027C
    See related
    AllianceGenome:SGD:S000001289; FungiDB:YIL027C; VEuPathDB:YIL027C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Also known as
    KRE27
    Summary
    Involved in protein folding in endoplasmic reticulum. Located in endoplasmic reticulum. Part of EMC complex. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    Location:
    chromosome: IX
    Exon count:
    1
    Sequence:
    Chromosome: IX; NC_001141.2 (303679..304104, complement)

    Chromosome IX - NC_001141.2Genomic Context describing neighboring genes Neighboring gene tRNA-Lys Neighboring gene Ema17p Neighboring gene Irr1p Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001141.2

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A conserved endoplasmic reticulum membrane protein complex (EMC) facilitates phospholipid transfer from the ER to mitochondria. Lahiri S, et al. PLoS Biol, 2014 Oct. PMID 25313861, Free PMC Article
    2. Structure of the ER membrane complex, a transmembrane-domain insertase. Bai L, et al. Nature, 2020 Aug. PMID 32494008, Free PMC Article
    3. Biosynthesis of ionotropic acetylcholine receptors requires the evolutionarily conserved ER membrane complex. Richard M, et al. Proc Natl Acad Sci U S A, 2013 Mar 12. PMID 23431131, Free PMC Article
    4. A Saccharomyces cerevisiae genome-wide mutant screen for altered sensitivity to K1 killer toxin. Pagé N, et al. Genetics, 2003 Mar. PMID 12663529, Free PMC Article
    5. Evidence for interaction between Hsp90 and the ER membrane complex. Kudze T, et al. Cell Stress Chaperones, 2018 Sep. PMID 29808299, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein folding in endoplasmic reticulum HGI PubMed 
    Component Evidence Code Pubs
    part_of EMC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of EMC complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in endoplasmic reticulum HDA PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in endoplasmic reticulum membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Emc5p
    NP_012237.1
    • Member of conserved ER transmembrane complex; required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance; homologous to worm B0334.15/EMC-5, fly CG15168, human MMGT

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001141.2 Reference assembly

      Range
      303679..304104 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179377.1 → NP_012237.1  TPA: Emc5p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012237.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VVQ3, P40540
      UniProtKB/TrEMBL
      A6ZVP1, B3LTN4, C7GPX4, C8ZAM1, G2WGB8, N1P459
      Conserved Domains (1) summary
      pfam10270
      Location:9 → 129
      MMgT; Membrane magnesium transporter
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P40540.1

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