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    OSI1 Osi1p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 853792, updated on 17-May-2024

    Summary

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    Gene symbol
    OSI1
    Gene description
    Osi1p
    Primary source
    FungiDB:YKL071W
    Locus tag
    YKL071W
    See related
    SGD:S000001554; AllianceGenome:SGD:S000001554; VEuPathDB:YKL071W
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables alcohol dehydrogenase (NAD+) activity. Involved in cellular detoxification of aldehyde. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See OSI1 in Genome Data Viewer
    Location:
    chromosome: XI
    Exon count:
    1
    Sequence:
    Chromosome: XI; NC_001143.9 (305114..305884)

    Chromosome XI - NC_001143.9Genomic Context describing neighboring genes Neighboring gene Stb6p Neighboring gene tRNA-Trp Neighboring gene uncharacterized protein Neighboring gene L-methionine (R)-S-oxide reductase

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001143.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Resistance of Saccharomyces cerevisiae to high concentrations of furfural is based on NADPH-dependent reduction by at least two oxireductases. Heer D, et al. Appl Environ Microbiol, 2009 Dec. PMID 19854918, Free PMC Article
    2. Yap1p, the central regulator of the S. cerevisiae oxidative stress response, is activated by allicin, a natural oxidant and defence substance of garlic. Gruhlke MCH, et al. Free Radic Biol Med, 2017 Jul. PMID 28479370
    3. Activation of heat shock and antioxidant responses by the natural product celastrol: transcriptional signatures of a thiol-targeted molecule. Trott A, et al. Mol Biol Cell, 2008 Mar. PMID 18199679, Free PMC Article
    4. YKL071W from Saccharomyces cerevisiae encodes a novel aldehyde reductase for detoxification of glycolaldehyde and furfural derived from lignocellulose. Wang H, et al. Appl Microbiol Biotechnol, 2017 Dec. PMID 29034432
    5. Mechanisms of patulin toxicity under conditions that inhibit yeast growth. Iwahashi Y, et al. J Agric Food Chem, 2006 Mar 8. PMID 16506856

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables aldehyde dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables oxidoreductase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables oxidoreductase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular detoxification of aldehyde IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Osi1p
    NP_012852.1
    • NADH-dependent short-chain aldehyde reductase; involved in detoxification of furfural; expression is upregulated in cells treated with the aldehydes furfural and glycolaldehyde, the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001143.9 Reference assembly

      Range
      305114..305884
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001179637.1 → NP_012852.1  TPA: Osi1p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_012852.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6VXL5, P36086
      UniProtKB/TrEMBL
      A0A8H4BY68, B3LR19, B5VM86, N1P2B3
      Conserved Domains (1) summary
      cd05325
      Location:9 → 253
      carb_red_sniffer_like_SDR_c; carbonyl reductase sniffer-like, classical (c) SDRs
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P36086.1

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