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    PUF2 Puf2p [ Saccharomyces cerevisiae S288C ]

    Gene ID: 856155, updated on 17-May-2024

    Summary

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    Gene symbol
    PUF2
    Gene description
    Puf2p
    Primary source
    FungiDB:YPR042C
    Locus tag
    YPR042C
    See related
    SGD:S000006246; AllianceGenome:SGD:S000006246; VEuPathDB:YPR042C
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Saccharomyces cerevisiae S288C (strain: S288C)
    Lineage
    Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
    Summary
    Enables mRNA binding activity. Involved in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
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    Genomic context

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    See PUF2 in Genome Data Viewer
    Location:
    chromosome: XVI
    Exon count:
    1
    Sequence:
    Chromosome: XVI; NC_001148.4 (650435..653662, complement)

    Chromosome XVI - NC_001148.4Genomic Context describing neighboring genes Neighboring gene Tip41p Neighboring gene translation initiation factor eIF5 Neighboring gene ribosomal 60S subunit protein L43A Neighboring gene Thp3p

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_001148.4

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Functional analysis of three adjacent open reading frames from the right arm of yeast chromosome XVI. Waśkiewicz-Staniorowska B, et al. Yeast, 1998 Aug. PMID 9730282
    2. Phosphorylation of mRNA-Binding Proteins Puf1 and Puf2 by TORC2-Activated Protein Kinase Ypk1 Alleviates Their Repressive Effects. Galez HA, et al. Membranes (Basel), 2021 Jun 30. PMID 34209236, Free PMC Article
    3. Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains. Dong S, et al. J Biol Chem, 2011 Jul 29. PMID 21653694, Free PMC Article
    4. Multiple Puf proteins regulate the stability of ribosome biogenesis transcripts. Fischer AD, et al. RNA Biol, 2018. PMID 30251908, Free PMC Article
    5. Extensive association of functionally and cytotopically related mRNAs with Puf family RNA-binding proteins in yeast. Gerber AP, et al. PLoS Biol, 2004 Mar. PMID 15024427, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by SGD

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA 3'-UTR AU-rich region binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables mRNA binding HDA PubMed 
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in negative regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in post-transcriptional regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of biological quality IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in P-body IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    Puf2p
    NP_015367.1
    • PUF family mRNA-binding protein; Pumilio homology domain confers RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins; binding site composed of two UAAU tetranucleotides, separated by a 3-nt linker; PUF2 has a paralog, JSN1, that arose from the whole genome duplication

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_001148.4 Reference assembly

      Range
      650435..653662 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001184139.1 → NP_015367.1  TPA: Puf2p [Saccharomyces cerevisiae S288C]

      See identical proteins and their annotated locations for NP_015367.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      D6W451, Q02573, Q04142, Q12221, Q7LH42, Q7LH98
      UniProtKB/TrEMBL
      A0A8H4F9W0, G2WPL9, N1NWA3
      Conserved Domains (1) summary
      COG5099
      Location:70 → 884
      COG5099; RNA-binding protein of the Puf family, translational repressor [Translation, ribosomal structure and biogenesis]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q12221.1

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